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Article: Rapid increases in inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate and cytosolic free Ca 2+ in agonist-stimulated pancreatic acini of the rat. Effect of carbachol, caerulein and secretin

TitleRapid increases in inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate and cytosolic free Ca 2+ in agonist-stimulated pancreatic acini of the rat. Effect of carbachol, caerulein and secretin
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1987
PublisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.org
Citation
Biochemical Journal, 1987, v. 242 n. 1, p. 289-292 How to Cite?
AbstractWe compared the time course of increases in isomers of inositol trisphosphate [Ins(1,4,5)P 3] and Ins(1,3,4)P 3] and the tetrakisphosphate [Ins(1,3,4,5)P 4] with changes in cytosolic free Ca 2+ ([Ca 2+](i)) in dispersed pancreatic acini of the rat. There were rapid (5s) increases in Ins(1,4,5)P 3 and Ins(1,3,4,5)P 4 in response to carbachol, caerulein and secretin, whereas Ins(1,3,4)P 3 increased more slowly. All three secretagogues induced increases in [Ca 2+](i), which reached a peak at 15-20 s. Our results indicate that the very rapid formation of Ins(1,4,5)P 3 is compatible with its second-messenger role in the initial elevation of [Ca 2+](i).
Persistent Identifierhttp://hdl.handle.net/10722/132676
ISSN
2015 Impact Factor: 3.562
2015 SCImago Journal Rankings: 2.582
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTrimble, ERen_HK
dc.contributor.authorBruzzone, Ren_HK
dc.contributor.authorMeehan, CJen_HK
dc.contributor.authorBiden, TJen_HK
dc.date.accessioned2011-03-28T09:28:09Z-
dc.date.available2011-03-28T09:28:09Z-
dc.date.issued1987en_HK
dc.identifier.citationBiochemical Journal, 1987, v. 242 n. 1, p. 289-292en_HK
dc.identifier.issn0264-6021en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132676-
dc.description.abstractWe compared the time course of increases in isomers of inositol trisphosphate [Ins(1,4,5)P 3] and Ins(1,3,4)P 3] and the tetrakisphosphate [Ins(1,3,4,5)P 4] with changes in cytosolic free Ca 2+ ([Ca 2+](i)) in dispersed pancreatic acini of the rat. There were rapid (5s) increases in Ins(1,4,5)P 3 and Ins(1,3,4,5)P 4 in response to carbachol, caerulein and secretin, whereas Ins(1,3,4)P 3 increased more slowly. All three secretagogues induced increases in [Ca 2+](i), which reached a peak at 15-20 s. Our results indicate that the very rapid formation of Ins(1,4,5)P 3 is compatible with its second-messenger role in the initial elevation of [Ca 2+](i).en_HK
dc.languageengen_US
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.orgen_HK
dc.relation.ispartofBiochemical Journalen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleRapid increases in inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate and cytosolic free Ca 2+ in agonist-stimulated pancreatic acini of the rat. Effect of carbachol, caerulein and secretinen_HK
dc.typeArticleen_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3496081-
dc.identifier.scopuseid_2-s2.0-0023118751en_HK
dc.identifier.volume242en_HK
dc.identifier.issue1en_HK
dc.identifier.spage289en_HK
dc.identifier.epage292en_HK
dc.identifier.isiWOS:A1987G184000041-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTrimble, ER=7005267920en_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK
dc.identifier.scopusauthoridMeehan, CJ=36913910800en_HK
dc.identifier.scopusauthoridBiden, TJ=7004993479en_HK

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