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Article: Alterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress

TitleAlterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress
Authors
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2005, v. 77 n. 7, p. 721-734 How to Cite?
AbstractProfound changes in antioxidant enzyme activities were observed in a number of vascular tissues during the development of streptozotocin-induced diabetes in rats. In the eyes, there was an increase in superoxide dismutase activity at week 4 of diabetes. However, no difference in superoxide dismutase activity was observed between the control and diabetic animals at week 8. On the other hand, the diabetic state did not seem to affect the catalase activity in the eyes. There was a generalized increase in catalase activity of the eyes from week 4 to week 8 irrespective of the diabetic state. For glutathione peroxidase in the eyes, a decreased activity was observed in the diabetic animals at week 8, but not in week 4. A different pattern of enzyme activity changes was observed in the aorta where an increase in superoxide dismutase activity was observed in the diabetic group at week 4 but not in week 8. On the other hand, an increase in catalase activity was observed only at week 8 but not at week 4. Whereas there was no observed difference between the control and diabetic animals in glutathione peroxidase activity in the aorta, except for a generalized decrease from week 4 to week 8 in both groups of animals. In big contrast to the eyes and aorta where an increase in superoxide dismutase activity was observed at week 4 of diabetes, no change in kidney superoxide dismutase activity was noted at week 4 and a decrease was observed at week 8. A similar pattern of enzyme activity changes was observed for glutathione peroxidase in the kidneys. The catalase activity in the kidneys was not affected at all by the diabetic state at both week 4 and week 8. These results clearly demonstrate the active involvement of these antioxidant enzymes during the development of diabetes, and could be rationalized by the differential response of the tissues towards the different extent of oxidative stress imposed by the diabetic state on the different tissues.
Persistent Identifierhttp://hdl.handle.net/10722/132185
ISSN
2014 Impact Factor: 2.702
2014 SCImago Journal Rankings: 0.921
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYue, KKMen_US
dc.contributor.authorLeung, SNen_US
dc.contributor.authorMan, PMen_US
dc.contributor.authorYeung, WFen_US
dc.contributor.authorChung, WSen_US
dc.contributor.authorLee, KWen_US
dc.contributor.authorLeung, AWNen_US
dc.contributor.authorCheng, CHKen_US
dc.date.accessioned2011-03-21T08:59:48Z-
dc.date.available2011-03-21T08:59:48Z-
dc.date.issued2005en_US
dc.identifier.citationLife Sciences, 2005, v. 77 n. 7, p. 721-734en_US
dc.identifier.issn0024-3205-
dc.identifier.urihttp://hdl.handle.net/10722/132185-
dc.description.abstractProfound changes in antioxidant enzyme activities were observed in a number of vascular tissues during the development of streptozotocin-induced diabetes in rats. In the eyes, there was an increase in superoxide dismutase activity at week 4 of diabetes. However, no difference in superoxide dismutase activity was observed between the control and diabetic animals at week 8. On the other hand, the diabetic state did not seem to affect the catalase activity in the eyes. There was a generalized increase in catalase activity of the eyes from week 4 to week 8 irrespective of the diabetic state. For glutathione peroxidase in the eyes, a decreased activity was observed in the diabetic animals at week 8, but not in week 4. A different pattern of enzyme activity changes was observed in the aorta where an increase in superoxide dismutase activity was observed in the diabetic group at week 4 but not in week 8. On the other hand, an increase in catalase activity was observed only at week 8 but not at week 4. Whereas there was no observed difference between the control and diabetic animals in glutathione peroxidase activity in the aorta, except for a generalized decrease from week 4 to week 8 in both groups of animals. In big contrast to the eyes and aorta where an increase in superoxide dismutase activity was observed at week 4 of diabetes, no change in kidney superoxide dismutase activity was noted at week 4 and a decrease was observed at week 8. A similar pattern of enzyme activity changes was observed for glutathione peroxidase in the kidneys. The catalase activity in the kidneys was not affected at all by the diabetic state at both week 4 and week 8. These results clearly demonstrate the active involvement of these antioxidant enzymes during the development of diabetes, and could be rationalized by the differential response of the tissues towards the different extent of oxidative stress imposed by the diabetic state on the different tissues.-
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie-
dc.relation.ispartofLife Sciencesen_US
dc.subject.meshAorta - metabolism-
dc.subject.meshDiabetes Mellitus, Experimental - enzymology - physiopathology-
dc.subject.meshEye - metabolism-
dc.subject.meshKidney - metabolism-
dc.subject.meshOxidative Stress - physiology-
dc.titleAlterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stressen_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=77&issue=7&spage=721&epage=734&date=2005&atitle=Alterations+in+antioxidant+enzyme+activities+in+the+eyes,+aorta+and+kidneys+of+diabetic+rats+relevant+to+the+onset+of+oxidative+stress-
dc.identifier.emailYeung, WF: jerryno34@yahoo.com.hken_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.lfs.2004.10.081-
dc.identifier.pmid15936347-
dc.identifier.scopuseid_2-s2.0-20344372393-
dc.identifier.hkuros176795en_US
dc.identifier.volume77en_US
dc.identifier.issue7en_US
dc.identifier.spage721en_US
dc.identifier.epage734en_US
dc.identifier.isiWOS:000229885100001-

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