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Article: H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44

TitleH5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44
Authors
Ho, JWHershkovitz, OPeiris, MZilka, ABarIlan, ANal, BChu, KKudelko, MYiu, WKAchdout, HMandelboim, MAltmeyer, RMandelboim, OBruzzone, RPorgador, A
Issue Date2008
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2008, v. 82 n. 4, p. 2028-2032 How to Cite?
DOI: http://dx.doi.org/10.1128/JVI.02065-07
AbstractAntiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by NK cells. In the present study, we investigated the interaction of NKp44 and the hemagglutinin of a primary influenza virus H5N1 isolate. Here we show that recombinant NKp44 recognizes H5-expressing cells and specifically interacts with soluble H5 hemagglutinin. H5-pseudotyped lentiviral particles bind to NK cells expressing NKp44. Following interaction with target cells expressing H5, pseudotyped lentiviral particles, or membrane-associated H5, NK cells show NKp44-mediated induced activity. These findings indicate that NKp44-H5 interactions induce functional NK activation. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/132681
ISSN
0022-538X
2023 Impact Factor: 4.0
2023 SCImago Journal Rankings: 1.378
PubMed Central ID
PMC2258730
ISI Accession Number ID
WOS:000252909300037
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorHo, JWen_HK
dc.contributor.authorHershkovitz, Oen_HK
dc.contributor.authorPeiris, Men_HK
dc.contributor.authorZilka, Aen_HK
dc.contributor.authorBarIlan, Aen_HK
dc.contributor.authorNal, Ben_HK
dc.contributor.authorChu, Ken_HK
dc.contributor.authorKudelko, Men_HK
dc.contributor.authorYiu, WKen_HK
dc.contributor.authorAchdout, Hen_HK
dc.contributor.authorMandelboim, Men_HK
dc.contributor.authorAltmeyer, Ren_HK
dc.contributor.authorMandelboim, Oen_HK
dc.contributor.authorBruzzone, Ren_HK
dc.contributor.authorPorgador, Aen_HK
dc.date.accessioned2011-03-28T09:28:12Z-
dc.date.available2011-03-28T09:28:12Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Virology, 2008, v. 82 n. 4, p. 2028-2032en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/132681-
dc.description.abstractAntiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by NK cells. In the present study, we investigated the interaction of NKp44 and the hemagglutinin of a primary influenza virus H5N1 isolate. Here we show that recombinant NKp44 recognizes H5-expressing cells and specifically interacts with soluble H5 hemagglutinin. H5-pseudotyped lentiviral particles bind to NK cells expressing NKp44. Following interaction with target cells expressing H5, pseudotyped lentiviral particles, or membrane-associated H5, NK cells show NKp44-mediated induced activity. These findings indicate that NKp44-H5 interactions induce functional NK activation. Copyright © 2008, American Society for Microbiology. All Rights Reserved.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.-
dc.rightsCopyright © American Society for Microbiology, [Journal of Virology, 2008, v. 82 n. 4, p. 2028-2032]-
dc.subject.meshHemagglutinin Glycoproteins, Influenza Virus - genetics - metabolism-
dc.subject.meshInfluenza A Virus, H5N1 Subtype - immunology-
dc.subject.meshKiller Cells, Natural - immunology - virology-
dc.subject.meshReceptors, Immunologic - genetics - metabolism-
dc.subject.meshRecombinant Proteins - genetics - metabolism-
dc.titleH5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44en_HK
dc.typeArticleen_HK
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_HK
dc.identifier.emailNal, B: bnal@hkucc.hku.hken_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, M=rp00410en_HK
dc.identifier.authorityNal, B=rp00541en_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1128/JVI.02065-07en_HK
dc.identifier.pmid18077718-
dc.identifier.pmcidPMC2258730-
dc.identifier.scopuseid_2-s2.0-38849199239en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38849199239&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume82en_HK
dc.identifier.issue4en_HK
dc.identifier.spage2028en_HK
dc.identifier.epage2032en_HK
dc.identifier.isiWOS:000252909300037-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, JW=36952424400en_HK
dc.identifier.scopusauthoridHershkovitz, O=9043242400en_HK
dc.identifier.scopusauthoridPeiris, M=7005486823en_HK
dc.identifier.scopusauthoridZilka, A=7801341196en_HK
dc.identifier.scopusauthoridBarIlan, A=7004756567en_HK
dc.identifier.scopusauthoridNal, B=6506672380en_HK
dc.identifier.scopusauthoridChu, K=8415242400en_HK
dc.identifier.scopusauthoridKudelko, M=35083703200en_HK
dc.identifier.scopusauthoridYiu, WK=35084595500en_HK
dc.identifier.scopusauthoridAchdout, H=6602767789en_HK
dc.identifier.scopusauthoridMandelboim, M=7801547586en_HK
dc.identifier.scopusauthoridAltmeyer, R=7003677186en_HK
dc.identifier.scopusauthoridMandelboim, O=7003391581en_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK
dc.identifier.scopusauthoridPorgador, A=7003872024en_HK
dc.identifier.citeulike2705521-
dc.identifier.issnl0022-538X-

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