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Article: Cyclic ADP ribose activation of the ryanodine receptor is mediated by calmodulin

TitleCyclic ADP ribose activation of the ryanodine receptor is mediated by calmodulin
Authors
KeywordsSpecies Index: Animalia
Echinoidea
Issue Date1994
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 1994, v. 370 n. 6487, p. 307-309 How to Cite?
AbstractCyclic ADP-ribose (cADPR) is a newly identified nucleotide which can release calcium from a variety of cells, suggesting it is a messenger for mobilizing internal Ca2+ stores. Its cyclic structure has now been confirmed by X-ray crystallography. Available results are consistent with it being a modulator of Ca2+-induced Ca2+ release. Here we report that sea urchin egg microsomes purified by Percoll gradients lose sensitivity to cADPR, but the response can be restored by a soluble protein in the supernatant. Purification and characterization of the protein indicate that it is calmodulin. It appears to be sensitizing the Ca2+ release mechanism because caffeine and strontium, agonists of Ca2+-induced Ca2+ release, can also mimic calmodulin in conferring cADPR-sensitivity. Although evidence indicates that cADPR may be an activator of the ryanodine receptor, present results point to the importance of accessory proteins such as calmodulin in modulating its activity.
Persistent Identifierhttp://hdl.handle.net/10722/132585
ISSN
2015 Impact Factor: 38.138
2015 SCImago Journal Rankings: 21.936
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, HCen_HK
dc.contributor.authorAarhus, Ren_HK
dc.contributor.authorGraeff, Ren_HK
dc.contributor.authorGurnack, MEen_HK
dc.contributor.authorWalseth, TFen_HK
dc.date.accessioned2011-03-28T09:26:32Z-
dc.date.available2011-03-28T09:26:32Z-
dc.date.issued1994en_HK
dc.identifier.citationNature, 1994, v. 370 n. 6487, p. 307-309en_HK
dc.identifier.issn0028-0836en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132585-
dc.description.abstractCyclic ADP-ribose (cADPR) is a newly identified nucleotide which can release calcium from a variety of cells, suggesting it is a messenger for mobilizing internal Ca2+ stores. Its cyclic structure has now been confirmed by X-ray crystallography. Available results are consistent with it being a modulator of Ca2+-induced Ca2+ release. Here we report that sea urchin egg microsomes purified by Percoll gradients lose sensitivity to cADPR, but the response can be restored by a soluble protein in the supernatant. Purification and characterization of the protein indicate that it is calmodulin. It appears to be sensitizing the Ca2+ release mechanism because caffeine and strontium, agonists of Ca2+-induced Ca2+ release, can also mimic calmodulin in conferring cADPR-sensitivity. Although evidence indicates that cADPR may be an activator of the ryanodine receptor, present results point to the importance of accessory proteins such as calmodulin in modulating its activity.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_HK
dc.relation.ispartofNatureen_HK
dc.subjectSpecies Index: Animaliaen_US
dc.subjectEchinoideaen_US
dc.titleCyclic ADP ribose activation of the ryanodine receptor is mediated by calmodulinen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, HC: leehc@hku.hken_HK
dc.identifier.emailGraeff, R: graeffr@hku.hken_HK
dc.identifier.authorityLee, HC=rp00545en_HK
dc.identifier.authorityGraeff, R=rp01464en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/370307a0en_HK
dc.identifier.pmid8035880-
dc.identifier.scopuseid_2-s2.0-0028131433en_HK
dc.identifier.volume370en_HK
dc.identifier.issue6487en_HK
dc.identifier.spage307en_HK
dc.identifier.epage309en_HK
dc.identifier.isiWOS:A1994NZ22900068-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLee, HC=26642959100en_HK
dc.identifier.scopusauthoridAarhus, R=6701339421en_HK
dc.identifier.scopusauthoridGraeff, R=7003614053en_HK
dc.identifier.scopusauthoridGurnack, ME=6507584259en_HK
dc.identifier.scopusauthoridWalseth, TF=7005424273en_HK

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