Article: Dendritic cells: Sentinels against pathogens

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TitleDendritic cells: Sentinels against pathogens
AuthorsChung, NPY1
Chen, Y1
Chan, VSF1
Tam, PKH1
Lin, CLS1
KeywordsSpecies Index: Human Immunodeficiency Virus
Issue Date2004
PublisherHistology and Histopathology. The Journal's web site is located at http://www.hh.um.es
CitationHistology And Histopathology, 2004, v. 19 n. 1, p. 317-324 [How to Cite?]
AbstractDendritic cells (DCs) are the most potent antigen-presenting cells, and are regarded as "natural adjuvants" for the induction of primary T or T-dependent immunity. DCs in the peripheral sites capture and process antigens. Encounter of exogenous or endogenous stimuli mature the function of DCs, and they thus acquire T-cell stimulatory capacity and distinct chemotactic behavior which enables them to migrate to lymphoid tissue. In the secondary lymphoid organs, they present antigens to T- and B-cells and stimulate their proliferation. Dendritic cells are also involved in tolerance induction, in particular, to self antigens. DCs also play a key role in the transmission of many pathogens, and therefore may become targets for designing new therapies. DCs have been manipulated in vitro and in vivo for cancer immunotherapy. In this article, we provide a concise overview of DC biology and its current and future role in clinical settings.
ISSN0213-3911
2011 Impact Factor: 2.48
2011 SCImago Journal Rankings: 0.215
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChung, NPY
dc.contributor.authorChen, Y
dc.contributor.authorChan, VSF
dc.contributor.authorTam, PKH
dc.contributor.authorLin, CLS
dc.date.accessioned2011-03-28T09:25:26Z
dc.date.available2011-03-28T09:25:26Z
dc.date.issued2004
dc.description.abstractDendritic cells (DCs) are the most potent antigen-presenting cells, and are regarded as "natural adjuvants" for the induction of primary T or T-dependent immunity. DCs in the peripheral sites capture and process antigens. Encounter of exogenous or endogenous stimuli mature the function of DCs, and they thus acquire T-cell stimulatory capacity and distinct chemotactic behavior which enables them to migrate to lymphoid tissue. In the secondary lymphoid organs, they present antigens to T- and B-cells and stimulate their proliferation. Dendritic cells are also involved in tolerance induction, in particular, to self antigens. DCs also play a key role in the transmission of many pathogens, and therefore may become targets for designing new therapies. DCs have been manipulated in vitro and in vivo for cancer immunotherapy. In this article, we provide a concise overview of DC biology and its current and future role in clinical settings.
dc.description.naturelink_to_subscribed_fulltext
dc.identifier.citationHistology And Histopathology, 2004, v. 19 n. 1, p. 317-324 [How to Cite?]
dc.identifier.epage324
dc.identifier.hkuros89125
dc.identifier.isiWOS:000188355400037
dc.identifier.issn0213-3911
2011 Impact Factor: 2.48
2011 SCImago Journal Rankings: 0.215
dc.identifier.issue1
dc.identifier.pmid14702200
dc.identifier.scopuseid_2-s2.0-1642515006
dc.identifier.spage317
dc.identifier.urihttp://hdl.handle.net/10722/132498
dc.identifier.volume19
dc.languageeng
dc.publisherHistology and Histopathology. The Journal's web site is located at http://www.hh.um.es
dc.publisher.placeSpain
dc.relation.ispartofHistology and Histopathology
dc.relation.referencesReferences in Scopus
dc.subject.meshAnimals
dc.subject.meshAntigen Presentation
dc.subject.meshCell Division
dc.subject.meshCell Movement
dc.subject.meshDendritic Cells - physiology
dc.subject.meshHumans
dc.subject.meshImmune Tolerance
dc.subject.meshImmunotherapy
dc.subject.meshModels, Biological
dc.subject.meshNeoplasms - therapy
dc.subject.meshT-Lymphocytes - metabolism
dc.subjectSpecies Index: Human Immunodeficiency Virus
dc.titleDendritic cells: Sentinels against pathogens
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong