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Article: DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity

TitleDANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2006
PublisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/
Citation
Journal Of Biological Chemistry, 2006, v. 281 n. 48, p. 37111-37116 How to Cite?
AbstractWe report the cloning and characterization of DANGER, a novel protein which physiologically binds to inositol 1,4,5-trisphosphate receptors (IP 3R). DANGER is a membrane-associated protein predicted to contain a partial MAB-21 domain. It is expressed in a wide variety of neuronal cell lineages where it localizes to membranes in the cell periphery together with IP3R. DANGER interacts with IP3R in vitro and co-immunoprecipitates with IP3R from cellular preparations. DANGER robustly enhances Ca2+-mediated inhibition of IP3R Ca 2+ release without affecting IP3 binding in microsomal assays and inhibits gating in single-channel recordings of IP3R. DANGER appears to allosterically modulate the sensitivity of IP3R to Ca2+ inhibition, which likely alters IP3R-mediated Ca 2+ dynamics in cells where DANGER and IP3R are co-expressed. © 2006 by The American Society for Biochemistry and Molecular Biology, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/132538
ISSN
2015 Impact Factor: 4.258
2015 SCImago Journal Rankings: 3.151
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVan Rossum, DBen_HK
dc.contributor.authorPatterson, RLen_HK
dc.contributor.authorCheung, KHen_HK
dc.contributor.authorBarrow, RKen_HK
dc.contributor.authorSyrovatkina, Ven_HK
dc.contributor.authorGessell, GSen_HK
dc.contributor.authorBurkholder, SGen_HK
dc.contributor.authorWatkins, DNen_HK
dc.contributor.authorFoskett, JKen_HK
dc.contributor.authorSnyder, SHen_HK
dc.date.accessioned2011-03-28T09:26:05Z-
dc.date.available2011-03-28T09:26:05Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Biological Chemistry, 2006, v. 281 n. 48, p. 37111-37116en_HK
dc.identifier.issn0021-9258en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132538-
dc.description.abstractWe report the cloning and characterization of DANGER, a novel protein which physiologically binds to inositol 1,4,5-trisphosphate receptors (IP 3R). DANGER is a membrane-associated protein predicted to contain a partial MAB-21 domain. It is expressed in a wide variety of neuronal cell lineages where it localizes to membranes in the cell periphery together with IP3R. DANGER interacts with IP3R in vitro and co-immunoprecipitates with IP3R from cellular preparations. DANGER robustly enhances Ca2+-mediated inhibition of IP3R Ca 2+ release without affecting IP3 binding in microsomal assays and inhibits gating in single-channel recordings of IP3R. DANGER appears to allosterically modulate the sensitivity of IP3R to Ca2+ inhibition, which likely alters IP3R-mediated Ca 2+ dynamics in cells where DANGER and IP3R are co-expressed. © 2006 by The American Society for Biochemistry and Molecular Biology, Inc.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/en_HK
dc.relation.ispartofJournal of Biological Chemistryen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleDANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activityen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, KH: kingho.cheung@hku.hken_HK
dc.identifier.authorityCheung, KH=rp01463en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1074/jbc.M608760200en_HK
dc.identifier.pmid16990268-
dc.identifier.scopuseid_2-s2.0-33846031944en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846031944&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume281en_HK
dc.identifier.issue48en_HK
dc.identifier.spage37111en_HK
dc.identifier.epage37116en_HK
dc.identifier.eissn1083-351X-
dc.identifier.isiWOS:000242220800072-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridVan Rossum, DB=7004262055en_HK
dc.identifier.scopusauthoridPatterson, RL=7403567300en_HK
dc.identifier.scopusauthoridCheung, KH=14007487800en_HK
dc.identifier.scopusauthoridBarrow, RK=7006840766en_HK
dc.identifier.scopusauthoridSyrovatkina, V=15758653100en_HK
dc.identifier.scopusauthoridGessell, GS=15757790800en_HK
dc.identifier.scopusauthoridBurkholder, SG=6603448696en_HK
dc.identifier.scopusauthoridWatkins, DN=7203077801en_HK
dc.identifier.scopusauthoridFoskett, JK=7005723620en_HK
dc.identifier.scopusauthoridSnyder, SH=35406091300en_HK

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