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Article: Modified vaccination technique for prophylactic and therapeutic applications to combat endogenous antigen-induced disorders

TitleModified vaccination technique for prophylactic and therapeutic applications to combat endogenous antigen-induced disorders
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2010
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/SJI
Citation
Scandinavian Journal Of Immunology, 2010, v. 71 n. 3, p. 125-133 How to Cite?
AbstractPublic health can be protected most effectively through vaccination programmes. However, while presently available vaccination techniques protects the individual by provoking immune responses against exogenous antigens (ags), such as those associated with certain bacteria and viruses, they cannot protect against or treat mishaps caused by endogenous ag. Recently, Barabas and colleagues have developed a new vaccination method, called modified vaccination technique (MVT), which allows the presentation of disease causing agents in such a way as to initiate and maintain desired immune response outcomes even in the context of mishaps associated with endogenous ag. For example, in an experimental autoimmune kidney disease, the MVT downregulated/terminated pathogenic immune responses that were causing morphological and functional changes of the kidney. The MVT promises, with appropriate case-specific modifications, both preventative and curative applications for ailments, such as endogenous ag initiated mishaps (i.e. autoimmune diseases and cancer) and diseases caused by chronic infection, that are presently only treatable with drugs. To achieve specific immune responses, purified components of the vaccine (ag and antibodies) must be produced and assembled into immune complexes having the potential of inducing predetermined corrective immune response outcomes. © 2010 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/132544
ISSN
2015 Impact Factor: 2.27
2015 SCImago Journal Rankings: 0.934
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBarabas, AZen_HK
dc.contributor.authorCole, CDen_HK
dc.contributor.authorBarabas, ADen_HK
dc.contributor.authorGraeff, RMen_HK
dc.contributor.authorLafreniere, Ren_HK
dc.contributor.authorWeir, DMen_HK
dc.date.accessioned2011-03-28T09:26:09Z-
dc.date.available2011-03-28T09:26:09Z-
dc.date.issued2010en_HK
dc.identifier.citationScandinavian Journal Of Immunology, 2010, v. 71 n. 3, p. 125-133en_HK
dc.identifier.issn0300-9475en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132544-
dc.description.abstractPublic health can be protected most effectively through vaccination programmes. However, while presently available vaccination techniques protects the individual by provoking immune responses against exogenous antigens (ags), such as those associated with certain bacteria and viruses, they cannot protect against or treat mishaps caused by endogenous ag. Recently, Barabas and colleagues have developed a new vaccination method, called modified vaccination technique (MVT), which allows the presentation of disease causing agents in such a way as to initiate and maintain desired immune response outcomes even in the context of mishaps associated with endogenous ag. For example, in an experimental autoimmune kidney disease, the MVT downregulated/terminated pathogenic immune responses that were causing morphological and functional changes of the kidney. The MVT promises, with appropriate case-specific modifications, both preventative and curative applications for ailments, such as endogenous ag initiated mishaps (i.e. autoimmune diseases and cancer) and diseases caused by chronic infection, that are presently only treatable with drugs. To achieve specific immune responses, purified components of the vaccine (ag and antibodies) must be produced and assembled into immune complexes having the potential of inducing predetermined corrective immune response outcomes. © 2010 Blackwell Publishing Ltd.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/SJIen_HK
dc.relation.ispartofScandinavian Journal of Immunologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleModified vaccination technique for prophylactic and therapeutic applications to combat endogenous antigen-induced disordersen_HK
dc.typeArticleen_HK
dc.identifier.emailGraeff, RM: graeffr@hku.hken_HK
dc.identifier.authorityGraeff, RM=rp01464en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-3083.2009.02360.xen_HK
dc.identifier.pmid20415778-
dc.identifier.scopuseid_2-s2.0-77449128483en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77449128483&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume71en_HK
dc.identifier.issue3en_HK
dc.identifier.spage125en_HK
dc.identifier.epage133en_HK
dc.identifier.eissn1365-3083-
dc.identifier.isiWOS:000274805900001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBarabas, AZ=7005562572en_HK
dc.identifier.scopusauthoridCole, CD=8942475100en_HK
dc.identifier.scopusauthoridBarabas, AD=7005562583en_HK
dc.identifier.scopusauthoridGraeff, RM=7003614053en_HK
dc.identifier.scopusauthoridLafreniere, R=7006983863en_HK
dc.identifier.scopusauthoridWeir, DM=7202838101en_HK
dc.identifier.citeulike6801041-

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