Article: Acute adverse reactions to magnetic resonance contrast media - Gadolinium chelates

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TitleAcute adverse reactions to magnetic resonance contrast media - Gadolinium chelates
AuthorsLi, A2
Wong, CS1
Wong, MK1
Lee, CM1
Au Yeung, MC1
Issue Date2006
PublisherBritish Institute of Radiology - BJR. The Journal's web site is located at http://bjr.birjournals.org
CitationBritish Journal Of Radiology, 2006, v. 79 n. 941, p. 368-371 [How to Cite?]
DOI: http://dx.doi.org/10.1259/bjr/88469693
AbstractThe objective of this study was to evaluate the clinical safety of intravenous gadolinium-based contrast media used in patients who underwent MRI at a single institution. Acute adverse reactions to intravenous gadolinium-based contrast media used for MRI at the Princess Margaret Hospital, Hong Kong, SAR, from January 1999 to November 2004 were recorded in an incidence log book. The medical records of patients' demographics were retrospectively reviewed and the nature, frequency and severity of the adverse reactions were investigated and documented. The incidence of acute adverse reactions to intravenous gadolinium-based contrast media was 0.48% (45 patients with 46 adverse reactions). The severity of these adverse reactions were 96% mild, 2% moderate (one patient developed shortness of breath that required oxygen supplementation and intravenous steroidal management) and 2% severe (one patient developed an anaphylactoid reaction, but successfully recovered through timely resuscitation). No patients were recorded as having contrast extravasation and none died as a result of any adverse reaction. Among the 45 patients who developed adverse reactions, three patients (6.7%) had prior adverse reactions to iodinated contrast media, three (6.7%) had prior reactions to a different gadolinium-based contrast agent, one (2%) had asthma and nine (20%) had a history of drug/ food allergy. Overall, 41% of the adverse reactions were not documented in the final MRI report or the clinical medical records. Gadolinium-based contrast media are safe and well tolerated by the vast majority of patients. In our study, the adverse reaction rate (0.48%) and the incidence of severe anaphylactoid reaction (0.01%) concur with those reported in the literature. Although most of the symptoms are mild and transient, these adverse reactions must be accurately documented and managed. © 2006 The British Institute of Radiology.
ISSN0007-1285
2011 Impact Factor: 1.314
2011 SCImago Journal Rankings: 0.119
DOIhttp://dx.doi.org/10.1259/bjr/88469693
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLi, A
dc.contributor.authorWong, CS
dc.contributor.authorWong, MK
dc.contributor.authorLee, CM
dc.contributor.authorAu Yeung, MC
dc.date.accessioned2011-02-10T04:00:53Z
dc.date.available2011-02-10T04:00:53Z
dc.date.issued2006
dc.description.abstractThe objective of this study was to evaluate the clinical safety of intravenous gadolinium-based contrast media used in patients who underwent MRI at a single institution. Acute adverse reactions to intravenous gadolinium-based contrast media used for MRI at the Princess Margaret Hospital, Hong Kong, SAR, from January 1999 to November 2004 were recorded in an incidence log book. The medical records of patients' demographics were retrospectively reviewed and the nature, frequency and severity of the adverse reactions were investigated and documented. The incidence of acute adverse reactions to intravenous gadolinium-based contrast media was 0.48% (45 patients with 46 adverse reactions). The severity of these adverse reactions were 96% mild, 2% moderate (one patient developed shortness of breath that required oxygen supplementation and intravenous steroidal management) and 2% severe (one patient developed an anaphylactoid reaction, but successfully recovered through timely resuscitation). No patients were recorded as having contrast extravasation and none died as a result of any adverse reaction. Among the 45 patients who developed adverse reactions, three patients (6.7%) had prior adverse reactions to iodinated contrast media, three (6.7%) had prior reactions to a different gadolinium-based contrast agent, one (2%) had asthma and nine (20%) had a history of drug/ food allergy. Overall, 41% of the adverse reactions were not documented in the final MRI report or the clinical medical records. Gadolinium-based contrast media are safe and well tolerated by the vast majority of patients. In our study, the adverse reaction rate (0.48%) and the incidence of severe anaphylactoid reaction (0.01%) concur with those reported in the literature. Although most of the symptoms are mild and transient, these adverse reactions must be accurately documented and managed. © 2006 The British Institute of Radiology.
dc.description.naturelink_to_OA_fulltext
dc.identifier.citationBritish Journal Of Radiology, 2006, v. 79 n. 941, p. 368-371 [How to Cite?]
DOI: http://dx.doi.org/10.1259/bjr/88469693
dc.identifier.citeulike588967
dc.identifier.doihttp://dx.doi.org/10.1259/bjr/88469693
dc.identifier.epage371
dc.identifier.hkuros174770
dc.identifier.isiWOS:000237511700002
dc.identifier.issn0007-1285
2011 Impact Factor: 1.314
2011 SCImago Journal Rankings: 0.119
dc.identifier.issue941
dc.identifier.openurl
dc.identifier.pmid16632615
dc.identifier.scopuseid_2-s2.0-33646412592
dc.identifier.spage368
dc.identifier.urihttp://hdl.handle.net/10722/131760
dc.identifier.volume79
dc.languageeng
dc.publisherBritish Institute of Radiology - BJR. The Journal's web site is located at http://bjr.birjournals.org
dc.publisher.placeUnited Kingdom
dc.relation.ispartofBritish Journal of Radiology
dc.relation.referencesReferences in Scopus
dc.subject.meshAcute Disease
dc.subject.meshContrast Media - adverse effects
dc.subject.meshDrug Hypersensitivity - etiology
dc.subject.meshGadolinium DTPA - adverse effects
dc.subject.meshMagnetic Resonance Imaging
dc.titleAcute adverse reactions to magnetic resonance contrast media - Gadolinium chelates
dc.typeArticle
Author Affiliations
  1. Princess Margaret Hospital Hong Kong
  2. United Christian Hospital Hong Kong