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Article: Differences in pancreatic enzyme release from ventral and dorsal areas of the rat pancreas

TitleDifferences in pancreatic enzyme release from ventral and dorsal areas of the rat pancreas
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1986
PublisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpgi.physiology.org/
Citation
American Journal Of Physiology - Gastrointestinal And Liver Physiology, 1986, v. 251 n. 1, p. 14/1 How to Cite?
AbstractThe exocrine secretory function of the ventral and dorsal areas of the rat pancreas was investigated separately. In the isolated perfused rat pancreas, caerulein (10 -12, 10 -11, and 10 -10 M) and carbachol (10 -7 and 10 -6 M) caused a greaterfold increase in pancreatic secretion from the dorsal than the ventral area. Caerulein (10 -9 M) and carbachol (10 -5 M) were supramaximal concentrations with respect to secretion from the dorsal area, but this was not the case in the ventral area. Similar findings were also observed when ventral and dorsal secretions were studied in vivo in anesthetized animals. By contrast, in dispersed acini the sensitivity and responsiveness of tissue from the dorsal and ventral areas were similar to both secretagogues. The possible influence of the endocrine pancreas via the insuloacinar portal system was studied in the perfused pancreas of diabetic rats treated with insulin in vivo. Carbachol (10 -6 M)-stimulated secretion from the ventral area was similar (except for amylase) to that of controls, while a significantly reduced (P < 0.001) output was measured from the dorsal pancreas. These results demonstrate that in the intact pancreas differences of exocrine secretion exist between the ventral and dorsal areas and suggest that insulin may contribute, at least in part, to the expression of such differences.
Persistent Identifierhttp://hdl.handle.net/10722/132682
ISSN
2015 Impact Factor: 3.297
2015 SCImago Journal Rankings: 1.936
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBruzzone, Ren_HK
dc.contributor.authorTrimble, ERen_HK
dc.contributor.authorGjinovci, Aen_HK
dc.contributor.authorRenold, AEen_HK
dc.date.accessioned2011-03-28T09:28:13Z-
dc.date.available2011-03-28T09:28:13Z-
dc.date.issued1986en_HK
dc.identifier.citationAmerican Journal Of Physiology - Gastrointestinal And Liver Physiology, 1986, v. 251 n. 1, p. 14/1en_HK
dc.identifier.issn0193-1857en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132682-
dc.description.abstractThe exocrine secretory function of the ventral and dorsal areas of the rat pancreas was investigated separately. In the isolated perfused rat pancreas, caerulein (10 -12, 10 -11, and 10 -10 M) and carbachol (10 -7 and 10 -6 M) caused a greaterfold increase in pancreatic secretion from the dorsal than the ventral area. Caerulein (10 -9 M) and carbachol (10 -5 M) were supramaximal concentrations with respect to secretion from the dorsal area, but this was not the case in the ventral area. Similar findings were also observed when ventral and dorsal secretions were studied in vivo in anesthetized animals. By contrast, in dispersed acini the sensitivity and responsiveness of tissue from the dorsal and ventral areas were similar to both secretagogues. The possible influence of the endocrine pancreas via the insuloacinar portal system was studied in the perfused pancreas of diabetic rats treated with insulin in vivo. Carbachol (10 -6 M)-stimulated secretion from the ventral area was similar (except for amylase) to that of controls, while a significantly reduced (P < 0.001) output was measured from the dorsal pancreas. These results demonstrate that in the intact pancreas differences of exocrine secretion exist between the ventral and dorsal areas and suggest that insulin may contribute, at least in part, to the expression of such differences.en_HK
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpgi.physiology.org/en_HK
dc.relation.ispartofAmerican Journal of Physiology - Gastrointestinal and Liver Physiologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleDifferences in pancreatic enzyme release from ventral and dorsal areas of the rat pancreasen_HK
dc.typeArticleen_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2425638-
dc.identifier.scopuseid_2-s2.0-0022484105en_HK
dc.identifier.volume251en_HK
dc.identifier.issue1en_HK
dc.identifier.spage14/1en_HK
dc.identifier.epage14/1en_HK
dc.identifier.isiWOS:A1986D295400049-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK
dc.identifier.scopusauthoridTrimble, ER=7005267920en_HK
dc.identifier.scopusauthoridGjinovci, A=6701391657en_HK
dc.identifier.scopusauthoridRenold, AE=7005742513en_HK

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