File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: ICOS is essential for effective T-helper-cell responses

TitleICOS is essential for effective T-helper-cell responses
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2001
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 2001, v. 409 n. 6816, p. 105-109 How to Cite?
AbstractThe outcome of T-cell responses after T-cell encounter with specific antigens is modulated by co-stimulatory signals, which are required for both lymphocyte activation and development of adaptive immunity1-3. ICOS4,5, an inducible co-stimulator with homology to CD28, is expressed on activated, but not resting T cells, and shows T-cell co-stimulatory function in vitro. ICOS binds specifically to its counter-receptor B7RP-1 (refs 5-7), but not to B7-1 or B7-2. Here we provide in vivo genetic evidence that ICOS delivers a co-stimulatory signal that is essential both for efficient interaction between T and B cells and for normal antibody responses to T-cell-dependent antigens. To determine the physiological function of ICOS, we generated and characterized gene-targeted ICOS-deficient mice. In vivo, a lack of ICOS results in severely deficient T-cell-dependent B-cell responses. Germinal centre formation is impaired and immunoglobulin class switching, including production of allergy-mediating IgE, is defective. ICOS-deficient T cells primed in in vivo and restimulated in vitro with specific antigen produce only low levels of interleukin-4, but remain fully competent to produce interferon-γ.
Persistent Identifierhttp://hdl.handle.net/10722/132503
ISSN
2015 Impact Factor: 38.138
2015 SCImago Journal Rankings: 21.936
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTafuri, Aen_HK
dc.contributor.authorShahinian, Aen_HK
dc.contributor.authorBladt, Fen_HK
dc.contributor.authorYoshinaga, SKen_HK
dc.contributor.authorJordana, Men_HK
dc.contributor.authorWakeham, Aen_HK
dc.contributor.authorBoucher, LMen_HK
dc.contributor.authorBouchard, Den_HK
dc.contributor.authorChan, VSFen_HK
dc.contributor.authorDuncan, Gen_HK
dc.contributor.authorOdermatt, Ben_HK
dc.contributor.authorHo, Aen_HK
dc.contributor.authorItie, Aen_HK
dc.contributor.authorHoran, Ten_HK
dc.contributor.authorWhoriskey, JSen_HK
dc.contributor.authorPawson, Ten_HK
dc.contributor.authorPenninger, JMen_HK
dc.contributor.authorOhashi, PSen_HK
dc.contributor.authorMak, TWen_HK
dc.date.accessioned2011-03-28T09:25:29Z-
dc.date.available2011-03-28T09:25:29Z-
dc.date.issued2001en_HK
dc.identifier.citationNature, 2001, v. 409 n. 6816, p. 105-109en_HK
dc.identifier.issn0028-0836en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132503-
dc.description.abstractThe outcome of T-cell responses after T-cell encounter with specific antigens is modulated by co-stimulatory signals, which are required for both lymphocyte activation and development of adaptive immunity1-3. ICOS4,5, an inducible co-stimulator with homology to CD28, is expressed on activated, but not resting T cells, and shows T-cell co-stimulatory function in vitro. ICOS binds specifically to its counter-receptor B7RP-1 (refs 5-7), but not to B7-1 or B7-2. Here we provide in vivo genetic evidence that ICOS delivers a co-stimulatory signal that is essential both for efficient interaction between T and B cells and for normal antibody responses to T-cell-dependent antigens. To determine the physiological function of ICOS, we generated and characterized gene-targeted ICOS-deficient mice. In vivo, a lack of ICOS results in severely deficient T-cell-dependent B-cell responses. Germinal centre formation is impaired and immunoglobulin class switching, including production of allergy-mediating IgE, is defective. ICOS-deficient T cells primed in in vivo and restimulated in vitro with specific antigen produce only low levels of interleukin-4, but remain fully competent to produce interferon-γ.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_HK
dc.relation.ispartofNatureen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.subject.meshAnimalsen_HK
dc.subject.meshAntigens - immunologyen_HK
dc.subject.meshAntigens, Differentiation, T-Lymphocyte - genetics - physiologyen_HK
dc.subject.meshB-Lymphocytes - immunologyen_HK
dc.subject.meshCell Communicationen_HK
dc.subject.meshCell Divisionen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFicoll - analogs & derivatives - immunologyen_HK
dc.subject.meshFlow Cytometryen_HK
dc.subject.meshGene Targetingen_HK
dc.subject.meshGerminal Center - physiologyen_HK
dc.subject.meshHemocyanin - immunologyen_HK
dc.subject.meshImmunoglobulin Class Switchingen_HK
dc.subject.meshImmunoglobulin G - immunologyen_HK
dc.subject.meshInducible T-Cell Co-Stimulator Proteinen_HK
dc.subject.meshInterferon-gamma - biosynthesis - physiologyen_HK
dc.subject.meshInterleukin-4 - biosynthesis - physiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred C57BLen_HK
dc.subject.meshT-Lymphocytes, Helper-Inducer - immunology - physiologyen_HK
dc.subject.meshTrinitrobenzenes - immunologyen_HK
dc.titleICOS is essential for effective T-helper-cell responsesen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, VSF:sfvchan@hku.hken_HK
dc.identifier.authorityChan, VSF=rp01459en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/35051113en_HK
dc.identifier.pmid11343123-
dc.identifier.scopuseid_2-s2.0-0035804269en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035804269&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume409en_HK
dc.identifier.issue6816en_HK
dc.identifier.spage105en_HK
dc.identifier.epage109en_HK
dc.identifier.isiWOS:000166175600049-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTafuri, A=7005452786en_HK
dc.identifier.scopusauthoridShahinian, A=7004127534en_HK
dc.identifier.scopusauthoridBladt, F=6603009862en_HK
dc.identifier.scopusauthoridYoshinaga, SK=7006289692en_HK
dc.identifier.scopusauthoridJordana, M=7006735801en_HK
dc.identifier.scopusauthoridWakeham, A=7003944156en_HK
dc.identifier.scopusauthoridBoucher, LM=35977678900en_HK
dc.identifier.scopusauthoridBouchard, D=8747658200en_HK
dc.identifier.scopusauthoridChan, VSF=35200370000en_HK
dc.identifier.scopusauthoridDuncan, G=7202600001en_HK
dc.identifier.scopusauthoridOdermatt, B=7006054093en_HK
dc.identifier.scopusauthoridHo, A=7402675088en_HK
dc.identifier.scopusauthoridItie, A=6602701141en_HK
dc.identifier.scopusauthoridHoran, T=7005554026en_HK
dc.identifier.scopusauthoridWhoriskey, JS=6508360623en_HK
dc.identifier.scopusauthoridPawson, T=35378370700en_HK
dc.identifier.scopusauthoridPenninger, JM=35419243000en_HK
dc.identifier.scopusauthoridOhashi, PS=7006493798en_HK
dc.identifier.scopusauthoridMak, TW=7401931099en_HK
dc.identifier.citeulike4860896-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats