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Article: Cost-effectiveness analysis of influenza and pneumococcal vaccination for Hong Kong elderly in long-term care facilities

TitleCost-effectiveness analysis of influenza and pneumococcal vaccination for Hong Kong elderly in long-term care facilities
Authors
KeywordsAged
Article
Controlled Study
Cost Benefit Analysis
Cost Effectiveness Analysis
Female
Health Care Cost
Health Care Facility
Hong Kong
Human
Influenza
Influenza Vaccination
Long Term Care
Major Clinical Study
Male
Pneumococcal Infection
Quality Adjusted Life Year
Unspecified Side Effect
Issue Date2009
PublisherBMJ Publishing Group. The Journal's web site is located at http://jech.bmjjournals.com/
Citation
Journal Of Epidemiology And Community Health, 2009, v. 63 n. 11, p. 906-911 How to Cite?
AbstractBackground: To compare cost and quality-adjusted life-years (QALYs) gained by influenza vaccination with or without pneumococcal vaccination in the elderly living in long-term care facilities (LTCFs). Methods: Cost-effectiveness analysis based on Markov modelling over 5 years, from a Hong Kong public health provider's perspective, on a hypothetical cohort of LTCF residents aged ≥65 years. Benefit-cost ratio (BCR) and net present value (NPV) of two vaccination strategies versus no vaccination were estimated. The cost and QALYs gained by two vaccination strategies were compared by Student's t-test in probabilistic sensitivity analysis (10 000 Monte Carlo simulations). Results: Both vaccination strategies had high BCRs and NPVs (6.39 and US$334 for influenza vaccination; 5.10 and US$332 for influenza plus pneumococcal vaccination). In base case analysis, the two vaccination strategies were expected to cost less and gain higher QALYs than no vaccination. In probabilistic sensitivity analysis, the cost of combined vaccination and influenza vaccination was significantly lower (p<0.001) than the cost of no vaccination. Both vaccination strategies gained significantly higher (p<0.001) QALYs than no vaccination. The QALYs gained by combined vaccination were significantly higher (p=0.030) than those gained by influenza vaccination alone. The total cost of combined vaccination was significantly lower (p=0.011) than that of influenza vaccination. Conclusion: Influenza vaccination with or without pneumococcal vaccination appears to be less costly with higher QALYs gained than no vaccination, over a 5-year period, for elderly people living in LTCFs from the perspective of a Hong Kong public health organisation. Combined vaccination was more likely to gain higher QALYs with lower total cost than influenza vaccination alone.
Persistent Identifierhttp://hdl.handle.net/10722/132416
ISSN
2015 Impact Factor: 3.865
2015 SCImago Journal Rankings: 1.890
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYou, JHSen_HK
dc.contributor.authorWong, WCWen_HK
dc.contributor.authorIp, Men_HK
dc.contributor.authorLee, NLSen_HK
dc.contributor.authorHo, SCen_HK
dc.date.accessioned2011-03-28T09:24:25Z-
dc.date.available2011-03-28T09:24:25Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Epidemiology And Community Health, 2009, v. 63 n. 11, p. 906-911en_HK
dc.identifier.issn0143-005Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/132416-
dc.description.abstractBackground: To compare cost and quality-adjusted life-years (QALYs) gained by influenza vaccination with or without pneumococcal vaccination in the elderly living in long-term care facilities (LTCFs). Methods: Cost-effectiveness analysis based on Markov modelling over 5 years, from a Hong Kong public health provider's perspective, on a hypothetical cohort of LTCF residents aged ≥65 years. Benefit-cost ratio (BCR) and net present value (NPV) of two vaccination strategies versus no vaccination were estimated. The cost and QALYs gained by two vaccination strategies were compared by Student's t-test in probabilistic sensitivity analysis (10 000 Monte Carlo simulations). Results: Both vaccination strategies had high BCRs and NPVs (6.39 and US$334 for influenza vaccination; 5.10 and US$332 for influenza plus pneumococcal vaccination). In base case analysis, the two vaccination strategies were expected to cost less and gain higher QALYs than no vaccination. In probabilistic sensitivity analysis, the cost of combined vaccination and influenza vaccination was significantly lower (p<0.001) than the cost of no vaccination. Both vaccination strategies gained significantly higher (p<0.001) QALYs than no vaccination. The QALYs gained by combined vaccination were significantly higher (p=0.030) than those gained by influenza vaccination alone. The total cost of combined vaccination was significantly lower (p=0.011) than that of influenza vaccination. Conclusion: Influenza vaccination with or without pneumococcal vaccination appears to be less costly with higher QALYs gained than no vaccination, over a 5-year period, for elderly people living in LTCFs from the perspective of a Hong Kong public health organisation. Combined vaccination was more likely to gain higher QALYs with lower total cost than influenza vaccination alone.en_HK
dc.languageengen_US
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://jech.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Epidemiology and Community Healthen_HK
dc.subjectAgeden_US
dc.subjectArticleen_US
dc.subjectControlled Studyen_US
dc.subjectCost Benefit Analysisen_US
dc.subjectCost Effectiveness Analysisen_US
dc.subjectFemaleen_US
dc.subjectHealth Care Costen_US
dc.subjectHealth Care Facilityen_US
dc.subjectHong Kongen_US
dc.subjectHumanen_US
dc.subjectInfluenzaen_US
dc.subjectInfluenza Vaccinationen_US
dc.subjectLong Term Careen_US
dc.subjectMajor Clinical Studyen_US
dc.subjectMaleen_US
dc.subjectPneumococcal Infectionen_US
dc.subjectQuality Adjusted Life Yearen_US
dc.subjectUnspecified Side Effecten_US
dc.titleCost-effectiveness analysis of influenza and pneumococcal vaccination for Hong Kong elderly in long-term care facilitiesen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, WCW:wongwcw@hku.hken_HK
dc.identifier.authorityWong, WCW=rp01457en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1136/jech.2008.081885en_HK
dc.identifier.pmid19608558-
dc.identifier.scopuseid_2-s2.0-70350230262en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350230262&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume63en_HK
dc.identifier.issue11en_HK
dc.identifier.spage906en_HK
dc.identifier.epage911en_HK
dc.identifier.eissn1470-2738-
dc.identifier.isiWOS:000270726800010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYou, JHS=7201683649en_HK
dc.identifier.scopusauthoridWong, WCW=25230779000en_HK
dc.identifier.scopusauthoridIp, M=7102423261en_HK
dc.identifier.scopusauthoridLee, NLS=7402722286en_HK
dc.identifier.scopusauthoridHo, SC=7403716908en_HK

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