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Article: H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44
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TitleH5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44
 
AuthorsHo, JW5
Hershkovitz, O3
Peiris, M5 1
Zilka, A3
BarIlan, A3
Nal, B5
Chu, K5
Kudelko, M5
Yiu, WK5
Achdout, H7
Mandelboim, M4
Altmeyer, R5 6
Mandelboim, O7
Bruzzone, R5
Porgador, A3 2
 
Issue Date2008
 
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
 
CitationJournal Of Virology, 2008, v. 82 n. 4, p. 2028-2032 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JVI.02065-07
 
AbstractAntiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by NK cells. In the present study, we investigated the interaction of NKp44 and the hemagglutinin of a primary influenza virus H5N1 isolate. Here we show that recombinant NKp44 recognizes H5-expressing cells and specifically interacts with soluble H5 hemagglutinin. H5-pseudotyped lentiviral particles bind to NK cells expressing NKp44. Following interaction with target cells expressing H5, pseudotyped lentiviral particles, or membrane-associated H5, NK cells show NKp44-mediated induced activity. These findings indicate that NKp44-H5 interactions induce functional NK activation. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
 
ISSN0022-538X
2012 Impact Factor: 5.076
2012 SCImago Journal Rankings: 2.559
 
DOIhttp://dx.doi.org/10.1128/JVI.02065-07
 
PubMed Central IDPMC2258730
 
ISI Accession Number IDWOS:000252909300037
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHo, JW
 
dc.contributor.authorHershkovitz, O
 
dc.contributor.authorPeiris, M
 
dc.contributor.authorZilka, A
 
dc.contributor.authorBarIlan, A
 
dc.contributor.authorNal, B
 
dc.contributor.authorChu, K
 
dc.contributor.authorKudelko, M
 
dc.contributor.authorYiu, WK
 
dc.contributor.authorAchdout, H
 
dc.contributor.authorMandelboim, M
 
dc.contributor.authorAltmeyer, R
 
dc.contributor.authorMandelboim, O
 
dc.contributor.authorBruzzone, R
 
dc.contributor.authorPorgador, A
 
dc.date.accessioned2011-03-28T09:28:12Z
 
dc.date.available2011-03-28T09:28:12Z
 
dc.date.issued2008
 
dc.description.abstractAntiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by NK cells. In the present study, we investigated the interaction of NKp44 and the hemagglutinin of a primary influenza virus H5N1 isolate. Here we show that recombinant NKp44 recognizes H5-expressing cells and specifically interacts with soluble H5 hemagglutinin. H5-pseudotyped lentiviral particles bind to NK cells expressing NKp44. Following interaction with target cells expressing H5, pseudotyped lentiviral particles, or membrane-associated H5, NK cells show NKp44-mediated induced activity. These findings indicate that NKp44-H5 interactions induce functional NK activation. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationJournal Of Virology, 2008, v. 82 n. 4, p. 2028-2032 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JVI.02065-07
 
dc.identifier.citeulike2705521
 
dc.identifier.doihttp://dx.doi.org/10.1128/JVI.02065-07
 
dc.identifier.epage2032
 
dc.identifier.isiWOS:000252909300037
 
dc.identifier.issn0022-538X
2012 Impact Factor: 5.076
2012 SCImago Journal Rankings: 2.559
 
dc.identifier.issue4
 
dc.identifier.pmcidPMC2258730
 
dc.identifier.pmid18077718
 
dc.identifier.scopuseid_2-s2.0-38849199239
 
dc.identifier.spage2028
 
dc.identifier.urihttp://hdl.handle.net/10722/132681
 
dc.identifier.volume82
 
dc.languageeng
 
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Virology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.
 
dc.rightsCopyright © American Society for Microbiology, [Journal of Virology, 2008, v. 82 n. 4, p. 2028-2032]
 
dc.subject.meshHemagglutinin Glycoproteins, Influenza Virus - genetics - metabolism
 
dc.subject.meshInfluenza A Virus, H5N1 Subtype - immunology
 
dc.subject.meshKiller Cells, Natural - immunology - virology
 
dc.subject.meshReceptors, Immunologic - genetics - metabolism
 
dc.subject.meshRecombinant Proteins - genetics - metabolism
 
dc.titleH5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44
 
dc.typeArticle
 
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<description.abstract>Antiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by NK cells. In the present study, we investigated the interaction of NKp44 and the hemagglutinin of a primary influenza virus H5N1 isolate. Here we show that recombinant NKp44 recognizes H5-expressing cells and specifically interacts with soluble H5 hemagglutinin. H5-pseudotyped lentiviral particles bind to NK cells expressing NKp44. Following interaction with target cells expressing H5, pseudotyped lentiviral particles, or membrane-associated H5, NK cells show NKp44-mediated induced activity. These findings indicate that NKp44-H5 interactions induce functional NK activation. Copyright &#169; 2008, American Society for Microbiology. All Rights Reserved.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Ben-Gurion University of the Negev
  3. Ben-Gurion University of the Negev Faculty of Health Sciences
  4. Israel Ministry of Health
  5. HKU-Pasteur Research Centre
  6. CombinatoRx Singapore Ltd.
  7. Hebrew University-Hadassah Medical School