Article: A case of mixed adult Wilms' tumour and angiosarcoma responsive to carboplatin, etoposide and vincristine (CEO)

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TitleA case of mixed adult Wilms' tumour and angiosarcoma responsive to carboplatin, etoposide and vincristine (CEO)
AuthorsYau, T1
Leong, CH
Chan, WK3
Chan, JK2
Liang, RHS1
Epstein, RJ1
KeywordsAdult Wilm's tumour
Angiosarcoma
Drug therapy
Issue Date2008
PublisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/oncology/journal/280
CitationCancer Chemotherapy And Pharmacology, 2008, v. 61 n. 4, p. 717-720 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00280-007-0529-1
AbstractHere we report an unusual case of mixed Wilms' tumour and angiosarcoma in a 38-year-old female patient who presented with haematuria and right lower back pain. A computed tomographic (CT) scan confirmed a massive renal tumour associated with extensive retroperitoneal lymph node involvement, bony metastases and a right hip fracture. She was initially managed with palliative nephrectomy, which was followed by rapid postoperative deterioration. Histopathology revealed differentiated adult Wilms' tumour with renal angiosarcoma, whereas the pathology of the para-aortic lymph node and bone metastasis revealed angiosarcoma only. In view of her cachexia and cytopaenia, emergency chemotherapy was initiated using a modified regimen of carboplatin, etoposide and vincristine (CEO) in preference to the more traditional but less well-tolerated VAC (vincristine, actinomycin D, cyclophosphamide). Four cycles of this protocol yielded a dramatic response on re-staging CT scan. This case suggests that highly angiogenic tumours such as angiosarcoma may be effectively palliated using agents usually reserved for refractory Wilms' tumour, and supports the view that adult Wilms' tumour is more sensitive to such agents. © 2007 Springer-Verlag.
ISSN0344-5704
2011 Impact Factor: 2.833
2011 SCImago Journal Rankings: 0.246
DOIhttp://dx.doi.org/10.1007/s00280-007-0529-1
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorYau, T
dc.contributor.authorLeong, CH
dc.contributor.authorChan, WK
dc.contributor.authorChan, JK
dc.contributor.authorLiang, RHS
dc.contributor.authorEpstein, RJ
dc.date.accessioned2011-03-28T09:27:28Z
dc.date.available2011-03-28T09:27:28Z
dc.date.issued2008
dc.description.abstractHere we report an unusual case of mixed Wilms' tumour and angiosarcoma in a 38-year-old female patient who presented with haematuria and right lower back pain. A computed tomographic (CT) scan confirmed a massive renal tumour associated with extensive retroperitoneal lymph node involvement, bony metastases and a right hip fracture. She was initially managed with palliative nephrectomy, which was followed by rapid postoperative deterioration. Histopathology revealed differentiated adult Wilms' tumour with renal angiosarcoma, whereas the pathology of the para-aortic lymph node and bone metastasis revealed angiosarcoma only. In view of her cachexia and cytopaenia, emergency chemotherapy was initiated using a modified regimen of carboplatin, etoposide and vincristine (CEO) in preference to the more traditional but less well-tolerated VAC (vincristine, actinomycin D, cyclophosphamide). Four cycles of this protocol yielded a dramatic response on re-staging CT scan. This case suggests that highly angiogenic tumours such as angiosarcoma may be effectively palliated using agents usually reserved for refractory Wilms' tumour, and supports the view that adult Wilms' tumour is more sensitive to such agents. © 2007 Springer-Verlag.
dc.description.naturelink_to_subscribed_fulltext
dc.identifier.citationCancer Chemotherapy And Pharmacology, 2008, v. 61 n. 4, p. 717-720 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00280-007-0529-1
dc.identifier.doihttp://dx.doi.org/10.1007/s00280-007-0529-1
dc.identifier.epage720
dc.identifier.hkuros131216
dc.identifier.isiWOS:000252222900022
dc.identifier.issn0344-5704
2011 Impact Factor: 2.833
2011 SCImago Journal Rankings: 0.246
dc.identifier.issue4
dc.identifier.pmid17571263
dc.identifier.scopuseid_2-s2.0-38049008451
dc.identifier.spage717
dc.identifier.urihttp://hdl.handle.net/10722/132659
dc.identifier.volume61
dc.languageeng
dc.publisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/oncology/journal/280
dc.publisher.placeGermany
dc.relation.ispartofCancer Chemotherapy and Pharmacology
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAntineoplastic Agents - administration & dosage
dc.subject.meshAntineoplastic Agents, Phytogenic - administration & dosage
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - administration & dosage - adverse effects - therapeutic use
dc.subject.meshCarboplatin - administration & dosage
dc.subject.meshCombined Modality Therapy
dc.subject.meshEtoposide - administration & dosage
dc.subject.meshFatal Outcome
dc.subject.meshFemale
dc.subject.meshHemangiosarcoma - drug therapy - pathology - surgery
dc.subject.meshHumans
dc.subject.meshKidney Neoplasms - drug therapy - pathology - surgery
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshNeoplasm Metastasis
dc.subject.meshNeoplasm Recurrence, Local
dc.subject.meshPlatelet Count
dc.subject.meshTomography, X-Ray Computed
dc.subject.meshVincristine - administration & dosage
dc.subject.meshWilms Tumor - drug therapy - pathology - surgery
dc.subjectAdult Wilm's tumour
dc.subjectAngiosarcoma
dc.subjectDrug therapy
dc.titleA case of mixed adult Wilms' tumour and angiosarcoma responsive to carboplatin, etoposide and vincristine (CEO)
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Queen Elizabeth Hospital Hong Kong
  3. Hong Kong Sanatorium and Hospital