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Article: COGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal cancer

TitleCOGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal cancer
Authors
KeywordsAssociation
Colorectal cancer
Polymorphism
Issue Date2010
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
Citation
British Journal Of Cancer, 2010, v. 102 n. 2, p. 447-454 How to Cite?
Abstract
It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT. © 2010 Cancer Research UK. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/132166
ISSN
2013 Impact Factor: 4.817
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Cancer Research UK
European Union
Instituto de Salud Carlos IIIFIS 05/1006
08/1359
08/1635
European CommissionFP6 Food-CT-2006-036224
Genome Canada
National Cancer Institute of Canada
Ontario Institute for Cancer Research
Academy of Finland20062011
Sigrid Juselius Foundation
Finnish Cancer Societies
German Genome Network
GACR310/07/1430
Swedish Cancer Foundation
Swedish Research Council
Fondo de Investigacion SanitariaFIS 04/1126
05/2031
05/0071
08/0025
08/1276
03-0070
Xunta de GaliciaPGIDIT07PXIB9101209PR
Fundacion de Investigacion Medica Mutua Madrilena
Ministerio de Educacion y CienciaSAF 07-64873
Asociacion Espanola contra el Cancer
Fundacion Olga Torres
Instituto de Salud Carlos III
NHMRC489418
Ministry of Education, Culture, Sports, Sciences and Technology of the Japanese government
Funding Information:

The work of UK groups is supported by grants from Cancer Research UK and the European Union. In Spain, work is supported by grants from the Instituto de Salud Carlos III, grants FIS 05/1006, 08/1359, 08/1635 and European Commission FP6 Food-CT-2006-036224 (VM). In Canada, work is supported by grants from Genome Canada (the ARCTIC Project), the National Cancer Institute of Canada (the CaRE Project) and the Ontario Institute for Cancer Research. In Finland, work is supported by grants from Academy of Finland (Finnish Centre of Excellence Program 20062011), the Sigrid Juselius Foundation, the Finnish Cancer Societies and by the European Union. The work of DFKS is supported by the German Genome Network (NGFNplus). In the Czech Republic, work is supported by GACR 310/07/1430. In Sweden, work is supported by grants from the Swedish Cancer Foundation and the Swedish Research Council. In Barcelona and Santiago (Epicolon), work is supported by grants from Fondo de Investigacion Sanitaria (FIS 04/1126, 05/2031, 05/0071, 08/0025, 08/1276), Xunta de Galicia (PGIDIT07PXIB9101209PR), Fundacion de Investigacion Medica Mutua Madrilena (CRP and SCB), Ministerio de Educacion y Ciencia (SAF 07-64873), Asociacion Espanola contra el Cancer, Fundacion Olga Torres (SCB) and Accion Transversal contra el Cancer (Instituto de Salud Carlos III). CIBERER and CIBEREHD are funded by the Instituto de Salud Carlos III. SCB is supported by a contract from the Fondo de Investigacion Sanitaria (CP 03-0070, Ministerio de Sanidad. Provision of genotyping is gratefully provided by Santiago de Compostela node of the Spanish National Genotyping Center (CeGen). In The Netherlands, work of RH is supported by the Dutch Cancer Society and the European Community, and the work of JTW, TvW, HM and PD is supported by the Dutch Cancer Society (UL2005-3247) and Fonds NutsOhra. In Hong Kong, work is supported by grants from the Michael and Betty Kadoorie Cancer Genetics Research Programme II and by the Bobby Moore Fund of Cancer Research UK. Work in Australia is conducted under the auspices of the Hilton Ludwig Cancer Metastasis Initiative and supported by a grant from the NHMRC (Project Grant 489418). In Japan, this work was conducted as a part of the BioBank Japan Project that was supported by the Ministry of Education, Culture, Sports, Sciences and Technology of the Japanese government. The ESTHER and VERDI studies are supported by grants from the Baden Wurttemberg Ministry of Research, Science and Arts and the German Cancer Aid (Deutsche Krebshilfe, Grant M24/95/BR I). The Kiel cohort (POPGEN) is funded through the German Ministry of Education and Reserach through the POPGEN Biobank grant and the Colon Cancer Network of the German National Genome Research Network. SHIP is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research, the Ministry of Cultural Affairs, as well as by the Social Ministry of the Federal State of Mecklenburg-West Pomerania. Genome-wide data have been supported by the Federal Ministry of Education and Research (Grant no. 03ZIK012) and by a joint grant from Siemens Healthcare, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania. The University of Greifswald is a member of the 'Center of Knowledge Interchange' program of Siemens AG. MME, AV and LC-C have received funding from Cancer Research UK and Universidad del Tolima.

References

 

DC FieldValueLanguage
dc.contributor.authorTomlinson, IPMen_HK
dc.contributor.authorDunlop, Men_HK
dc.contributor.authorCampbell, Hen_HK
dc.contributor.authorZanke, Ben_HK
dc.contributor.authorGallinger, Sen_HK
dc.contributor.authorHudson, Ten_HK
dc.contributor.authorKoessler, Ten_HK
dc.contributor.authorPharoah, PDen_HK
dc.contributor.authorNiittymäkix, Ien_HK
dc.contributor.authorTuupanenx, Sen_HK
dc.contributor.authorAaltonen, LAen_HK
dc.contributor.authorHemminki, Ken_HK
dc.contributor.authorLindblom, Aen_HK
dc.contributor.authorFörsti, Aen_HK
dc.contributor.authorSieber, Oen_HK
dc.contributor.authorLipton, Len_HK
dc.contributor.authorVan Wezel, Ten_HK
dc.contributor.authorMorreau, Hen_HK
dc.contributor.authorWijnen, JTen_HK
dc.contributor.authorDevilee, Pen_HK
dc.contributor.authorMatsuda, Ken_HK
dc.contributor.authorNakamura, Yen_HK
dc.contributor.authorCastellvíBel, Sen_HK
dc.contributor.authorRuizPonte, Cen_HK
dc.contributor.authorCastells, Aen_HK
dc.contributor.authorCarracedo, Aen_HK
dc.contributor.authorHo, JWCen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorHofstra, RMWen_HK
dc.contributor.authorVodicka, Pen_HK
dc.contributor.authorBrenner, Hen_HK
dc.contributor.authorHampe, Jen_HK
dc.contributor.authorSchafmayer, Cen_HK
dc.contributor.authorTepel, Jen_HK
dc.contributor.authorSchreiber, Sen_HK
dc.contributor.authorVölzke, Hen_HK
dc.contributor.authorLerch, MMen_HK
dc.contributor.authorSchmidt, CAen_HK
dc.contributor.authorBuch, Sen_HK
dc.contributor.authorMoreno, Ven_HK
dc.contributor.authorVillanueva, CMen_HK
dc.contributor.authorPeterlongo, Pen_HK
dc.contributor.authorRadice, Pen_HK
dc.contributor.authorEcheverry, MMen_HK
dc.contributor.authorVelez, Aen_HK
dc.contributor.authorCarvajalCarmona, Len_HK
dc.contributor.authorScott, Ren_HK
dc.contributor.authorPenegar, Sen_HK
dc.contributor.authorBroderick, Pen_HK
dc.contributor.authorTenesa, Aen_HK
dc.contributor.authorHoulston, RSen_HK
dc.date.accessioned2011-03-18T08:26:13Z-
dc.date.available2011-03-18T08:26:13Z-
dc.date.issued2010en_HK
dc.identifier.citationBritish Journal Of Cancer, 2010, v. 102 n. 2, p. 447-454en_HK
dc.identifier.issn0007-0920en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132166-
dc.description.abstractIt is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT. © 2010 Cancer Research UK. All rights reserved.en_HK
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjcen_HK
dc.relation.ispartofBritish Journal of Canceren_HK
dc.subjectAssociationen_HK
dc.subjectColorectal canceren_HK
dc.subjectPolymorphismen_HK
dc.subject.meshColorectal Neoplasms - genetics-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshPenetrance-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshPrognosis-
dc.titleCOGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-0920&volume=102&issue=2&spage=447&epage=454&date=2010&atitle=COGENT+(COlorectal+cancer+GENeTics):+an+international+consortium+to+study+the+role+of+polymorphic+variation+on+the+risk+of+colorectal+cancer-
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/sj.bjc.6605338en_HK
dc.identifier.pmid19920828en_HK
dc.identifier.pmcidPMC2816642-
dc.identifier.scopuseid_2-s2.0-75549083862en_HK
dc.identifier.hkuros168575-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-75549083862&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume102en_HK
dc.identifier.issue2en_HK
dc.identifier.spage447en_HK
dc.identifier.epage454en_HK
dc.identifier.isiWOS:000273728500026-
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dc.identifier.scopusauthoridTomlinson, IPM=7103338177en_HK
dc.identifier.scopusauthoridDunlop, M=7101629955en_HK
dc.identifier.scopusauthoridCampbell, H=7202318417en_HK
dc.identifier.scopusauthoridZanke, B=7003919858en_HK
dc.identifier.scopusauthoridGallinger, S=34975072000en_HK
dc.identifier.scopusauthoridHudson, T=7203069638en_HK
dc.identifier.scopusauthoridKoessler, T=24166668300en_HK
dc.identifier.scopusauthoridPharoah, PD=7102929844en_HK
dc.identifier.scopusauthoridNiittymäkix, I=35741252400en_HK
dc.identifier.scopusauthoridTuupanenx, S=35742101600en_HK
dc.identifier.scopusauthoridAaltonen, LA=7005845446en_HK
dc.identifier.scopusauthoridHemminki, K=36044571800en_HK
dc.identifier.scopusauthoridLindblom, A=7005502801en_HK
dc.identifier.scopusauthoridFörsti, A=7003447292en_HK
dc.identifier.scopusauthoridSieber, O=7003368616en_HK
dc.identifier.scopusauthoridLipton, L=7003275508en_HK
dc.identifier.scopusauthoridVan Wezel, T=6506588846en_HK
dc.identifier.scopusauthoridMorreau, H=7004153007en_HK
dc.identifier.scopusauthoridWijnen, JT=35411281400en_HK
dc.identifier.scopusauthoridDevilee, P=7005413117en_HK
dc.identifier.scopusauthoridMatsuda, K=35327525800en_HK
dc.identifier.scopusauthoridNakamura, Y=35354381800en_HK
dc.identifier.scopusauthoridCastellvíBel, S=6603813137en_HK
dc.identifier.scopusauthoridRuizPonte, C=22135947100en_HK
dc.identifier.scopusauthoridCastells, A=7005902543en_HK
dc.identifier.scopusauthoridCarracedo, A=7006062179en_HK
dc.identifier.scopusauthoridHo, JWC=55166750600en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridHofstra, RMW=7006771436en_HK
dc.identifier.scopusauthoridVodicka, P=7004841464en_HK
dc.identifier.scopusauthoridBrenner, H=7201832825en_HK
dc.identifier.scopusauthoridHampe, J=7006423541en_HK
dc.identifier.scopusauthoridSchafmayer, C=15127848400en_HK
dc.identifier.scopusauthoridTepel, J=15128317000en_HK
dc.identifier.scopusauthoridSchreiber, S=7402870125en_HK
dc.identifier.scopusauthoridVölzke, H=6701830766en_HK
dc.identifier.scopusauthoridLerch, MM=7101988714en_HK
dc.identifier.scopusauthoridSchmidt, CA=36986233800en_HK
dc.identifier.scopusauthoridBuch, S=15126901000en_HK
dc.identifier.scopusauthoridMoreno, V=7103038363en_HK
dc.identifier.scopusauthoridVillanueva, CM=8751722200en_HK
dc.identifier.scopusauthoridPeterlongo, P=6602396930en_HK
dc.identifier.scopusauthoridRadice, P=7005103817en_HK
dc.identifier.scopusauthoridEcheverry, MM=26030403800en_HK
dc.identifier.scopusauthoridVelez, A=7004416147en_HK
dc.identifier.scopusauthoridCarvajalCarmona, L=6508060363en_HK
dc.identifier.scopusauthoridScott, R=7404341627en_HK
dc.identifier.scopusauthoridPenegar, S=15030269400en_HK
dc.identifier.scopusauthoridBroderick, P=15053139600en_HK
dc.identifier.scopusauthoridTenesa, A=8247573400en_HK
dc.identifier.scopusauthoridHoulston, RS=34569730700en_HK
dc.identifier.citeulike6209351-

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