File Download
  • No File Attached
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Alterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress
  • Basic View
  • Metadata View
  • XML View
TitleAlterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress
 
AuthorsYue, KKM1
Leung, SN1
Man, PM1
Yeung, WF1
Chung, WS1
Lee, KW1
Leung, AWN1
Cheng, CHK2
 
Issue Date2005
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
 
CitationLife Sciences, 2005, v. 77 n. 7, p. 721-734 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.lfs.2004.10.081
 
AbstractProfound changes in antioxidant enzyme activities were observed in a number of vascular tissues during the development of streptozotocin-induced diabetes in rats. In the eyes, there was an increase in superoxide dismutase activity at week 4 of diabetes. However, no difference in superoxide dismutase activity was observed between the control and diabetic animals at week 8. On the other hand, the diabetic state did not seem to affect the catalase activity in the eyes. There was a generalized increase in catalase activity of the eyes from week 4 to week 8 irrespective of the diabetic state. For glutathione peroxidase in the eyes, a decreased activity was observed in the diabetic animals at week 8, but not in week 4. A different pattern of enzyme activity changes was observed in the aorta where an increase in superoxide dismutase activity was observed in the diabetic group at week 4 but not in week 8. On the other hand, an increase in catalase activity was observed only at week 8 but not at week 4. Whereas there was no observed difference between the control and diabetic animals in glutathione peroxidase activity in the aorta, except for a generalized decrease from week 4 to week 8 in both groups of animals. In big contrast to the eyes and aorta where an increase in superoxide dismutase activity was observed at week 4 of diabetes, no change in kidney superoxide dismutase activity was noted at week 4 and a decrease was observed at week 8. A similar pattern of enzyme activity changes was observed for glutathione peroxidase in the kidneys. The catalase activity in the kidneys was not affected at all by the diabetic state at both week 4 and week 8. These results clearly demonstrate the active involvement of these antioxidant enzymes during the development of diabetes, and could be rationalized by the differential response of the tissues towards the different extent of oxidative stress imposed by the diabetic state on the different tissues.
 
ISSN0024-3205
2013 Impact Factor: 2.296
2013 SCImago Journal Rankings: 0.962
 
DOIhttp://dx.doi.org/10.1016/j.lfs.2004.10.081
 
ISI Accession Number IDWOS:000229885100001
 
DC FieldValue
dc.contributor.authorYue, KKM
 
dc.contributor.authorLeung, SN
 
dc.contributor.authorMan, PM
 
dc.contributor.authorYeung, WF
 
dc.contributor.authorChung, WS
 
dc.contributor.authorLee, KW
 
dc.contributor.authorLeung, AWN
 
dc.contributor.authorCheng, CHK
 
dc.date.accessioned2011-03-21T08:59:48Z
 
dc.date.available2011-03-21T08:59:48Z
 
dc.date.issued2005
 
dc.description.abstractProfound changes in antioxidant enzyme activities were observed in a number of vascular tissues during the development of streptozotocin-induced diabetes in rats. In the eyes, there was an increase in superoxide dismutase activity at week 4 of diabetes. However, no difference in superoxide dismutase activity was observed between the control and diabetic animals at week 8. On the other hand, the diabetic state did not seem to affect the catalase activity in the eyes. There was a generalized increase in catalase activity of the eyes from week 4 to week 8 irrespective of the diabetic state. For glutathione peroxidase in the eyes, a decreased activity was observed in the diabetic animals at week 8, but not in week 4. A different pattern of enzyme activity changes was observed in the aorta where an increase in superoxide dismutase activity was observed in the diabetic group at week 4 but not in week 8. On the other hand, an increase in catalase activity was observed only at week 8 but not at week 4. Whereas there was no observed difference between the control and diabetic animals in glutathione peroxidase activity in the aorta, except for a generalized decrease from week 4 to week 8 in both groups of animals. In big contrast to the eyes and aorta where an increase in superoxide dismutase activity was observed at week 4 of diabetes, no change in kidney superoxide dismutase activity was noted at week 4 and a decrease was observed at week 8. A similar pattern of enzyme activity changes was observed for glutathione peroxidase in the kidneys. The catalase activity in the kidneys was not affected at all by the diabetic state at both week 4 and week 8. These results clearly demonstrate the active involvement of these antioxidant enzymes during the development of diabetes, and could be rationalized by the differential response of the tissues towards the different extent of oxidative stress imposed by the diabetic state on the different tissues.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationLife Sciences, 2005, v. 77 n. 7, p. 721-734 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.lfs.2004.10.081
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.lfs.2004.10.081
 
dc.identifier.epage734
 
dc.identifier.hkuros176795
 
dc.identifier.isiWOS:000229885100001
 
dc.identifier.issn0024-3205
2013 Impact Factor: 2.296
2013 SCImago Journal Rankings: 0.962
 
dc.identifier.issue7
 
dc.identifier.openurl
 
dc.identifier.pmid15936347
 
dc.identifier.scopuseid_2-s2.0-20344372393
 
dc.identifier.spage721
 
dc.identifier.urihttp://hdl.handle.net/10722/132185
 
dc.identifier.volume77
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
 
dc.relation.ispartofLife Sciences
 
dc.subject.meshAorta - metabolism
 
dc.subject.meshDiabetes Mellitus, Experimental - enzymology - physiopathology
 
dc.subject.meshEye - metabolism
 
dc.subject.meshKidney - metabolism
 
dc.subject.meshOxidative Stress - physiology
 
dc.titleAlterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Yue, KKM</contributor.author>
<contributor.author>Leung, SN</contributor.author>
<contributor.author>Man, PM</contributor.author>
<contributor.author>Yeung, WF</contributor.author>
<contributor.author>Chung, WS</contributor.author>
<contributor.author>Lee, KW</contributor.author>
<contributor.author>Leung, AWN</contributor.author>
<contributor.author>Cheng, CHK</contributor.author>
<date.accessioned>2011-03-21T08:59:48Z</date.accessioned>
<date.available>2011-03-21T08:59:48Z</date.available>
<date.issued>2005</date.issued>
<identifier.citation>Life Sciences, 2005, v. 77 n. 7, p. 721-734</identifier.citation>
<identifier.issn>0024-3205</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/132185</identifier.uri>
<description.abstract>Profound changes in antioxidant enzyme activities were observed in a number of vascular tissues during the development of streptozotocin-induced diabetes in rats. In the eyes, there was an increase in superoxide dismutase activity at week 4 of diabetes. However, no difference in superoxide dismutase activity was observed between the control and diabetic animals at week 8. On the other hand, the diabetic state did not seem to affect the catalase activity in the eyes. There was a generalized increase in catalase activity of the eyes from week 4 to week 8 irrespective of the diabetic state. For glutathione peroxidase in the eyes, a decreased activity was observed in the diabetic animals at week 8, but not in week 4. A different pattern of enzyme activity changes was observed in the aorta where an increase in superoxide dismutase activity was observed in the diabetic group at week 4 but not in week 8. On the other hand, an increase in catalase activity was observed only at week 8 but not at week 4. Whereas there was no observed difference between the control and diabetic animals in glutathione peroxidase activity in the aorta, except for a generalized decrease from week 4 to week 8 in both groups of animals. In big contrast to the eyes and aorta where an increase in superoxide dismutase activity was observed at week 4 of diabetes, no change in kidney superoxide dismutase activity was noted at week 4 and a decrease was observed at week 8. A similar pattern of enzyme activity changes was observed for glutathione peroxidase in the kidneys. The catalase activity in the kidneys was not affected at all by the diabetic state at both week 4 and week 8. These results clearly demonstrate the active involvement of these antioxidant enzymes during the development of diabetes, and could be rationalized by the differential response of the tissues towards the different extent of oxidative stress imposed by the diabetic state on the different tissues.</description.abstract>
<language>eng</language>
<publisher>Elsevier Inc. The Journal&apos;s web site is located at http://www.elsevier.com/locate/lifescie</publisher>
<relation.ispartof>Life Sciences</relation.ispartof>
<subject.mesh>Aorta - metabolism</subject.mesh>
<subject.mesh>Diabetes Mellitus, Experimental - enzymology - physiopathology</subject.mesh>
<subject.mesh>Eye - metabolism</subject.mesh>
<subject.mesh>Kidney - metabolism</subject.mesh>
<subject.mesh>Oxidative Stress - physiology</subject.mesh>
<title>Alterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0024-3205&amp;volume=77&amp;issue=7&amp;spage=721&amp;epage=734&amp;date=2005&amp;atitle=Alterations+in+antioxidant+enzyme+activities+in+the+eyes,+aorta+and+kidneys+of+diabetic+rats+relevant+to+the+onset+of+oxidative+stress</identifier.openurl>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1016/j.lfs.2004.10.081</identifier.doi>
<identifier.pmid>15936347</identifier.pmid>
<identifier.scopus>eid_2-s2.0-20344372393</identifier.scopus>
<identifier.hkuros>176795</identifier.hkuros>
<identifier.volume>77</identifier.volume>
<identifier.issue>7</identifier.issue>
<identifier.spage>721</identifier.spage>
<identifier.epage>734</identifier.epage>
<identifier.isi>WOS:000229885100001</identifier.isi>
</item>
Author Affiliations
  1. Hong Kong Baptist University
  2. Chinese University of Hong Kong