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Article: Direct stimulation of enzyme secretion from rat exocrine pancreas by neurotensin and its naturally occurring fragments

TitleDirect stimulation of enzyme secretion from rat exocrine pancreas by neurotensin and its naturally occurring fragments
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1987
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Gastroenterology, 1987, v. 92 n. 3, p. 699-703 How to Cite?
AbstractNeurotensin stimulates amylase release from dispersed pancreatic acini at concentrations as low as 10 -15 M. The naturally occurring fragments of neurotensin (NT), NT 1-8 and NT 1-11, also stimulate amylase secretion at concentrations that occur in peripheral plasma (10 -11 M). The analogue D-Phe 11 neurotensin was as potent as neurotensin itself with respect to stimulation of amylase secretion. Basal plasma neurotensin levels were ~10 pmol/L, a concentration that stimulates the exocrine pancrease in vitro. Increases in plasma neurotensin levels induced by infusion of neurotensin caused greater increases in secretion of pancreatic amylase than did similar changes of neurotensin concentration in vitro. These results suggest that in addition to its direct action, other factors are involved in modulation of the effects of neurotensin on pancreatic exocrine function in vivo.
Persistent Identifierhttp://hdl.handle.net/10722/132673
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTrimble, ERen_HK
dc.contributor.authorShaw, Cen_HK
dc.contributor.authorBruzzone, Ren_HK
dc.date.accessioned2011-03-28T09:28:07Z-
dc.date.available2011-03-28T09:28:07Z-
dc.date.issued1987en_HK
dc.identifier.citationGastroenterology, 1987, v. 92 n. 3, p. 699-703en_HK
dc.identifier.issn0016-5085en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132673-
dc.description.abstractNeurotensin stimulates amylase release from dispersed pancreatic acini at concentrations as low as 10 -15 M. The naturally occurring fragments of neurotensin (NT), NT 1-8 and NT 1-11, also stimulate amylase secretion at concentrations that occur in peripheral plasma (10 -11 M). The analogue D-Phe 11 neurotensin was as potent as neurotensin itself with respect to stimulation of amylase secretion. Basal plasma neurotensin levels were ~10 pmol/L, a concentration that stimulates the exocrine pancrease in vitro. Increases in plasma neurotensin levels induced by infusion of neurotensin caused greater increases in secretion of pancreatic amylase than did similar changes of neurotensin concentration in vitro. These results suggest that in addition to its direct action, other factors are involved in modulation of the effects of neurotensin on pancreatic exocrine function in vivo.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_HK
dc.relation.ispartofGastroenterologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleDirect stimulation of enzyme secretion from rat exocrine pancreas by neurotensin and its naturally occurring fragmentsen_HK
dc.typeArticleen_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2434384-
dc.identifier.scopuseid_2-s2.0-0023108871en_HK
dc.identifier.volume92en_HK
dc.identifier.issue3en_HK
dc.identifier.spage699en_HK
dc.identifier.epage703en_HK
dc.identifier.isiWOS:A1987G661100019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTrimble, ER=7005267920en_HK
dc.identifier.scopusauthoridShaw, C=35370980900en_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK

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