Article: COGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal cancer
| Title | COGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal cancer |
|---|---|
| Authors | Tomlinson, IPM20 Dunlop, M22 Campbell, H22 Zanke, B7 19 21 Gallinger, S16 19 Hudson, T7 Koessler, T15 Pharoah, PD15 Niittymäkix, I10 Tuupanenx, S10 Aaltonen, LA10 Hemminki, K25 Lindblom, A12 Försti, A12 Sieber, O9 Lipton, L9 Van Wezel, T24 Morreau, H24 Wijnen, JT24 Devilee, P24 Matsuda, K18 Nakamura, Y18 CastellvíBel, S17 RuizPonte, C4 Castells, A17 Carracedo, A4 Ho, JWC5 Sham, P5 Hofstra, RMW6 Vodicka, P1 Brenner, H25 Hampe, J14 Schafmayer, C14 Tepel, J14 Schreiber, S14 Völzke, H26 Lerch, MM26 Schmidt, CA26 Buch, S14 Moreno, V17 Villanueva, CM11 Peterlongo, P13 Radice, P13 Echeverry, MM8 Velez, A2 CarvajalCarmona, L8 20 Scott, R23 Penegar, S3 Broderick, P3 Tenesa, A22 Houlston, RS3 |
| Keywords | Association Colorectal cancer Polymorphism |
| Issue Date | 2010 |
| Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc |
| Citation | British Journal Of Cancer, 2010, v. 102 n. 2, p. 447-454 [How to Cite?] DOI: http://dx.doi.org/10.1038/sj.bjc.6605338 |
| Abstract | It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT. © 2010 Cancer Research UK. All rights reserved. |
| ISSN | 0007-0920 2011 Impact Factor: 5.042 2011 SCImago Journal Rankings: 0.561 |
| DOI | http://dx.doi.org/10.1038/sj.bjc.6605338 |
| PubMed Central ID | PMC2816642 |
| References | References in Scopus |
| dc.contributor.author | Tomlinson, IPM | ||||||||||||||||||||||||||||||||||||||||||||||||
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| dc.contributor.author | Dunlop, M | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Campbell, H | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Zanke, B | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Gallinger, S | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Hudson, T | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Koessler, T | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Pharoah, PD | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Niittymäkix, I | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Tuupanenx, S | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Aaltonen, LA | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Hemminki, K | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Lindblom, A | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Försti, A | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Sieber, O | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Lipton, L | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Van Wezel, T | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Morreau, H | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Wijnen, JT | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Devilee, P | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Matsuda, K | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Nakamura, Y | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | CastellvíBel, S | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | RuizPonte, C | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Castells, A | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Carracedo, A | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Ho, JWC | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Sham, P | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Hofstra, RMW | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Vodicka, P | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Brenner, H | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Hampe, J | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Schafmayer, C | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Tepel, J | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Schreiber, S | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Völzke, H | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Lerch, MM | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Schmidt, CA | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Buch, S | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Moreno, V | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Villanueva, CM | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Peterlongo, P | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Radice, P | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Echeverry, MM | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Velez, A | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | CarvajalCarmona, L | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Scott, R | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Penegar, S | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Broderick, P | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Tenesa, A | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.contributor.author | Houlston, RS | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.date.accessioned | 2011-03-18T08:26:13Z | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.date.available | 2011-03-18T08:26:13Z | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.date.issued | 2010 | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.description.abstract | It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT. © 2010 Cancer Research UK. All rights reserved. | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.description.nature | published_or_final_version | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.identifier.citation | British Journal Of Cancer, 2010, v. 102 n. 2, p. 447-454 [How to Cite?] DOI: http://dx.doi.org/10.1038/sj.bjc.6605338 | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.identifier.citeulike | 6209351 | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.identifier.doi | http://dx.doi.org/10.1038/sj.bjc.6605338 | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.identifier.epage | 454 | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.identifier.hkuros | 168575 | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.identifier.isi | WOS:000273728500026
Funding Information: The work of UK groups is supported by grants from Cancer Research UK and the European Union. In Spain, work is supported by grants from the Instituto de Salud Carlos III, grants FIS 05/1006, 08/1359, 08/1635 and European Commission FP6 Food-CT-2006-036224 (VM). In Canada, work is supported by grants from Genome Canada (the ARCTIC Project), the National Cancer Institute of Canada (the CaRE Project) and the Ontario Institute for Cancer Research. In Finland, work is supported by grants from Academy of Finland (Finnish Centre of Excellence Program 20062011), the Sigrid Juselius Foundation, the Finnish Cancer Societies and by the European Union. The work of DFKS is supported by the German Genome Network (NGFNplus). In the Czech Republic, work is supported by GACR 310/07/1430. In Sweden, work is supported by grants from the Swedish Cancer Foundation and the Swedish Research Council. In Barcelona and Santiago (Epicolon), work is supported by grants from Fondo de Investigacion Sanitaria (FIS 04/1126, 05/2031, 05/0071, 08/0025, 08/1276), Xunta de Galicia (PGIDIT07PXIB9101209PR), Fundacion de Investigacion Medica Mutua Madrilena (CRP and SCB), Ministerio de Educacion y Ciencia (SAF 07-64873), Asociacion Espanola contra el Cancer, Fundacion Olga Torres (SCB) and Accion Transversal contra el Cancer (Instituto de Salud Carlos III). CIBERER and CIBEREHD are funded by the Instituto de Salud Carlos III. SCB is supported by a contract from the Fondo de Investigacion Sanitaria (CP 03-0070, Ministerio de Sanidad. Provision of genotyping is gratefully provided by Santiago de Compostela node of the Spanish National Genotyping Center (CeGen). In The Netherlands, work of RH is supported by the Dutch Cancer Society and the European Community, and the work of JTW, TvW, HM and PD is supported by the Dutch Cancer Society (UL2005-3247) and Fonds NutsOhra. In Hong Kong, work is supported by grants from the Michael and Betty Kadoorie Cancer Genetics Research Programme II and by the Bobby Moore Fund of Cancer Research UK. Work in Australia is conducted under the auspices of the Hilton Ludwig Cancer Metastasis Initiative and supported by a grant from the NHMRC (Project Grant 489418). In Japan, this work was conducted as a part of the BioBank Japan Project that was supported by the Ministry of Education, Culture, Sports, Sciences and Technology of the Japanese government. The ESTHER and VERDI studies are supported by grants from the Baden Wurttemberg Ministry of Research, Science and Arts and the German Cancer Aid (Deutsche Krebshilfe, Grant M24/95/BR I). The Kiel cohort (POPGEN) is funded through the German Ministry of Education and Reserach through the POPGEN Biobank grant and the Colon Cancer Network of the German National Genome Research Network. SHIP is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research, the Ministry of Cultural Affairs, as well as by the Social Ministry of the Federal State of Mecklenburg-West Pomerania. Genome-wide data have been supported by the Federal Ministry of Education and Research (Grant no. 03ZIK012) and by a joint grant from Siemens Healthcare, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania. The University of Greifswald is a member of the 'Center of Knowledge Interchange' program of Siemens AG. MME, AV and LC-C have received funding from Cancer Research UK and Universidad del Tolima. | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.identifier.issn | 0007-0920 2011 Impact Factor: 5.042 2011 SCImago Journal Rankings: 0.561 | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.identifier.issue | 2 | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.identifier.openurl | ![]() | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.identifier.pmcid | PMC2816642 | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.identifier.pmid | 19920828 | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.identifier.scopus | eid_2-s2.0-75549083862 | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.identifier.spage | 447 | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/132166 | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.identifier.volume | 102 | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.language | eng | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.publisher.place | United Kingdom | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.relation.ispartof | British Journal of Cancer | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.relation.references | References in Scopus | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.subject.mesh | Colorectal Neoplasms - genetics | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.subject.mesh | Genetic Predisposition to Disease | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.subject.mesh | Penetrance | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.subject.mesh | Polymorphism, Genetic | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.subject.mesh | Prognosis | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.subject | Association | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.subject | Colorectal cancer | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.subject | Polymorphism | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.title | COGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal cancer | ||||||||||||||||||||||||||||||||||||||||||||||||
| dc.type | Article |
- Academy of Sciences of the Czech Republic
- Hospital Pablo Tobon Uribe
- Institute of Cancer Research London
- Universidad de Santiago de Compostela
- The University of Hong Kong
- Universitair Medisch Centrum Groningen
- Ontario Institute for Cancer Research
- Universidad del Tolima
- Royal Melbourne Hospital
- University of Helsinki Faculty of Medicine
- Institut Municipal d'Investigacio Medica
- Karolinska Institutet
- Fondazione IFOM Istituto Firc di Oncologia Molecolare
- Universitätsklinikum Schleswig-Holstein Campus Kiel
- University of Cambridge
- University of Toronto
- Universitat de Barcelona
- University of Tokyo
- Cancer Care Ontario
- University of Oxford
- University of Ottawa, Canada
- University of Edinburgh
- University of Newcastle, Australia
- Leiden University Medical Center - LUMC
- German Cancer Research Center
- null


