File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: A subpopulation of CD26 + cancer stem cells with metastatic capacity in human colorectal cancer
  • Basic View
  • Metadata View
  • XML View
TitleA subpopulation of CD26 + cancer stem cells with metastatic capacity in human colorectal cancer
 
AuthorsPang, R1
Law, WL1
Chu, ACY1
Poon, JT1
Lam, CSC1
Chow, AKM1
Ng, L1
Cheung, LWH1
Lan, XR1
Lan, HY1
Tan, VPY1
Yau, TC1
Poon, RT1
Wong, BCY1
 
KeywordsAntigen Expression
Cancer Combination Chemotherapy
Cancer Stem Cell
Cell Invasion
Colorectal Cancer
 
Issue Date2010
 
PublisherCell Press. The Journal's web site is located at http://www.cellstemcell.com
 
CitationCell Stem Cell, 2010, v. 6 n. 6, p. 603-615 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.stem.2010.04.001
 
AbstractRecent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumor growth in colorectal cancer. However, the role of CSCs in colorectal cancer metastasis is unclear. Here, we identified a subpopulation of CD26 + cells uniformly present in both the primary and metastatic tumors in colorectal cancer patients with liver metastasis. Furthermore, in patients without distant metastasis at the time of presentation, the presence of CD26 + cells in their primary tumors predicted distant metastasis on follow-up. Isolated CD26 + cells, but not CD26 - cells, led to development of distant metastasis when injected into the mouse cecal wall. CD26 + cells were also associated with enhanced invasiveness and chemoresistance. Our findings have uncovered a critical role of CSCs in metastatic progression of cancer. Furthermore, the ability to predict metastasis based on analysis of CSC subsets in the primary tumor may have important clinical implication as a selection criterion for adjuvant therapy. © 2010 Elsevier Inc.
 
ISSN1934-5909
2013 Impact Factor: 22.151
2013 SCImago Journal Rankings: 16.053
 
DOIhttp://dx.doi.org/10.1016/j.stem.2010.04.001
 
ISI Accession Number IDWOS:000278840700020
Funding AgencyGrant Number
Strategic Research Theme of Cancer
Seed Funding Research Grant
University of Hong Kong
Funding Information:

We thank A.M. Cheung for technical assistance in flow cytometry analysis, R. De Maria and X.W. Wang for critical discussion of the manuscript, A. Chan and S.Y. Fan for specimen collection, and G.S.W. Tsao for support. This study is supported by Strategic Research Theme of Cancer, Seed Funding Research Grant, and Donation of the Li Ka Shing Foundation of Matching Grants of The University of Hong Kong.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorPang, R
 
dc.contributor.authorLaw, WL
 
dc.contributor.authorChu, ACY
 
dc.contributor.authorPoon, JT
 
dc.contributor.authorLam, CSC
 
dc.contributor.authorChow, AKM
 
dc.contributor.authorNg, L
 
dc.contributor.authorCheung, LWH
 
dc.contributor.authorLan, XR
 
dc.contributor.authorLan, HY
 
dc.contributor.authorTan, VPY
 
dc.contributor.authorYau, TC
 
dc.contributor.authorPoon, RT
 
dc.contributor.authorWong, BCY
 
dc.date.accessioned2011-03-28T09:25:08Z
 
dc.date.available2011-03-28T09:25:08Z
 
dc.date.issued2010
 
dc.description.abstractRecent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumor growth in colorectal cancer. However, the role of CSCs in colorectal cancer metastasis is unclear. Here, we identified a subpopulation of CD26 + cells uniformly present in both the primary and metastatic tumors in colorectal cancer patients with liver metastasis. Furthermore, in patients without distant metastasis at the time of presentation, the presence of CD26 + cells in their primary tumors predicted distant metastasis on follow-up. Isolated CD26 + cells, but not CD26 - cells, led to development of distant metastasis when injected into the mouse cecal wall. CD26 + cells were also associated with enhanced invasiveness and chemoresistance. Our findings have uncovered a critical role of CSCs in metastatic progression of cancer. Furthermore, the ability to predict metastasis based on analysis of CSC subsets in the primary tumor may have important clinical implication as a selection criterion for adjuvant therapy. © 2010 Elsevier Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationCell Stem Cell, 2010, v. 6 n. 6, p. 603-615 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.stem.2010.04.001
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.stem.2010.04.001
 
dc.identifier.epage615
 
dc.identifier.hkuros173427
 
dc.identifier.isiWOS:000278840700020
Funding AgencyGrant Number
Strategic Research Theme of Cancer
Seed Funding Research Grant
University of Hong Kong
Funding Information:

We thank A.M. Cheung for technical assistance in flow cytometry analysis, R. De Maria and X.W. Wang for critical discussion of the manuscript, A. Chan and S.Y. Fan for specimen collection, and G.S.W. Tsao for support. This study is supported by Strategic Research Theme of Cancer, Seed Funding Research Grant, and Donation of the Li Ka Shing Foundation of Matching Grants of The University of Hong Kong.

 
dc.identifier.issn1934-5909
2013 Impact Factor: 22.151
2013 SCImago Journal Rankings: 16.053
 
dc.identifier.issue6
 
dc.identifier.openurl
 
dc.identifier.pmid20569697
 
dc.identifier.scopuseid_2-s2.0-77956641496
 
dc.identifier.spage603
 
dc.identifier.urihttp://hdl.handle.net/10722/132475
 
dc.identifier.volume6
 
dc.languageeng
 
dc.publisherCell Press. The Journal's web site is located at http://www.cellstemcell.com
 
dc.publisher.placeUnited States
 
dc.relation.ispartofCell Stem Cell
 
dc.relation.referencesReferences in Scopus
 
dc.subjectAntigen Expression
 
dc.subjectCancer Combination Chemotherapy
 
dc.subjectCancer Stem Cell
 
dc.subjectCell Invasion
 
dc.subjectColorectal Cancer
 
dc.titleA subpopulation of CD26 + cancer stem cells with metastatic capacity in human colorectal cancer
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Pang, R</contributor.author>
<contributor.author>Law, WL</contributor.author>
<contributor.author>Chu, ACY</contributor.author>
<contributor.author>Poon, JT</contributor.author>
<contributor.author>Lam, CSC</contributor.author>
<contributor.author>Chow, AKM</contributor.author>
<contributor.author>Ng, L</contributor.author>
<contributor.author>Cheung, LWH</contributor.author>
<contributor.author>Lan, XR</contributor.author>
<contributor.author>Lan, HY</contributor.author>
<contributor.author>Tan, VPY</contributor.author>
<contributor.author>Yau, TC</contributor.author>
<contributor.author>Poon, RT</contributor.author>
<contributor.author>Wong, BCY</contributor.author>
<date.accessioned>2011-03-28T09:25:08Z</date.accessioned>
<date.available>2011-03-28T09:25:08Z</date.available>
<date.issued>2010</date.issued>
<identifier.citation>Cell Stem Cell, 2010, v. 6 n. 6, p. 603-615</identifier.citation>
<identifier.issn>1934-5909</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/132475</identifier.uri>
<description.abstract>Recent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumor growth in colorectal cancer. However, the role of CSCs in colorectal cancer metastasis is unclear. Here, we identified a subpopulation of CD26 + cells uniformly present in both the primary and metastatic tumors in colorectal cancer patients with liver metastasis. Furthermore, in patients without distant metastasis at the time of presentation, the presence of CD26 + cells in their primary tumors predicted distant metastasis on follow-up. Isolated CD26 + cells, but not CD26 - cells, led to development of distant metastasis when injected into the mouse cecal wall. CD26 + cells were also associated with enhanced invasiveness and chemoresistance. Our findings have uncovered a critical role of CSCs in metastatic progression of cancer. Furthermore, the ability to predict metastasis based on analysis of CSC subsets in the primary tumor may have important clinical implication as a selection criterion for adjuvant therapy. &#169; 2010 Elsevier Inc.</description.abstract>
<language>eng</language>
<publisher>Cell Press. The Journal&apos;s web site is located at http://www.cellstemcell.com</publisher>
<relation.ispartof>Cell Stem Cell</relation.ispartof>
<subject>Antigen Expression</subject>
<subject>Cancer Combination Chemotherapy</subject>
<subject>Cancer Stem Cell</subject>
<subject>Cell Invasion</subject>
<subject>Colorectal Cancer</subject>
<title>A subpopulation of CD26 + cancer stem cells with metastatic capacity in human colorectal cancer</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=1934-5909&amp;volume=6&amp;issue=6&amp;spage=603&amp;epage=615&amp;date=2010&amp;atitle=A+subpopulation+of+CD26++cancer+stem+cells+with+metastatic+capacity+in+human+colorectal+cancer</identifier.openurl>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1016/j.stem.2010.04.001</identifier.doi>
<identifier.pmid>20569697</identifier.pmid>
<identifier.scopus>eid_2-s2.0-77956641496</identifier.scopus>
<identifier.hkuros>173427</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-77956641496&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>6</identifier.volume>
<identifier.issue>6</identifier.issue>
<identifier.spage>603</identifier.spage>
<identifier.epage>615</identifier.epage>
<identifier.isi>WOS:000278840700020</identifier.isi>
<publisher.place>United States</publisher.place>
</item>
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine