Article: Alterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress

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Publisher Website: 10.1016/j.lfs.2004.10.081
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PMID: 15936347
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Title	Alterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress
Authors	Yue, KKM1 Leung, SN1 Man, PM1 Yeung, WF1 Chung, WS1 Lee, KW1 Leung, AWN1 Cheng, CHK2
Issue Date	2005
Publisher	Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation	Life Sciences, 2005, v. 77 n. 7, p. 721-734 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.lfs.2004.10.081
Abstract	Profound changes in antioxidant enzyme activities were observed in a number of vascular tissues during the development of streptozotocin-induced diabetes in rats. In the eyes, there was an increase in superoxide dismutase activity at week 4 of diabetes. However, no difference in superoxide dismutase activity was observed between the control and diabetic animals at week 8. On the other hand, the diabetic state did not seem to affect the catalase activity in the eyes. There was a generalized increase in catalase activity of the eyes from week 4 to week 8 irrespective of the diabetic state. For glutathione peroxidase in the eyes, a decreased activity was observed in the diabetic animals at week 8, but not in week 4. A different pattern of enzyme activity changes was observed in the aorta where an increase in superoxide dismutase activity was observed in the diabetic group at week 4 but not in week 8. On the other hand, an increase in catalase activity was observed only at week 8 but not at week 4. Whereas there was no observed difference between the control and diabetic animals in glutathione peroxidase activity in the aorta, except for a generalized decrease from week 4 to week 8 in both groups of animals. In big contrast to the eyes and aorta where an increase in superoxide dismutase activity was observed at week 4 of diabetes, no change in kidney superoxide dismutase activity was noted at week 4 and a decrease was observed at week 8. A similar pattern of enzyme activity changes was observed for glutathione peroxidase in the kidneys. The catalase activity in the kidneys was not affected at all by the diabetic state at both week 4 and week 8. These results clearly demonstrate the active involvement of these antioxidant enzymes during the development of diabetes, and could be rationalized by the differential response of the tissues towards the different extent of oxidative stress imposed by the diabetic state on the different tissues.
ISSN	0024-3205 2011 Impact Factor: 2.527 2011 SCImago Journal Rankings: 0.189
DOI	http://dx.doi.org/10.1016/j.lfs.2004.10.081
ISI Accession Number ID	WOS:000229885100001

DC Field	Value
dc.contributor.author	Yue, KKM
dc.contributor.author	Leung, SN
dc.contributor.author	Man, PM
dc.contributor.author	Yeung, WF
dc.contributor.author	Chung, WS
dc.contributor.author	Lee, KW
dc.contributor.author	Leung, AWN
dc.contributor.author	Cheng, CHK
dc.date.accessioned	2011-03-21T08:59:48Z
dc.date.available	2011-03-21T08:59:48Z
dc.date.issued	2005
dc.description.abstract	Profound changes in antioxidant enzyme activities were observed in a number of vascular tissues during the development of streptozotocin-induced diabetes in rats. In the eyes, there was an increase in superoxide dismutase activity at week 4 of diabetes. However, no difference in superoxide dismutase activity was observed between the control and diabetic animals at week 8. On the other hand, the diabetic state did not seem to affect the catalase activity in the eyes. There was a generalized increase in catalase activity of the eyes from week 4 to week 8 irrespective of the diabetic state. For glutathione peroxidase in the eyes, a decreased activity was observed in the diabetic animals at week 8, but not in week 4. A different pattern of enzyme activity changes was observed in the aorta where an increase in superoxide dismutase activity was observed in the diabetic group at week 4 but not in week 8. On the other hand, an increase in catalase activity was observed only at week 8 but not at week 4. Whereas there was no observed difference between the control and diabetic animals in glutathione peroxidase activity in the aorta, except for a generalized decrease from week 4 to week 8 in both groups of animals. In big contrast to the eyes and aorta where an increase in superoxide dismutase activity was observed at week 4 of diabetes, no change in kidney superoxide dismutase activity was noted at week 4 and a decrease was observed at week 8. A similar pattern of enzyme activity changes was observed for glutathione peroxidase in the kidneys. The catalase activity in the kidneys was not affected at all by the diabetic state at both week 4 and week 8. These results clearly demonstrate the active involvement of these antioxidant enzymes during the development of diabetes, and could be rationalized by the differential response of the tissues towards the different extent of oxidative stress imposed by the diabetic state on the different tissues.
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	Life Sciences, 2005, v. 77 n. 7, p. 721-734 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.lfs.2004.10.081
dc.identifier.doi	http://dx.doi.org/10.1016/j.lfs.2004.10.081
dc.identifier.epage	734
dc.identifier.hkuros	176795
dc.identifier.isi	WOS:000229885100001
dc.identifier.issn	0024-3205 2011 Impact Factor: 2.527 2011 SCImago Journal Rankings: 0.189
dc.identifier.issue	7
dc.identifier.openurl
dc.identifier.pmid	15936347
dc.identifier.scopus	eid_2-s2.0-20344372393
dc.identifier.spage	721
dc.identifier.uri	http://hdl.handle.net/10722/132185
dc.identifier.volume	77
dc.language	eng
dc.publisher	Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
dc.relation.ispartof	Life Sciences
dc.subject.mesh	Aorta - metabolism
dc.subject.mesh	Diabetes Mellitus, Experimental - enzymology - physiopathology
dc.subject.mesh	Eye - metabolism
dc.subject.mesh	Kidney - metabolism
dc.subject.mesh	Oxidative Stress - physiology
dc.title	Alterations in antioxidant enzyme activities in the eyes, aorta and kidneys of diabetic rats relevant to the onset of oxidative stress
dc.type	Article

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Author Affiliations

Hong Kong Baptist University
Chinese University of Hong Kong