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Article: Dendritic cells: Sentinels against pathogens

TitleDendritic cells: Sentinels against pathogens
Authors
KeywordsSpecies Index: Human Immunodeficiency Virus
Issue Date2004
PublisherHistology and Histopathology. The Journal's web site is located at http://www.hh.um.es
Citation
Histology And Histopathology, 2004, v. 19 n. 1, p. 317-324 How to Cite?
Abstract
Dendritic cells (DCs) are the most potent antigen-presenting cells, and are regarded as "natural adjuvants" for the induction of primary T or T-dependent immunity. DCs in the peripheral sites capture and process antigens. Encounter of exogenous or endogenous stimuli mature the function of DCs, and they thus acquire T-cell stimulatory capacity and distinct chemotactic behavior which enables them to migrate to lymphoid tissue. In the secondary lymphoid organs, they present antigens to T- and B-cells and stimulate their proliferation. Dendritic cells are also involved in tolerance induction, in particular, to self antigens. DCs also play a key role in the transmission of many pathogens, and therefore may become targets for designing new therapies. DCs have been manipulated in vitro and in vivo for cancer immunotherapy. In this article, we provide a concise overview of DC biology and its current and future role in clinical settings.
Persistent Identifierhttp://hdl.handle.net/10722/132498
ISSN
2013 Impact Factor: 2.236
2013 SCImago Journal Rankings: 1.107
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorChung, NPYen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorChan, VSFen_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorLin, CLSen_HK
dc.date.accessioned2011-03-28T09:25:26Z-
dc.date.available2011-03-28T09:25:26Z-
dc.date.issued2004en_HK
dc.identifier.citationHistology And Histopathology, 2004, v. 19 n. 1, p. 317-324en_HK
dc.identifier.issn0213-3911en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132498-
dc.description.abstractDendritic cells (DCs) are the most potent antigen-presenting cells, and are regarded as "natural adjuvants" for the induction of primary T or T-dependent immunity. DCs in the peripheral sites capture and process antigens. Encounter of exogenous or endogenous stimuli mature the function of DCs, and they thus acquire T-cell stimulatory capacity and distinct chemotactic behavior which enables them to migrate to lymphoid tissue. In the secondary lymphoid organs, they present antigens to T- and B-cells and stimulate their proliferation. Dendritic cells are also involved in tolerance induction, in particular, to self antigens. DCs also play a key role in the transmission of many pathogens, and therefore may become targets for designing new therapies. DCs have been manipulated in vitro and in vivo for cancer immunotherapy. In this article, we provide a concise overview of DC biology and its current and future role in clinical settings.en_HK
dc.languageengen_US
dc.publisherHistology and Histopathology. The Journal's web site is located at http://www.hh.um.esen_HK
dc.relation.ispartofHistology and Histopathologyen_HK
dc.subjectSpecies Index: Human Immunodeficiency Virusen_US
dc.subject.meshAnimalsen_HK
dc.subject.meshAntigen Presentationen_HK
dc.subject.meshCell Divisionen_HK
dc.subject.meshCell Movementen_HK
dc.subject.meshDendritic Cells - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmune Toleranceen_HK
dc.subject.meshImmunotherapyen_HK
dc.subject.meshModels, Biologicalen_HK
dc.subject.meshNeoplasms - therapyen_HK
dc.subject.meshT-Lymphocytes - metabolismen_HK
dc.titleDendritic cells: Sentinels against pathogensen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, VSF:sfvchan@hku.hken_HK
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hken_HK
dc.identifier.authorityChan, VSF=rp01459en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid14702200en_HK
dc.identifier.scopuseid_2-s2.0-1642515006en_HK
dc.identifier.hkuros89125-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1642515006&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue1en_HK
dc.identifier.spage317en_HK
dc.identifier.epage324en_HK
dc.identifier.isiWOS:000188355400037-
dc.publisher.placeSpainen_HK
dc.identifier.scopusauthoridChung, NPY=9271796700en_HK
dc.identifier.scopusauthoridChen, Y=16416830300en_HK
dc.identifier.scopusauthoridChan, VSF=35200370000en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK
dc.identifier.scopusauthoridLin, CLS=37099293900en_HK

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