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Article: Longitudinal assessment of quality of life in rectal cancer patients with or without stomas following primary resection

TitleLongitudinal assessment of quality of life in rectal cancer patients with or without stomas following primary resection
Authors
KeywordsQuality of life
Rectal cancer
Social functioning
Stoma
Issue Date2009
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.dcrjournal.com/
Citation
Diseases Of The Colon And Rectum, 2009, v. 52 n. 4, p. 669-677 How to Cite?
AbstractPURPOSE: The purpose of this study was to assess the longitudinal impact of stoma formation on the health-related quality of life of rectal cancer patients treated with adjuvant chemotherapy. METHODS: Health-related quality of life data was prospectively collected in a randomized trial designed to compare 24 weeks of bolus 5-fluorouracil/leucovorin with 12 weeks of continuous 5-fluorouracil in patients with resected Dukes B and C colorectal cancer. Health-related quality of life data was collected at baseline, during adjuvant treatment, and at one and three years after completion of chemotherapy. RESULTS: Between 1993 and 2003, 186 rectal cancer patients were enrolled. One hundred thirty-nine patients had anterior resection, of whom 46 had a temporary defunctioning colostomy. Forty-seven patients had abdominoperineal resection with formation of a permanent colostomy. There was no significant difference in global health-related quality of life between patients with and patients without a stoma at any time point. However, during adjuvant treatment, role (P = 0.04) and social (P = 0.005) functioning were significantly worse in stoma patients than in nonstoma patients. Moreover, the impairment in social functioning persisted at one (P = 0.03) and three years (P = 0.04) after adjuvant chemotherapy. CONCLUSION: Our results demonstrate important adverse effects of either temporary or permanent stoma formation on subsequent health-related quality of life in patients with rectal cancer. © The ASCRS 2009.
Persistent Identifierhttp://hdl.handle.net/10722/132646
ISSN
2015 Impact Factor: 3.739
2015 SCImago Journal Rankings: 2.077
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYau, Ten_HK
dc.contributor.authorWatkins, Den_HK
dc.contributor.authorCunningham, Den_HK
dc.contributor.authorBarbachano, Yen_HK
dc.contributor.authorChau, Ien_HK
dc.contributor.authorChong, Gen_HK
dc.date.accessioned2011-03-28T09:27:22Z-
dc.date.available2011-03-28T09:27:22Z-
dc.date.issued2009en_HK
dc.identifier.citationDiseases Of The Colon And Rectum, 2009, v. 52 n. 4, p. 669-677en_HK
dc.identifier.issn0012-3706en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132646-
dc.description.abstractPURPOSE: The purpose of this study was to assess the longitudinal impact of stoma formation on the health-related quality of life of rectal cancer patients treated with adjuvant chemotherapy. METHODS: Health-related quality of life data was prospectively collected in a randomized trial designed to compare 24 weeks of bolus 5-fluorouracil/leucovorin with 12 weeks of continuous 5-fluorouracil in patients with resected Dukes B and C colorectal cancer. Health-related quality of life data was collected at baseline, during adjuvant treatment, and at one and three years after completion of chemotherapy. RESULTS: Between 1993 and 2003, 186 rectal cancer patients were enrolled. One hundred thirty-nine patients had anterior resection, of whom 46 had a temporary defunctioning colostomy. Forty-seven patients had abdominoperineal resection with formation of a permanent colostomy. There was no significant difference in global health-related quality of life between patients with and patients without a stoma at any time point. However, during adjuvant treatment, role (P = 0.04) and social (P = 0.005) functioning were significantly worse in stoma patients than in nonstoma patients. Moreover, the impairment in social functioning persisted at one (P = 0.03) and three years (P = 0.04) after adjuvant chemotherapy. CONCLUSION: Our results demonstrate important adverse effects of either temporary or permanent stoma formation on subsequent health-related quality of life in patients with rectal cancer. © The ASCRS 2009.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.dcrjournal.com/en_HK
dc.relation.ispartofDiseases of the Colon and Rectumen_HK
dc.subjectQuality of lifeen_HK
dc.subjectRectal canceren_HK
dc.subjectSocial functioningen_HK
dc.subjectStomaen_HK
dc.titleLongitudinal assessment of quality of life in rectal cancer patients with or without stomas following primary resectionen_HK
dc.typeArticleen_HK
dc.identifier.emailYau, T: tyaucc@hku.hken_HK
dc.identifier.authorityYau, T=rp01466en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/DCR.0b013e31819eb970en_HK
dc.identifier.pmid19404073-
dc.identifier.scopuseid_2-s2.0-66849138074en_HK
dc.identifier.hkuros216952-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-66849138074&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue4en_HK
dc.identifier.spage669en_HK
dc.identifier.epage677en_HK
dc.identifier.eissn1530-0358-
dc.identifier.isiWOS:000273643900022-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYau, T=23391533100en_HK
dc.identifier.scopusauthoridWatkins, D=16493778600en_HK
dc.identifier.scopusauthoridCunningham, D=36071300500en_HK
dc.identifier.scopusauthoridBarbachano, Y=23479576900en_HK
dc.identifier.scopusauthoridChau, I=14526721100en_HK
dc.identifier.scopusauthoridChong, G=8596074200en_HK

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