File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Role of ICOS versus CD28 in antiviral immunity

TitleRole of ICOS versus CD28 in antiviral immunity
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2002
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.eji.de
Citation
European Journal Of Immunology, 2002, v. 32 n. 12, p. 3376-3385 How to Cite?
AbstractThe costimulatory protein ICOS is inducibly expressed on activated T cells. Previous results have shown that ICOS-/- mice are defective in germinal center formation, antibody (Ab) production and class switch as well as Th1 and Th2 cytokine production in response to protein or parasite antigens. However, ICOS-Ig failed to block antiviral Ab responses. To date the immune response to viruses has not been examined in ICOS-/- mice. In this report we compared antiviral Ab responses to LCMV, VSV and influenza virus in ICOS-/- versus wild-type mice. Our results show that ICOS is important in the Ab response to all three viruses, with greater effects on primary as compared to secondary responses. Although ICOS-/- mice are impaired in some immune responses following influenza infection, the effects were less severe than for CD28-/- mice. There was no defect in initial influenza-specific CD8 T cell expansion in ICOS-/- mice or in cytotoxic effector function. However, ICOS was important in maintaining CD4 cytokine production and CD8 T cell numbers late in the primary response. Upon secondary infection, ICOS-/- mice show wild-type levels of influenza-specific CD8 T cells, whereas CD28-/1- mice show greatly impaired secondary CD8 T cell expansion. Overall, our results show that ICOS plays a clear role in the primary response to viruses at the level of Ab production, germinal center formation and Th cytokine production, but has diminished effects following secondary viral challenge.
Persistent Identifierhttp://hdl.handle.net/10722/132500
ISSN
2015 Impact Factor: 4.179
2015 SCImago Journal Rankings: 2.568
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBertram, EMen_HK
dc.contributor.authorTafuri, Aen_HK
dc.contributor.authorShahinian, Aen_HK
dc.contributor.authorChan, VSFen_HK
dc.contributor.authorHunziker, Len_HK
dc.contributor.authorRecher, Men_HK
dc.contributor.authorOhashi, PSen_HK
dc.contributor.authorMak, TWen_HK
dc.contributor.authorWatts, THen_HK
dc.date.accessioned2011-03-28T09:25:27Z-
dc.date.available2011-03-28T09:25:27Z-
dc.date.issued2002en_HK
dc.identifier.citationEuropean Journal Of Immunology, 2002, v. 32 n. 12, p. 3376-3385en_HK
dc.identifier.issn0014-2980en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132500-
dc.description.abstractThe costimulatory protein ICOS is inducibly expressed on activated T cells. Previous results have shown that ICOS-/- mice are defective in germinal center formation, antibody (Ab) production and class switch as well as Th1 and Th2 cytokine production in response to protein or parasite antigens. However, ICOS-Ig failed to block antiviral Ab responses. To date the immune response to viruses has not been examined in ICOS-/- mice. In this report we compared antiviral Ab responses to LCMV, VSV and influenza virus in ICOS-/- versus wild-type mice. Our results show that ICOS is important in the Ab response to all three viruses, with greater effects on primary as compared to secondary responses. Although ICOS-/- mice are impaired in some immune responses following influenza infection, the effects were less severe than for CD28-/- mice. There was no defect in initial influenza-specific CD8 T cell expansion in ICOS-/- mice or in cytotoxic effector function. However, ICOS was important in maintaining CD4 cytokine production and CD8 T cell numbers late in the primary response. Upon secondary infection, ICOS-/- mice show wild-type levels of influenza-specific CD8 T cells, whereas CD28-/1- mice show greatly impaired secondary CD8 T cell expansion. Overall, our results show that ICOS plays a clear role in the primary response to viruses at the level of Ab production, germinal center formation and Th cytokine production, but has diminished effects following secondary viral challenge.en_HK
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.eji.deen_HK
dc.relation.ispartofEuropean Journal of Immunologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.subject.meshAnimalsen_HK
dc.subject.meshAntibodies, Viral - biosynthesisen_HK
dc.subject.meshAntigens, CD28 - metabolismen_HK
dc.subject.meshAntigens, Differentiation, T-Lymphocyte - genetics - metabolismen_HK
dc.subject.meshCD4-Positive T-Lymphocytes - immunologyen_HK
dc.subject.meshCD8-Positive T-Lymphocytes - immunologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshImmunoglobulin G - biosynthesis - classificationen_HK
dc.subject.meshImmunoglobulin Switch Regionen_HK
dc.subject.meshInducible T-Cell Co-Stimulator Proteinen_HK
dc.subject.meshInterleukin-2 - biosynthesisen_HK
dc.subject.meshLymphocytic choriomeningitis virus - immunologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred C57BLen_HK
dc.subject.meshMice, Knockouten_HK
dc.subject.meshOrthomyxoviridae - immunologyen_HK
dc.subject.meshOrthomyxoviridae Infections - immunologyen_HK
dc.subject.meshVesicular stomatitis Indiana virus - immunologyen_HK
dc.subject.meshViruses - immunologyen_HK
dc.titleRole of ICOS versus CD28 in antiviral immunityen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, VSF:sfvchan@hku.hken_HK
dc.identifier.authorityChan, VSF=rp01459en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/1521-4141(2002012)32:12<3376::AID-IMMU3376>3.0.CO;2-Gen_HK
dc.identifier.pmid12432568-
dc.identifier.scopuseid_2-s2.0-0036918725en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036918725&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue12en_HK
dc.identifier.spage3376en_HK
dc.identifier.epage3385en_HK
dc.identifier.isiWOS:000179907000005-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridBertram, EM=7005327792en_HK
dc.identifier.scopusauthoridTafuri, A=7005452786en_HK
dc.identifier.scopusauthoridShahinian, A=7004127534en_HK
dc.identifier.scopusauthoridChan, VSF=35200370000en_HK
dc.identifier.scopusauthoridHunziker, L=6603681276en_HK
dc.identifier.scopusauthoridRecher, M=6602499065en_HK
dc.identifier.scopusauthoridOhashi, PS=7006493798en_HK
dc.identifier.scopusauthoridMak, TW=7401931099en_HK
dc.identifier.scopusauthoridWatts, TH=7103338100en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats