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Article: Gene expression of synaptosomal-associated protein 25 (SNAP-25) in the prefrontal cortex of the spontaneously hypertensive rat (SHR)

TitleGene expression of synaptosomal-associated protein 25 (SNAP-25) in the prefrontal cortex of the spontaneously hypertensive rat (SHR)
Authors
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbadis
Citation
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009, v. 1792 n. 8, p. 766-776 How to Cite?
AbstractDopamine is believed to play an important role in the etiology of attention-deficit/hyperactivity disorder (ADHD). In our previous study, we showed that gene expression of dopamine D4 receptor decreased in the spontaneously hypertensive rat (SHR) in the prefrontal cortex (PFC). In the present study, we explored the potential causes of dysfunction in the dopamine system in ADHD. It is the first time that neuronal activities in both juvenile SHR and WKY rats have been measured by functional MRI (fMRI). Our results showed that in PFC the Blood Oxygenation Level Dependent (BOLD) signal response in SHR was much higher than WKY under stressful situations. We tested the effects of acute and repeated administration of amphetamine on behavioral changes in SHR combined with the expression of the neuronal activity marker, c-fos, in the PFC. Meanwhile dopamine-related gene expression was measured in the PFC after repeated administration of amphetamine. We found that potential neuronal damage occurred through deficit of D2-like receptor protective functions in the PFC of the SHR. We also measured the expression of synaptosomal-associated protein 25 (SNAP-25) in SHR in PFC. The results showed decreased expression of SNAP-25 mRNA in the PFC of SHR; this defect disappeared after repeated injection of D-AMP.
Persistent Identifierhttp://hdl.handle.net/10722/131756
ISSN
2014 Impact Factor: 4.882
2014 SCImago Journal Rankings: 1.988
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Q-
dc.contributor.authorWong, JH-
dc.contributor.authorLu, G-
dc.contributor.authorAntonio, GE-
dc.contributor.authorYeung, DK-
dc.contributor.authorNg, TB-
dc.contributor.authorForster, LE-
dc.contributor.authorYew, DT-
dc.date.accessioned2011-02-08T06:46:53Z-
dc.date.available2011-02-08T06:46:53Z-
dc.date.issued2009-
dc.identifier.citationBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009, v. 1792 n. 8, p. 766-776-
dc.identifier.issn0925-4439-
dc.identifier.urihttp://hdl.handle.net/10722/131756-
dc.description.abstractDopamine is believed to play an important role in the etiology of attention-deficit/hyperactivity disorder (ADHD). In our previous study, we showed that gene expression of dopamine D4 receptor decreased in the spontaneously hypertensive rat (SHR) in the prefrontal cortex (PFC). In the present study, we explored the potential causes of dysfunction in the dopamine system in ADHD. It is the first time that neuronal activities in both juvenile SHR and WKY rats have been measured by functional MRI (fMRI). Our results showed that in PFC the Blood Oxygenation Level Dependent (BOLD) signal response in SHR was much higher than WKY under stressful situations. We tested the effects of acute and repeated administration of amphetamine on behavioral changes in SHR combined with the expression of the neuronal activity marker, c-fos, in the PFC. Meanwhile dopamine-related gene expression was measured in the PFC after repeated administration of amphetamine. We found that potential neuronal damage occurred through deficit of D2-like receptor protective functions in the PFC of the SHR. We also measured the expression of synaptosomal-associated protein 25 (SNAP-25) in SHR in PFC. The results showed decreased expression of SNAP-25 mRNA in the PFC of SHR; this defect disappeared after repeated injection of D-AMP.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbadis-
dc.relation.ispartofBiochimica et Biophysica Acta (BBA)-
dc.subject.meshAmphetamines - pharmacology-
dc.subject.meshAttention Deficit Disorder with Hyperactivity - metabolism - physiopathology-
dc.subject.meshGene Expression Regulation-
dc.subject.meshRats, Inbred SHR-
dc.subject.meshSynaptosomal-Associated Protein 25 - genetics - metabolism-
dc.titleGene expression of synaptosomal-associated protein 25 (SNAP-25) in the prefrontal cortex of the spontaneously hypertensive rat (SHR)en_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0925-4439&volume=1792 &issue=8&spage=766&epage=776&date=2009&atitle=Gene+expression+of+synaptosomal-associated+protein+25+(SNAP-25)+in+the+prefrontal+cortex+of+the+spontaneously+hypertensive+rat+(SHR)-
dc.identifier.emailLi, Q: ciqi@hku.hk-
dc.identifier.emailYew, DT: david-yew@cuhk.edu.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbadis.2009.05.006-
dc.identifier.pmid19482079-
dc.identifier.scopuseid_2-s2.0-67651085288-
dc.identifier.hkuros175858-
dc.identifier.volume1792-
dc.identifier.issue8-
dc.identifier.spage766-
dc.identifier.epage776-
dc.identifier.isiWOS:000269112500004-
dc.identifier.citeulike5348386-

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