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Conference Paper: Chemoprophylaxis in colorectal cancer: Current concepts and a practical algorithm for use

TitleChemoprophylaxis in colorectal cancer: Current concepts and a practical algorithm for use
Authors
Keywords5-ASA
Adenoma
Adenomatous polyps
Calcium
Chemoprevention
Chemoprophylaxis
Colorectal carcinoma
COX-2 inhibitors
NSAIDS
Vitamin D
Issue Date2010
PublisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eid
Citation
The 5th Annual Conference of the Organisation for Oncology and Translational Research, Macau, China, 20-21 February 2009. In Expert Opinion on Investigational Drugs, 2010, v. 19 n. s1, p. S57-S66 How to Cite?
AbstractColorectal cancer (CRC) is the second most common lethal cancer in the Western world. There is a 10 to 20 years lead time from normal mucosa to carcinoma which offers a window of opportunity to modify and prevent the outcome of CRC, with its incipient morbidity and mortality. The objective of this paper is to review the evidence for chemoprophylaxis in CRC, identify currently used agents and determine their role in the current management algorithm of CRC. Large cohort-control and randomised controlled trials in the most studied chemoprophylaxis agents are reviewed. Currently, the role for chemoprophylaxis in CRC remains a niche area, with celecoxib the only recommended agent for use in patients with familial polyposis syndromes. However, the role of chemoprophylaxis is likely to grow significantly in the next decade as understanding of the stepwise tumorigenesis cascade becomes better understood and current clinical trials are completed. © 2010 Informa UK Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/132478
ISSN
2015 Impact Factor: 4.408
2015 SCImago Journal Rankings: 1.314
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTan, VPYen_HK
dc.contributor.authorChan, Pen_HK
dc.contributor.authorHung, IFNen_HK
dc.contributor.authorPang, Ren_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2011-03-28T09:25:12Z-
dc.date.available2011-03-28T09:25:12Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 5th Annual Conference of the Organisation for Oncology and Translational Research, Macau, China, 20-21 February 2009. In Expert Opinion on Investigational Drugs, 2010, v. 19 n. s1, p. S57-S66en_HK
dc.identifier.issn1354-3784en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132478-
dc.description.abstractColorectal cancer (CRC) is the second most common lethal cancer in the Western world. There is a 10 to 20 years lead time from normal mucosa to carcinoma which offers a window of opportunity to modify and prevent the outcome of CRC, with its incipient morbidity and mortality. The objective of this paper is to review the evidence for chemoprophylaxis in CRC, identify currently used agents and determine their role in the current management algorithm of CRC. Large cohort-control and randomised controlled trials in the most studied chemoprophylaxis agents are reviewed. Currently, the role for chemoprophylaxis in CRC remains a niche area, with celecoxib the only recommended agent for use in patients with familial polyposis syndromes. However, the role of chemoprophylaxis is likely to grow significantly in the next decade as understanding of the stepwise tumorigenesis cascade becomes better understood and current clinical trials are completed. © 2010 Informa UK Ltd.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eiden_HK
dc.relation.ispartofExpert Opinion on Investigational Drugsen_HK
dc.rightsExpert Opinion on Investigational Drugs: authoritative analysis of R&D trends. Copyright © Informa Healthcare.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject5-ASAen_HK
dc.subjectAdenomaen_HK
dc.subjectAdenomatous polypsen_HK
dc.subjectCalciumen_HK
dc.subjectChemopreventionen_HK
dc.subjectChemoprophylaxisen_HK
dc.subjectColorectal carcinomaen_HK
dc.subjectCOX-2 inhibitorsen_HK
dc.subjectNSAIDSen_HK
dc.subjectVitamin Den_HK
dc.subject.meshAdenomatous Polyposis Coli - complications - drug therapy-
dc.subject.meshAlgorithms-
dc.subject.meshAnticarcinogenic Agents - pharmacology - therapeutic use-
dc.subject.meshClinical Trials as Topic-
dc.subject.meshColorectal Neoplasms - etiology - prevention and control-
dc.titleChemoprophylaxis in colorectal cancer: Current concepts and a practical algorithm for useen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1354-3784&volume=19&issue=s1&spage=S57&epage=S66&date=2010&atitle=Chemoprophylaxis+in+colorectal+cancer:+current+concepts+and+a+practical+algorithm+for+use-
dc.identifier.emailTan, VPY: vpytan@hku.hken_HK
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hken_HK
dc.identifier.emailPang, R: robertap@hkucc.hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityTan, VPY=rp01458en_HK
dc.identifier.authorityHung, IFN=rp00508en_HK
dc.identifier.authorityPang, R=rp00274en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturepostprinten_US
dc.identifier.doi10.1517/13543781003714923en_HK
dc.identifier.pmid20374032-
dc.identifier.scopuseid_2-s2.0-77950671233en_HK
dc.identifier.hkuros173892-
dc.identifier.hkuros232428-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950671233&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issuesuppl. 1en_HK
dc.identifier.spageS57en_HK
dc.identifier.epageS66en_HK
dc.identifier.eissn1744-7658-
dc.identifier.isiWOS:000276415800009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTan, VPY=24449627600en_HK
dc.identifier.scopusauthoridChan, P=7403497841en_HK
dc.identifier.scopusauthoridHung, IFN=7006103457en_HK
dc.identifier.scopusauthoridPang, R=7004376659en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.customcontrol.immutablesml 160622 amended-

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