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Article: A case of mixed adult Wilms' tumour and angiosarcoma responsive to carboplatin, etoposide and vincristine (CEO)

TitleA case of mixed adult Wilms' tumour and angiosarcoma responsive to carboplatin, etoposide and vincristine (CEO)
Authors
KeywordsAdult Wilm's tumour
Angiosarcoma
Drug therapy
Issue Date2008
PublisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/oncology/journal/280
Citation
Cancer Chemotherapy And Pharmacology, 2008, v. 61 n. 4, p. 717-720 How to Cite?
AbstractHere we report an unusual case of mixed Wilms' tumour and angiosarcoma in a 38-year-old female patient who presented with haematuria and right lower back pain. A computed tomographic (CT) scan confirmed a massive renal tumour associated with extensive retroperitoneal lymph node involvement, bony metastases and a right hip fracture. She was initially managed with palliative nephrectomy, which was followed by rapid postoperative deterioration. Histopathology revealed differentiated adult Wilms' tumour with renal angiosarcoma, whereas the pathology of the para-aortic lymph node and bone metastasis revealed angiosarcoma only. In view of her cachexia and cytopaenia, emergency chemotherapy was initiated using a modified regimen of carboplatin, etoposide and vincristine (CEO) in preference to the more traditional but less well-tolerated VAC (vincristine, actinomycin D, cyclophosphamide). Four cycles of this protocol yielded a dramatic response on re-staging CT scan. This case suggests that highly angiogenic tumours such as angiosarcoma may be effectively palliated using agents usually reserved for refractory Wilms' tumour, and supports the view that adult Wilms' tumour is more sensitive to such agents. © 2007 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/132659
ISSN
2014 Impact Factor: 2.769
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYau, Ten_HK
dc.contributor.authorLeong, CHen_HK
dc.contributor.authorChan, WKen_HK
dc.contributor.authorChan, JKen_HK
dc.contributor.authorLiang, RHSen_HK
dc.contributor.authorEpstein, RJen_HK
dc.date.accessioned2011-03-28T09:27:28Z-
dc.date.available2011-03-28T09:27:28Z-
dc.date.issued2008en_HK
dc.identifier.citationCancer Chemotherapy And Pharmacology, 2008, v. 61 n. 4, p. 717-720en_HK
dc.identifier.issn0344-5704en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132659-
dc.description.abstractHere we report an unusual case of mixed Wilms' tumour and angiosarcoma in a 38-year-old female patient who presented with haematuria and right lower back pain. A computed tomographic (CT) scan confirmed a massive renal tumour associated with extensive retroperitoneal lymph node involvement, bony metastases and a right hip fracture. She was initially managed with palliative nephrectomy, which was followed by rapid postoperative deterioration. Histopathology revealed differentiated adult Wilms' tumour with renal angiosarcoma, whereas the pathology of the para-aortic lymph node and bone metastasis revealed angiosarcoma only. In view of her cachexia and cytopaenia, emergency chemotherapy was initiated using a modified regimen of carboplatin, etoposide and vincristine (CEO) in preference to the more traditional but less well-tolerated VAC (vincristine, actinomycin D, cyclophosphamide). Four cycles of this protocol yielded a dramatic response on re-staging CT scan. This case suggests that highly angiogenic tumours such as angiosarcoma may be effectively palliated using agents usually reserved for refractory Wilms' tumour, and supports the view that adult Wilms' tumour is more sensitive to such agents. © 2007 Springer-Verlag.en_HK
dc.languageengen_US
dc.publisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/oncology/journal/280en_HK
dc.relation.ispartofCancer Chemotherapy and Pharmacologyen_HK
dc.subjectAdult Wilm's tumouren_HK
dc.subjectAngiosarcomaen_HK
dc.subjectDrug therapyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAntineoplastic Agents - administration & dosageen_HK
dc.subject.meshAntineoplastic Agents, Phytogenic - administration & dosageen_HK
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - administration & dosage - adverse effects - therapeutic useen_HK
dc.subject.meshCarboplatin - administration & dosageen_HK
dc.subject.meshCombined Modality Therapyen_HK
dc.subject.meshEtoposide - administration & dosageen_HK
dc.subject.meshFatal Outcomeen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHemangiosarcoma - drug therapy - pathology - surgeryen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKidney Neoplasms - drug therapy - pathology - surgeryen_HK
dc.subject.meshMagnetic Resonance Imagingen_HK
dc.subject.meshNeoplasm Metastasisen_HK
dc.subject.meshNeoplasm Recurrence, Localen_HK
dc.subject.meshPlatelet Counten_HK
dc.subject.meshTomography, X-Ray Computeden_HK
dc.subject.meshVincristine - administration & dosageen_HK
dc.subject.meshWilms Tumor - drug therapy - pathology - surgeryen_HK
dc.titleA case of mixed adult Wilms' tumour and angiosarcoma responsive to carboplatin, etoposide and vincristine (CEO)en_HK
dc.typeArticleen_HK
dc.identifier.emailYau, T: tyaucc@hku.hken_HK
dc.identifier.emailLiang, RHS: rliang@hku.hken_HK
dc.identifier.emailEpstein, RJ: repstein@hku.hken_HK
dc.identifier.authorityYau, T=rp01466en_HK
dc.identifier.authorityLiang, RHS=rp00345en_HK
dc.identifier.authorityEpstein, RJ=rp00501en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00280-007-0529-1en_HK
dc.identifier.pmid17571263en_HK
dc.identifier.scopuseid_2-s2.0-38049008451en_HK
dc.identifier.hkuros131216-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38049008451&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume61en_HK
dc.identifier.issue4en_HK
dc.identifier.spage717en_HK
dc.identifier.epage720en_HK
dc.identifier.isiWOS:000252222900022-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridYau, T=23391533100en_HK
dc.identifier.scopusauthoridLeong, CH=23390007300en_HK
dc.identifier.scopusauthoridChan, WK=8059126200en_HK
dc.identifier.scopusauthoridChan, JK=7403287069en_HK
dc.identifier.scopusauthoridLiang, RHS=26643224900en_HK
dc.identifier.scopusauthoridEpstein, RJ=34975074500en_HK

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