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Article: Magnesium ions but not ATP inhibit cyclic ADP-ribose-induced calcium release

TitleMagnesium ions but not ATP inhibit cyclic ADP-ribose-induced calcium release
Authors
KeywordsSpecies Index: Echinoidea
Issue Date1995
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 1995, v. 206 n. 2, p. 786-791 How to Cite?
AbstractThe pharmacology of the cyclic ADP-ribose (cADPR)-dependent Ca+2 release mechanism is very similar to that of the ryanodine receptor (RyR). Here we showed that MgCl2, a known inhibitor of RyR, blocked cADPR-induced Ca+2 release in sea urchin egg homogenates with a half maximal concentration of about 2.5 mM. The effect was specific since up to 10 mM Mg+2 had no effect on the Ca+2 release induced by inositol trisphosphate. K2ATP, another known modulator of RyR, at up to 10 mM did not affect the half-maximal concentration of cADPR, which remained at about 96 nM. These results indicate cADPR is a specific Ca+2 release activator and not merely an adenine nucleotide acting on the ATP-site. The inhibitory effects of Mg+2 further demonstrate the similarity between RyR and the cADPR-dependent Ca+2 release system.
Persistent Identifierhttp://hdl.handle.net/10722/132582
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGraeff, RMen_HK
dc.contributor.authorPodein, RJen_HK
dc.contributor.authorAarhus, Ren_HK
dc.contributor.authorLee, HCen_HK
dc.date.accessioned2011-03-28T09:26:31Z-
dc.date.available2011-03-28T09:26:31Z-
dc.date.issued1995en_HK
dc.identifier.citationBiochemical And Biophysical Research Communications, 1995, v. 206 n. 2, p. 786-791en_HK
dc.identifier.issn0006-291Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/132582-
dc.description.abstractThe pharmacology of the cyclic ADP-ribose (cADPR)-dependent Ca+2 release mechanism is very similar to that of the ryanodine receptor (RyR). Here we showed that MgCl2, a known inhibitor of RyR, blocked cADPR-induced Ca+2 release in sea urchin egg homogenates with a half maximal concentration of about 2.5 mM. The effect was specific since up to 10 mM Mg+2 had no effect on the Ca+2 release induced by inositol trisphosphate. K2ATP, another known modulator of RyR, at up to 10 mM did not affect the half-maximal concentration of cADPR, which remained at about 96 nM. These results indicate cADPR is a specific Ca+2 release activator and not merely an adenine nucleotide acting on the ATP-site. The inhibitory effects of Mg+2 further demonstrate the similarity between RyR and the cADPR-dependent Ca+2 release system.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_HK
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_HK
dc.subjectSpecies Index: Echinoideaen_US
dc.titleMagnesium ions but not ATP inhibit cyclic ADP-ribose-induced calcium releaseen_HK
dc.typeArticleen_HK
dc.identifier.emailGraeff, RM: graeffr@hku.hken_HK
dc.identifier.emailLee, HC: leehc@hku.hken_HK
dc.identifier.authorityGraeff, RM=rp01464en_HK
dc.identifier.authorityLee, HC=rp00545en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/bbrc.1995.1111en_HK
dc.identifier.pmid7826401-
dc.identifier.scopuseid_2-s2.0-0028897336en_HK
dc.identifier.volume206en_HK
dc.identifier.issue2en_HK
dc.identifier.spage786en_HK
dc.identifier.epage791en_HK
dc.identifier.isiWOS:A1995QC11500050-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGraeff, RM=7003614053en_HK
dc.identifier.scopusauthoridPodein, RJ=6507116194en_HK
dc.identifier.scopusauthoridAarhus, R=6701339421en_HK
dc.identifier.scopusauthoridLee, HC=26642959100en_HK

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