File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Presence of an in situ component is associated with reduced biological aggressiveness of size-matched invasive breast cancer

TitlePresence of an in situ component is associated with reduced biological aggressiveness of size-matched invasive breast cancer
Authors
KeywordsBreast neoplasms
Carcinogenesis
Intraductal
Ki-67
Pre-invasive
Tumour progression
Issue Date2010
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
Citation
British Journal Of Cancer, 2010, v. 102 n. 9, p. 1391-1396 How to Cite?
AbstractBackground:The metastatic propensity of invasive ductal carcinoma (IDC) of the breast correlates with axillary node involvement and with expression of the proliferation antigen Ki-67, whereas ductal carcinoma in situ (DCIS) is non-metastasising. To clarify whether concomitant DCIS affects IDC prognosis, we compared Ki-67 expression and node status of size-matched IDC subgroups either with DCIS (IDC-DCIS) or without DCIS (pure IDC).Methods:We analysed data from 1355 breast cancer patients. End points were defined by the association of IDC (with or without DCIS) with grade, nodal status, Ki-67, and ER/HER2.Results: Size-matched IDC-DCIS was more likely than pure IDC to be screen detected (P0.03), to occur in pre-menopausal women (P0.002), and to be either ER-positive (P0.002) or HER2-positive (P0.0005), but less likely to be treated with breast-conserving surgery (P0.004). Grade and Ki-67 were lower in IDC-DCIS than in pure IDC (P0.02), and declined as the DCIS enlarged (P0.01). Node involvement and lymphovascular invasion in IDC-DCIS increased with the size ratio of IDC to DCIS (P0.01). A 60-month cancer-specific survival favoured IDC-DCIS over size-matched pure IDC (97.4 vs 96.0%).Conclusion:IDC co-existing with DCIS is characterised by lower proliferation and metastatic potential than size-matched pure IDC, especially if the ratio of DCIS to IDC size is high. We submit that IDC-DCIS is biologically distinct from pure IDC, and propose an incremental molecular pathogenesis of IDC-DCIS evolution involving an intermediate DCIS precursor that remains dependent for replication on upstream mitogens. © 2010 Cancer Research UK All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/132643
ISSN
2015 Impact Factor: 5.569
2015 SCImago Journal Rankings: 2.939
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, Hen_HK
dc.contributor.authorLau, Sen_HK
dc.contributor.authorYau, Ten_HK
dc.contributor.authorCheung, Pen_HK
dc.contributor.authorEpstein, RJen_HK
dc.date.accessioned2011-03-28T09:27:20Z-
dc.date.available2011-03-28T09:27:20Z-
dc.date.issued2010en_HK
dc.identifier.citationBritish Journal Of Cancer, 2010, v. 102 n. 9, p. 1391-1396en_HK
dc.identifier.issn0007-0920en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132643-
dc.description.abstractBackground:The metastatic propensity of invasive ductal carcinoma (IDC) of the breast correlates with axillary node involvement and with expression of the proliferation antigen Ki-67, whereas ductal carcinoma in situ (DCIS) is non-metastasising. To clarify whether concomitant DCIS affects IDC prognosis, we compared Ki-67 expression and node status of size-matched IDC subgroups either with DCIS (IDC-DCIS) or without DCIS (pure IDC).Methods:We analysed data from 1355 breast cancer patients. End points were defined by the association of IDC (with or without DCIS) with grade, nodal status, Ki-67, and ER/HER2.Results: Size-matched IDC-DCIS was more likely than pure IDC to be screen detected (P0.03), to occur in pre-menopausal women (P0.002), and to be either ER-positive (P0.002) or HER2-positive (P0.0005), but less likely to be treated with breast-conserving surgery (P0.004). Grade and Ki-67 were lower in IDC-DCIS than in pure IDC (P0.02), and declined as the DCIS enlarged (P0.01). Node involvement and lymphovascular invasion in IDC-DCIS increased with the size ratio of IDC to DCIS (P0.01). A 60-month cancer-specific survival favoured IDC-DCIS over size-matched pure IDC (97.4 vs 96.0%).Conclusion:IDC co-existing with DCIS is characterised by lower proliferation and metastatic potential than size-matched pure IDC, especially if the ratio of DCIS to IDC size is high. We submit that IDC-DCIS is biologically distinct from pure IDC, and propose an incremental molecular pathogenesis of IDC-DCIS evolution involving an intermediate DCIS precursor that remains dependent for replication on upstream mitogens. © 2010 Cancer Research UK All rights reserved.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjcen_HK
dc.relation.ispartofBritish Journal of Canceren_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectBreast neoplasmsen_HK
dc.subjectCarcinogenesisen_HK
dc.subjectIntraductalen_HK
dc.subjectKi-67en_HK
dc.subjectPre-invasiveen_HK
dc.subjectTumour progressionen_HK
dc.titlePresence of an in situ component is associated with reduced biological aggressiveness of size-matched invasive breast canceren_HK
dc.typeArticleen_HK
dc.identifier.emailYau, T: tyaucc@hku.hken_HK
dc.identifier.emailEpstein, RJ: repstein@hku.hken_HK
dc.identifier.authorityYau, T=rp01466en_HK
dc.identifier.authorityEpstein, RJ=rp00501en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1038/sj.bjc.6605655en_HK
dc.identifier.pmid20424617-
dc.identifier.pmcidPMC2865763-
dc.identifier.scopuseid_2-s2.0-77951668699en_HK
dc.identifier.hkuros216956-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951668699&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume102en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1391en_HK
dc.identifier.epage1396en_HK
dc.identifier.eissn1532-1827-
dc.identifier.isiWOS:000277098900012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, H=23089414000en_HK
dc.identifier.scopusauthoridLau, S=36118928300en_HK
dc.identifier.scopusauthoridYau, T=23391533100en_HK
dc.identifier.scopusauthoridCheung, P=7202595368en_HK
dc.identifier.scopusauthoridEpstein, RJ=34975074500en_HK
dc.identifier.citeulike7100003-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats