Article: H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44

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Publisher Website: 10.1128/JVI.02065-07
Scopus: eid_2-s2.0-38849199239
PMID: 18077718

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Title	H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44
Authors	Ho, JW6 Hershkovitz, O3 Peiris, M1 6 Zilka, A3 BarIlan, A3 Nal, B6 Chu, K6 Kudelko, M6 Yiu, WK6 Achdout, H7 Mandelboim, M4 Altmeyer, R5 6 Mandelboim, O7 Bruzzone, R6 Porgador, A2 3
Issue Date	2008
Publisher	American Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation	Journal Of Virology, 2008, v. 82 n. 4, p. 2028-2032 [How to Cite?] DOI: http://dx.doi.org/10.1128/JVI.02065-07
Abstract	Antiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by NK cells. In the present study, we investigated the interaction of NKp44 and the hemagglutinin of a primary influenza virus H5N1 isolate. Here we show that recombinant NKp44 recognizes H5-expressing cells and specifically interacts with soluble H5 hemagglutinin. H5-pseudotyped lentiviral particles bind to NK cells expressing NKp44. Following interaction with target cells expressing H5, pseudotyped lentiviral particles, or membrane-associated H5, NK cells show NKp44-mediated induced activity. These findings indicate that NKp44-H5 interactions induce functional NK activation. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
ISSN	0022-538X 2011 Impact Factor: 5.402 2011 SCImago Journal Rankings: 0.745
DOI	http://dx.doi.org/10.1128/JVI.02065-07
ISI Accession Number ID	WOS:000252909300037
PubMed Central ID	PMC2258730
References	References in Scopus

DC Field	Value
dc.contributor.author	Ho, JW
dc.contributor.author	Hershkovitz, O
dc.contributor.author	Peiris, M
dc.contributor.author	Zilka, A
dc.contributor.author	BarIlan, A
dc.contributor.author	Nal, B
dc.contributor.author	Chu, K
dc.contributor.author	Kudelko, M
dc.contributor.author	Yiu, WK
dc.contributor.author	Achdout, H
dc.contributor.author	Mandelboim, M
dc.contributor.author	Altmeyer, R
dc.contributor.author	Mandelboim, O
dc.contributor.author	Bruzzone, R
dc.contributor.author	Porgador, A
dc.date.accessioned	2011-03-28T09:28:12Z
dc.date.available	2011-03-28T09:28:12Z
dc.date.issued	2008
dc.description.abstract	Antiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by NK cells. In the present study, we investigated the interaction of NKp44 and the hemagglutinin of a primary influenza virus H5N1 isolate. Here we show that recombinant NKp44 recognizes H5-expressing cells and specifically interacts with soluble H5 hemagglutinin. H5-pseudotyped lentiviral particles bind to NK cells expressing NKp44. Following interaction with target cells expressing H5, pseudotyped lentiviral particles, or membrane-associated H5, NK cells show NKp44-mediated induced activity. These findings indicate that NKp44-H5 interactions induce functional NK activation. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
dc.description.nature	link_to_OA_fulltext
dc.identifier.citation	Journal Of Virology, 2008, v. 82 n. 4, p. 2028-2032 [How to Cite?] DOI: http://dx.doi.org/10.1128/JVI.02065-07
dc.identifier.citeulike	2705521
dc.identifier.doi	http://dx.doi.org/10.1128/JVI.02065-07
dc.identifier.epage	2032
dc.identifier.isi	WOS:000252909300037
dc.identifier.issn	0022-538X 2011 Impact Factor: 5.402 2011 SCImago Journal Rankings: 0.745
dc.identifier.issue	4
dc.identifier.pmcid	PMC2258730
dc.identifier.pmid	18077718
dc.identifier.scopus	eid_2-s2.0-38849199239
dc.identifier.spage	2028
dc.identifier.uri	http://hdl.handle.net/10722/132681
dc.identifier.volume	82
dc.language	eng
dc.publisher	American Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
dc.publisher.place	United States
dc.relation.ispartof	Journal of Virology
dc.relation.references	References in Scopus
dc.rights	Journal of Virology. Copyright © American Society for Microbiology.
dc.rights	Copyright © American Society for Microbiology, [Journal of Virology, 2008, v. 82 n. 4, p. 2028-2032]
dc.subject.mesh	Hemagglutinin Glycoproteins, Influenza Virus - genetics - metabolism
dc.subject.mesh	Influenza A Virus, H5N1 Subtype - immunology
dc.subject.mesh	Killer Cells, Natural - immunology - virology
dc.subject.mesh	Receptors, Immunologic - genetics - metabolism
dc.subject.mesh	Recombinant Proteins - genetics - metabolism
dc.title	H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44
dc.type	Article

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Author Affiliations

The University of Hong Kong
Ben-Gurion University of the Negev
Ben-Gurion University of the Negev Faculty of Health Sciences
Israel Ministry of Health
CombinatoRx Singapore Ltd.
HKU-Pasteur Research Centre
Hebrew University-Hadassah Medical School