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Article: Subtle effects on myelin basic protein-specific T cell responses can lead to a major reduction in disease susceptibility in experimental allergic encephalomyelitis

TitleSubtle effects on myelin basic protein-specific T cell responses can lead to a major reduction in disease susceptibility in experimental allergic encephalomyelitis
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2000
PublisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
Citation
Journal Of Immunology, 2000, v. 165 n. 1, p. 75-82 How to Cite?
AbstractThe presence of potentially autoreactive T cells is a necessary, but not sufficient, condition for the development of autoimmune disease. However, the relationship between T cell response and susceptibility to disease is not straightforward. In this report, we use experimental allergic encephalomyelitis as a model to demonstrate that subtle alterations of the T cell response to an encephalitogenic epitope are sufficient to cause a dramatic decrease in disease susceptibility. Transgenic expression of a fusion protein of hen egg lysozyme and an encephalitogenic peptide of myelin basic protein (MBP) residues 84-105, coexpressed with MHC class H, causes profound tolerance to hen egg lysozyme, while maintaining a near normal response to MBP. Detailed analysis of the T cell repertoire of transgenic animals using a panel of T cell hybridomas revealed a highly selective loss of one minor component of the response to the MBP84-104 region. Despite this, transgenic animals were highly resistant to experimental allergic encephalomyelitis induction with the MBP peptide, indicating that minor changes to the T cell repertoire may result in major alterations in disease susceptibility. Possible reasons for this are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/132504
ISSN
2015 Impact Factor: 4.985
2015 SCImago Journal Rankings: 3.549
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVowles, Cen_HK
dc.contributor.authorChan, VSFen_HK
dc.contributor.authorBodmer, HCen_HK
dc.date.accessioned2011-03-28T09:25:30Z-
dc.date.available2011-03-28T09:25:30Z-
dc.date.issued2000en_HK
dc.identifier.citationJournal Of Immunology, 2000, v. 165 n. 1, p. 75-82en_HK
dc.identifier.issn0022-1767en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132504-
dc.description.abstractThe presence of potentially autoreactive T cells is a necessary, but not sufficient, condition for the development of autoimmune disease. However, the relationship between T cell response and susceptibility to disease is not straightforward. In this report, we use experimental allergic encephalomyelitis as a model to demonstrate that subtle alterations of the T cell response to an encephalitogenic epitope are sufficient to cause a dramatic decrease in disease susceptibility. Transgenic expression of a fusion protein of hen egg lysozyme and an encephalitogenic peptide of myelin basic protein (MBP) residues 84-105, coexpressed with MHC class H, causes profound tolerance to hen egg lysozyme, while maintaining a near normal response to MBP. Detailed analysis of the T cell repertoire of transgenic animals using a panel of T cell hybridomas revealed a highly selective loss of one minor component of the response to the MBP84-104 region. Despite this, transgenic animals were highly resistant to experimental allergic encephalomyelitis induction with the MBP peptide, indicating that minor changes to the T cell repertoire may result in major alterations in disease susceptibility. Possible reasons for this are discussed.en_HK
dc.languageengen_US
dc.publisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.orgen_HK
dc.relation.ispartofJournal of Immunologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.subject.meshAmino Acid Sequenceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAntigen Presentation - geneticsen_HK
dc.subject.meshAntigen-Presenting Cells - immunology - metabolismen_HK
dc.subject.meshDisease Susceptibilityen_HK
dc.subject.meshEncephalomyelitis, Autoimmune, Experimental - genetics - immunologyen_HK
dc.subject.meshEpitopes, T-Lymphocyte - immunologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHistocompatibility Antigens Class II - genetics - immunology - metabolismen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred Strainsen_HK
dc.subject.meshMice, Transgenicen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshMuramidase - genetics - immunology - metabolismen_HK
dc.subject.meshMyelin Basic Proteins - genetics - immunology - metabolismen_HK
dc.subject.meshPeptide Fragments - genetics - immunology - metabolismen_HK
dc.subject.meshSpleen - cytologyen_HK
dc.subject.meshT-Lymphocytes - immunology - metabolismen_HK
dc.subject.meshTransgenes - immunologyen_HK
dc.titleSubtle effects on myelin basic protein-specific T cell responses can lead to a major reduction in disease susceptibility in experimental allergic encephalomyelitisen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, VSF:sfvchan@hku.hken_HK
dc.identifier.authorityChan, VSF=rp01459en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10861037-
dc.identifier.scopuseid_2-s2.0-0034235813en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034235813&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume165en_HK
dc.identifier.issue1en_HK
dc.identifier.spage75en_HK
dc.identifier.epage82en_HK
dc.identifier.isiWOS:000087816800012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridVowles, C=8234331000en_HK
dc.identifier.scopusauthoridChan, VSF=35200370000en_HK
dc.identifier.scopusauthoridBodmer, HC=6701765081en_HK

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