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Article: Possible role of cyclic nucleotides in the mechanism of the protective effect of methylprednisolone on the hypoxic heart

TitlePossible role of cyclic nucleotides in the mechanism of the protective effect of methylprednisolone on the hypoxic heart
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1978
Citation
Journal Of Cyclic Nucleotide Research, 1978, v. 4 n. 3, p. 209-218 How to Cite?
AbstractThe isolated isovolumic rat heart was used as a model of cardiac hypoxia. Force of cardiac contraction and cardiac cyclic nucleotide levels (cyclic GMP and cyclic AMP) were monitored in hearts subjected to hypoxia for 5 min and allowed to recover by reoxygenation. Hearts were obtained from both control animals and animals pretreated with methylprednisolone at 18 hr and 1 hr prior to sacrifice. Myocardial levels of cyclic GMP which were significantly (p <0.05) elevated above control during all periods of hypoxia were found to be lower when hearts were pretreated with methylprednisolone prior to hypoxic exposure. Hearts of animals pretreated with methylprednisolone also demonstrated better recovery during reoxygenation than did control hearts. These studies suggest that methylprednisolone may be beneficial in the prevention of myocardial failure following hypoxia via a modulation in myocardial cyclic GMP content.
Persistent Identifierhttp://hdl.handle.net/10722/132595
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBusuttil, RWen_HK
dc.contributor.authorGraeff, RMen_HK
dc.contributor.authorGeorge, WJen_HK
dc.date.accessioned2011-03-28T09:26:36Z-
dc.date.available2011-03-28T09:26:36Z-
dc.date.issued1978en_HK
dc.identifier.citationJournal Of Cyclic Nucleotide Research, 1978, v. 4 n. 3, p. 209-218en_HK
dc.identifier.issn0095-1544en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132595-
dc.description.abstractThe isolated isovolumic rat heart was used as a model of cardiac hypoxia. Force of cardiac contraction and cardiac cyclic nucleotide levels (cyclic GMP and cyclic AMP) were monitored in hearts subjected to hypoxia for 5 min and allowed to recover by reoxygenation. Hearts were obtained from both control animals and animals pretreated with methylprednisolone at 18 hr and 1 hr prior to sacrifice. Myocardial levels of cyclic GMP which were significantly (p <0.05) elevated above control during all periods of hypoxia were found to be lower when hearts were pretreated with methylprednisolone prior to hypoxic exposure. Hearts of animals pretreated with methylprednisolone also demonstrated better recovery during reoxygenation than did control hearts. These studies suggest that methylprednisolone may be beneficial in the prevention of myocardial failure following hypoxia via a modulation in myocardial cyclic GMP content.en_HK
dc.languageengen_US
dc.relation.ispartofJournal of Cyclic Nucleotide Researchen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titlePossible role of cyclic nucleotides in the mechanism of the protective effect of methylprednisolone on the hypoxic hearten_HK
dc.typeArticleen_HK
dc.identifier.emailGraeff, RM: graeffr@hku.hken_HK
dc.identifier.authorityGraeff, RM=rp01464en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid214463-
dc.identifier.scopuseid_2-s2.0-0018144497en_HK
dc.identifier.volume4en_HK
dc.identifier.issue3en_HK
dc.identifier.spage209en_HK
dc.identifier.epage218en_HK
dc.identifier.isiWOS:A1978FE06800006-
dc.identifier.scopusauthoridBusuttil, RW=7101995142en_HK
dc.identifier.scopusauthoridGraeff, RM=7003614053en_HK
dc.identifier.scopusauthoridGeorge, WJ=7202536108en_HK

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