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Article: TXNIP regulates germinal center generation by suppressing BCL-6 expression

TitleTXNIP regulates germinal center generation by suppressing BCL-6 expression
Authors
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/immlet
Citation
Immunology Letters, 2010, v. 129 n. 2, p. 78-84 How to Cite?
AbstractThe detailed mechanism driving the germinal center (GC) reaction to B cell lymphomagenesis has not been clarified. Thioredoxin interacting protein (TXNIP), also known as vitamin D3 up-regulated protein 1 which is an important tumor repressor, is involved in stress responses, redox regulation, and cellular proliferation. Here, we report that TXNIP has a potential role in the formation of GC in peripheral lymphoid organs where B lymphocytes divide rapidly. First, we compared changes in GC from wild type mice and Txnip(-/-) mice. After immunization, Txnip(-/-) mice exhibited higher expression level of BCL-6 and larger percentage of GC B cells with the reduction in antibody production and plasma cell numbers. In addition, Txnip(-/-) spleens had a much larger population which expressed Ki-67, a marker of cell proliferation, in the red pulp border than WT spleens. Furthermore, the expression of BCL-6 was decreased in TXNIP overexpressing cells and elevated in TXNIP deficient cells. Taken together, we conclude that TXNIP may contribute to the formation of GCs after immunization. During this process, TXNIP suppresses BCL-6 expression.
Persistent Identifierhttp://hdl.handle.net/10722/131832
ISSN
2015 Impact Factor: 2.483
2015 SCImago Journal Rankings: 1.227
ISI Accession Number ID
Funding AgencyGrant Number
Global Research Laboratory Project
New Drug Target Discovery ProjectM10848000352-08N4800-35210
Ministry of Education. Science & Technology, Republic of Korea
Funding Information:

This work was supported in part by grants from the Global Research Laboratory Project and the New Drug Target Discovery Project (M10848000352-08N4800-35210), the Ministry of Education. Science & Technology, Republic of Korea. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

 

DC FieldValueLanguage
dc.contributor.authorShao, Y-
dc.contributor.authorKim, SY-
dc.contributor.authorShin, D-
dc.contributor.authorKim, MS-
dc.contributor.authorSuh, HW-
dc.contributor.authorPiao, ZH-
dc.contributor.authorJeong, M-
dc.contributor.authorLee, SH-
dc.contributor.authorYoon, SR-
dc.contributor.authorLim, BH-
dc.contributor.authorKim, WH-
dc.contributor.authorAhn, JK-
dc.contributor.authorChoi, I-
dc.date.accessioned2011-02-21T05:28:48Z-
dc.date.available2011-02-21T05:28:48Z-
dc.date.issued2010-
dc.identifier.citationImmunology Letters, 2010, v. 129 n. 2, p. 78-84-
dc.identifier.issn0165-2478-
dc.identifier.urihttp://hdl.handle.net/10722/131832-
dc.description.abstractThe detailed mechanism driving the germinal center (GC) reaction to B cell lymphomagenesis has not been clarified. Thioredoxin interacting protein (TXNIP), also known as vitamin D3 up-regulated protein 1 which is an important tumor repressor, is involved in stress responses, redox regulation, and cellular proliferation. Here, we report that TXNIP has a potential role in the formation of GC in peripheral lymphoid organs where B lymphocytes divide rapidly. First, we compared changes in GC from wild type mice and Txnip(-/-) mice. After immunization, Txnip(-/-) mice exhibited higher expression level of BCL-6 and larger percentage of GC B cells with the reduction in antibody production and plasma cell numbers. In addition, Txnip(-/-) spleens had a much larger population which expressed Ki-67, a marker of cell proliferation, in the red pulp border than WT spleens. Furthermore, the expression of BCL-6 was decreased in TXNIP overexpressing cells and elevated in TXNIP deficient cells. Taken together, we conclude that TXNIP may contribute to the formation of GCs after immunization. During this process, TXNIP suppresses BCL-6 expression.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/immlet-
dc.relation.ispartofImmunology Letters-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshB-Lymphocytes - immunology-
dc.subject.meshCarrier Proteins - immunology-
dc.subject.meshDown-Regulation-
dc.subject.meshGerminal Center - cytology - immunology-
dc.subject.meshProto-Oncogene Proteins c-bcl-6 - genetics - immunology-
dc.titleTXNIP regulates germinal center generation by suppressing BCL-6 expressionen_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0165-2478&volume=129&issue=2&spage=78&epage=84&date=2010&atitle=TXNIP+regulates+germinal+center+generation+by+suppressing+BCL-6+expression-
dc.identifier.emailShao, Y: wellshao@hotmail.com, yshao@hku.hk-
dc.identifier.emailChoi, I: ipchoi@kribb.re.kr-
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.imlet.2010.02.002-
dc.identifier.pmid20156484-
dc.identifier.scopuseid_2-s2.0-77949569715-
dc.identifier.hkuros175361-
dc.identifier.volume129-
dc.identifier.issue2-
dc.identifier.spage78-
dc.identifier.epage84-
dc.identifier.isiWOS:000277061900004-
dc.identifier.citeulike6673584-

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