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- Publisher Website: 10.1016/j.bbadis.2009.05.006
- Scopus: eid_2-s2.0-67651085288
- PMID: 19482079
- WOS: WOS:000269112500004
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Article: Gene expression of synaptosomal-associated protein 25 (SNAP-25) in the prefrontal cortex of the spontaneously hypertensive rat (SHR)
Title | Gene expression of synaptosomal-associated protein 25 (SNAP-25) in the prefrontal cortex of the spontaneously hypertensive rat (SHR) |
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Authors | |
Keywords | Attention-deficit/hyperactivity disorder (ADHD) d-amphetamine Functional MRI (fMRI) Prefrontal cortex (PFC) Spontaneously hypertensive rat (SHR) Synaptosomal-associated protein 25 (SNAP-25) |
Issue Date | 2009 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbadis |
Citation | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009, v. 1792 n. 8, p. 766-776 How to Cite? |
Abstract | Dopamine is believed to play an important role in the etiology of attention-deficit/hyperactivity disorder (ADHD). In our previous study, we showed that gene expression of dopamine D4 receptor decreased in the spontaneously hypertensive rat (SHR) in the prefrontal cortex (PFC). In the present study, we explored the potential causes of dysfunction in the dopamine system in ADHD. It is the first time that neuronal activities in both juvenile SHR and WKY rats have been measured by functional MRI (fMRI). Our results showed that in PFC the Blood Oxygenation Level Dependent (BOLD) signal response in SHR was much higher than WKY under stressful situations. We tested the effects of acute and repeated administration of amphetamine on behavioral changes in SHR combined with the expression of the neuronal activity marker, c-fos, in the PFC. Meanwhile dopamine-related gene expression was measured in the PFC after repeated administration of amphetamine. We found that potential neuronal damage occurred through deficit of D2-like receptor protective functions in the PFC of the SHR. We also measured the expression of synaptosomal-associated protein 25 (SNAP-25) in SHR in PFC. The results showed decreased expression of SNAP-25 mRNA in the PFC of SHR; this defect disappeared after repeated injection of D-AMP. |
Persistent Identifier | http://hdl.handle.net/10722/131756 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.580 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, Q | - |
dc.contributor.author | Wong, JH | - |
dc.contributor.author | Lu, G | - |
dc.contributor.author | Antonio, GE | - |
dc.contributor.author | Yeung, DK | - |
dc.contributor.author | Ng, TB | - |
dc.contributor.author | Forster, LE | - |
dc.contributor.author | Yew, DT | - |
dc.date.accessioned | 2011-02-08T06:46:53Z | - |
dc.date.available | 2011-02-08T06:46:53Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009, v. 1792 n. 8, p. 766-776 | - |
dc.identifier.issn | 0925-4439 | - |
dc.identifier.uri | http://hdl.handle.net/10722/131756 | - |
dc.description.abstract | Dopamine is believed to play an important role in the etiology of attention-deficit/hyperactivity disorder (ADHD). In our previous study, we showed that gene expression of dopamine D4 receptor decreased in the spontaneously hypertensive rat (SHR) in the prefrontal cortex (PFC). In the present study, we explored the potential causes of dysfunction in the dopamine system in ADHD. It is the first time that neuronal activities in both juvenile SHR and WKY rats have been measured by functional MRI (fMRI). Our results showed that in PFC the Blood Oxygenation Level Dependent (BOLD) signal response in SHR was much higher than WKY under stressful situations. We tested the effects of acute and repeated administration of amphetamine on behavioral changes in SHR combined with the expression of the neuronal activity marker, c-fos, in the PFC. Meanwhile dopamine-related gene expression was measured in the PFC after repeated administration of amphetamine. We found that potential neuronal damage occurred through deficit of D2-like receptor protective functions in the PFC of the SHR. We also measured the expression of synaptosomal-associated protein 25 (SNAP-25) in SHR in PFC. The results showed decreased expression of SNAP-25 mRNA in the PFC of SHR; this defect disappeared after repeated injection of D-AMP. | - |
dc.language | eng | - |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbadis | - |
dc.relation.ispartof | Biochimica et Biophysica Acta (BBA) | - |
dc.subject | Attention-deficit/hyperactivity disorder (ADHD) | - |
dc.subject | d-amphetamine | - |
dc.subject | Functional MRI (fMRI) | - |
dc.subject | Prefrontal cortex (PFC) | - |
dc.subject | Spontaneously hypertensive rat (SHR) | - |
dc.subject | Synaptosomal-associated protein 25 (SNAP-25) | - |
dc.subject.mesh | Amphetamines - pharmacology | - |
dc.subject.mesh | Attention Deficit Disorder with Hyperactivity - metabolism - physiopathology | - |
dc.subject.mesh | Gene Expression Regulation | - |
dc.subject.mesh | Rats, Inbred SHR | - |
dc.subject.mesh | Synaptosomal-Associated Protein 25 - genetics - metabolism | - |
dc.title | Gene expression of synaptosomal-associated protein 25 (SNAP-25) in the prefrontal cortex of the spontaneously hypertensive rat (SHR) | en_US |
dc.type | Article | en_US |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0925-4439&volume=1792 &issue=8&spage=766&epage=776&date=2009&atitle=Gene+expression+of+synaptosomal-associated+protein+25+(SNAP-25)+in+the+prefrontal+cortex+of+the+spontaneously+hypertensive+rat+(SHR) | - |
dc.identifier.email | Li, Q: ciqi@hku.hk | - |
dc.identifier.email | Yew, DT: david-yew@cuhk.edu.hk | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.bbadis.2009.05.006 | - |
dc.identifier.pmid | 19482079 | - |
dc.identifier.scopus | eid_2-s2.0-67651085288 | - |
dc.identifier.hkuros | 175858 | - |
dc.identifier.volume | 1792 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 766 | - |
dc.identifier.epage | 776 | - |
dc.identifier.isi | WOS:000269112500004 | - |
dc.identifier.citeulike | 5348386 | - |
dc.identifier.issnl | 0925-4439 | - |