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Article: Non-axial bone fracture but not depression as a risk factor for coeliac disease

TitleNon-axial bone fracture but not depression as a risk factor for coeliac disease
Authors
KeywordsReferences (11) View In Table Layout
Issue Date2010
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IMJ
Citation
Internal Medicine Journal, 2010, v. 40 n. 3, p. 225-227 How to Cite?
AbstractScreening for coeliac disease is confined to subgroups at greater risk for the disease, including type 1 diabetes mellitus, autoimmune thyroid disease and family members of affected individuals. This study examined the hypothesis that patients taking antidepressants or presenting with fractures could represent new subgroups at higher risk for coeliac disease. A total of 105 and 199 consecutive patients presenting to hospital taking antidepressants and/or with a fracture was screened with IgA tissue transglutaminase and had their IgA serum levels quantified. Patients with positive serology were offered further diagnostic and management follow up. No patients taking antidepressants had positive serology. Seven with fractures had elevated titres of IgA tissue transglutaminase. All of these patients had presented with non-axial fractures, representing a prevalence of 5.2% (95% confidence interval: 1.4-8.9%). Uptake of further investigation and management was poor. Patients presenting with non-axial fractures may be a subgroup in whom coeliac screening may be indicated. There needs to be greater awareness of atypical presentations of coeliac disease. © 2010 Royal Australasian College of Physicians.
Persistent Identifierhttp://hdl.handle.net/10722/132479
ISSN
2015 Impact Factor: 1.526
2015 SCImago Journal Rankings: 0.616
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTan, VPen_HK
dc.contributor.authorChing, SLen_HK
dc.contributor.authorAnderson, RPen_HK
dc.contributor.authorGibson, PRen_HK
dc.date.accessioned2011-03-28T09:25:12Z-
dc.date.available2011-03-28T09:25:12Z-
dc.date.issued2010en_HK
dc.identifier.citationInternal Medicine Journal, 2010, v. 40 n. 3, p. 225-227en_HK
dc.identifier.issn1444-0903en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132479-
dc.description.abstractScreening for coeliac disease is confined to subgroups at greater risk for the disease, including type 1 diabetes mellitus, autoimmune thyroid disease and family members of affected individuals. This study examined the hypothesis that patients taking antidepressants or presenting with fractures could represent new subgroups at higher risk for coeliac disease. A total of 105 and 199 consecutive patients presenting to hospital taking antidepressants and/or with a fracture was screened with IgA tissue transglutaminase and had their IgA serum levels quantified. Patients with positive serology were offered further diagnostic and management follow up. No patients taking antidepressants had positive serology. Seven with fractures had elevated titres of IgA tissue transglutaminase. All of these patients had presented with non-axial fractures, representing a prevalence of 5.2% (95% confidence interval: 1.4-8.9%). Uptake of further investigation and management was poor. Patients presenting with non-axial fractures may be a subgroup in whom coeliac screening may be indicated. There needs to be greater awareness of atypical presentations of coeliac disease. © 2010 Royal Australasian College of Physicians.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IMJen_HK
dc.relation.ispartofInternal Medicine Journalen_HK
dc.subjectReferences (11) View In Table Layouten_US
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCeliac Disease - epidemiology - etiology - psychologyen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshDepression - complications - epidemiology - psychologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFractures, Bone - complications - epidemiology - psychologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPilot Projectsen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshYoung Adulten_HK
dc.titleNon-axial bone fracture but not depression as a risk factor for coeliac diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailTan, VP:vpytan@hku.hken_HK
dc.identifier.authorityTan, VP=rp01458en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1445-5994.2009.02153.xen_HK
dc.identifier.pmid20446968-
dc.identifier.scopuseid_2-s2.0-77949616211en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949616211&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue3en_HK
dc.identifier.spage225en_HK
dc.identifier.epage227en_HK
dc.identifier.eissn1445-5994-
dc.identifier.isiWOS:000275638100010-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridTan, VP=24449627600en_HK
dc.identifier.scopusauthoridChing, SL=37012005800en_HK
dc.identifier.scopusauthoridAnderson, RP=35611164900en_HK
dc.identifier.scopusauthoridGibson, PR=16405639800en_HK
dc.identifier.citeulike6885119-

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