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Article: Inositol trisphosphate receptor Ca2+ release channels

TitleInositol trisphosphate receptor Ca2+ release channels
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2007
PublisherAmerican Physiological Society
Citation
Physiological Reviews, 2007, v. 87 n. 2, p. 593-658 How to Cite?
AbstractThe inositol 1,4,5-trisphosphate (InsP3) receptors (InsP 3Rs) are a family of Ca2+ release channels localized predominately in the endoplasmic reticulum of all cell types. They function to release Ca2+ into the cytoplasm in response to InsP3 produced by diverse stimuli, generating complex local and global Ca2+ signals that regulate numerous cell physiological processes ranging from gene transcription to secretion to learning and memory. The InsP3R is a calcium-selective cation channel whose gating is regulated not only by InsP 3, but by other ligands as well, in particular cytoplasmic Ca 2+. Over the last decade, detailed quantitative studies of InsP 3R channel function and its regulation by ligands and interacting proteins have provided new insights into a remarkable richness of channel regulation and of the structural aspects that underlie signal transduction and permeation. Here, we focus on these developments and review and synthesize the literature regarding the structure and single-channel properties of the InsP3R. Copyright © 2007 the American Physiological Society.
Persistent Identifierhttp://hdl.handle.net/10722/132537
ISSN
2015 Impact Factor: 30.924
2015 SCImago Journal Rankings: 17.564
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFoskett, JKen_HK
dc.contributor.authorWhite, Cen_HK
dc.contributor.authorCheung, KHen_HK
dc.contributor.authorMak, DODen_HK
dc.date.accessioned2011-03-28T09:26:04Z-
dc.date.available2011-03-28T09:26:04Z-
dc.date.issued2007en_HK
dc.identifier.citationPhysiological Reviews, 2007, v. 87 n. 2, p. 593-658en_HK
dc.identifier.issn0031-9333en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132537-
dc.description.abstractThe inositol 1,4,5-trisphosphate (InsP3) receptors (InsP 3Rs) are a family of Ca2+ release channels localized predominately in the endoplasmic reticulum of all cell types. They function to release Ca2+ into the cytoplasm in response to InsP3 produced by diverse stimuli, generating complex local and global Ca2+ signals that regulate numerous cell physiological processes ranging from gene transcription to secretion to learning and memory. The InsP3R is a calcium-selective cation channel whose gating is regulated not only by InsP 3, but by other ligands as well, in particular cytoplasmic Ca 2+. Over the last decade, detailed quantitative studies of InsP 3R channel function and its regulation by ligands and interacting proteins have provided new insights into a remarkable richness of channel regulation and of the structural aspects that underlie signal transduction and permeation. Here, we focus on these developments and review and synthesize the literature regarding the structure and single-channel properties of the InsP3R. Copyright © 2007 the American Physiological Society.en_HK
dc.languageengen_US
dc.publisherAmerican Physiological Societyen_US
dc.relation.ispartofPhysiological Reviewsen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleInositol trisphosphate receptor Ca2+ release channelsen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, KH: kingho.cheung@hku.hken_HK
dc.identifier.authorityCheung, KH=rp01463en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1152/physrev.00035.2006en_HK
dc.identifier.pmid17429043en_HK
dc.identifier.pmcidPMC2901638-
dc.identifier.scopuseid_2-s2.0-34248584090en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34248584090&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume87en_HK
dc.identifier.issue2en_HK
dc.identifier.spage593en_HK
dc.identifier.epage658en_HK
dc.identifier.eissn1522-1210-
dc.identifier.isiWOS:000248378800007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFoskett, JK=7005723620en_HK
dc.identifier.scopusauthoridWhite, C=7404153650en_HK
dc.identifier.scopusauthoridCheung, KH=14007487800en_HK
dc.identifier.scopusauthoridMak, DOD=35587181700en_HK
dc.identifier.citeulike6011923-

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