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Article: Secretin induces rapid increases in inositol trisphosphate, cytosolic Ca 2+ and diacylglycerol as well as cyclic AMP in rat pancreatic acini

TitleSecretin induces rapid increases in inositol trisphosphate, cytosolic Ca 2+ and diacylglycerol as well as cyclic AMP in rat pancreatic acini
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1986
PublisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.org
Citation
Biochemical Journal, 1986, v. 239 n. 2, p. 257-261 How to Cite?
AbstractPrevious studies have shown that the dose-response relationship for secretin-stimulated cyclic AMP accumulation is different from that for secretin-stimulated enzyme secretion in the rat exocrine pancreas. Here we show that secretin concentrations of 10 -10 M and higher stimulated a rise in cyclic AMP levels, with maximum effect on cyclic AMP accumulation being achieved already with 10 -8 M-secretin. However, at this concentration of secretin, enzyme secretion rates were approximately half-maximal. Unexpectedly, at concentrations of secretin greater than 10 -8 M there was evidence suggestive of phosphatidylinositol bisphosphate hydrolysis with rapid increase in inositol trisphosphate, cytosolic free calcium and diacylglycerol content of rat pancreatic acini. Furthermore, there was a dose-response relationship among secretin concentration (in the range 10 -8 M-2 x 10 -6 M), increases in inositol trisphosphate and increases in cytosolic free calcium ([Ca 2+](i)). Contrary to what has been previously believed, these results clearly indicate that in rat pancreatic acini secretin not only stimulates cyclic AMP accumulation but also raises inositol trisphosphate, [Ca 2+](i) and diacylglycerol. Thus, two second messenger systems may play a role in the regulation of secretin-induced amylase release.
Persistent Identifierhttp://hdl.handle.net/10722/132683
ISSN
2015 Impact Factor: 3.562
2015 SCImago Journal Rankings: 2.582
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTrimble, ERen_HK
dc.contributor.authorBruzzone, Ren_HK
dc.contributor.authorBiden, TJen_HK
dc.contributor.authorFarese, RVen_HK
dc.date.accessioned2011-03-28T09:28:13Z-
dc.date.available2011-03-28T09:28:13Z-
dc.date.issued1986en_HK
dc.identifier.citationBiochemical Journal, 1986, v. 239 n. 2, p. 257-261en_HK
dc.identifier.issn0264-6021en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132683-
dc.description.abstractPrevious studies have shown that the dose-response relationship for secretin-stimulated cyclic AMP accumulation is different from that for secretin-stimulated enzyme secretion in the rat exocrine pancreas. Here we show that secretin concentrations of 10 -10 M and higher stimulated a rise in cyclic AMP levels, with maximum effect on cyclic AMP accumulation being achieved already with 10 -8 M-secretin. However, at this concentration of secretin, enzyme secretion rates were approximately half-maximal. Unexpectedly, at concentrations of secretin greater than 10 -8 M there was evidence suggestive of phosphatidylinositol bisphosphate hydrolysis with rapid increase in inositol trisphosphate, cytosolic free calcium and diacylglycerol content of rat pancreatic acini. Furthermore, there was a dose-response relationship among secretin concentration (in the range 10 -8 M-2 x 10 -6 M), increases in inositol trisphosphate and increases in cytosolic free calcium ([Ca 2+](i)). Contrary to what has been previously believed, these results clearly indicate that in rat pancreatic acini secretin not only stimulates cyclic AMP accumulation but also raises inositol trisphosphate, [Ca 2+](i) and diacylglycerol. Thus, two second messenger systems may play a role in the regulation of secretin-induced amylase release.en_HK
dc.languageengen_US
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.orgen_HK
dc.relation.ispartofBiochemical Journalen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleSecretin induces rapid increases in inositol trisphosphate, cytosolic Ca 2+ and diacylglycerol as well as cyclic AMP in rat pancreatic acinien_HK
dc.typeArticleen_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3028367en_HK
dc.identifier.scopuseid_2-s2.0-0022541498en_HK
dc.identifier.volume239en_HK
dc.identifier.issue2en_HK
dc.identifier.spage257en_HK
dc.identifier.epage261en_HK
dc.identifier.isiWOS:A1986E476900002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTrimble, ER=7005267920en_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK
dc.identifier.scopusauthoridBiden, TJ=7004993479en_HK
dc.identifier.scopusauthoridFarese, RV=7102200282en_HK

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