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Article: Microfluidic fabrication of monodisperse biocompatible and biodegradable polymersomes with controlled permeability

TitleMicrofluidic fabrication of monodisperse biocompatible and biodegradable polymersomes with controlled permeability
Authors
Issue Date2008
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html
Citation
Journal Of The American Chemical Society, 2008, v. 130 n. 29, p. 9543-9549 How to Cite?
AbstractWe describe a versatile technique for fabricating monodisperse polymersomes with biocompatible and biodegradable diblock copolymers for efficient encapsulation of actives. We use double emulsion as a template for the assembly of amphiphilic diblock copolymers into vesicle structures. These polymersomes can be used to encapsulate small hydrophilic solutes. When triggered by an osmotic shock, the polymersomes break and release the solutes, providing a simple and effective release mechanism. The technique can also be applied to diblock copolymers with different hydrophilic-to-hydrophobic block ratios, or mixtures of diblock copolymers and hydrophobic homopolymers. The ability to make polymer vesicles with copolymers of different block ratios and to incorporate different homopolymers into the polymersomes will allow the tuning of polymersome properties for specific technological applications. © 2008 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/131750
ISSN
2015 Impact Factor: 13.038
2015 SCImago Journal Rankings: 7.123
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, CSen_HK
dc.contributor.authorKim, JWen_HK
dc.contributor.authorWeitz, DAen_HK
dc.date.accessioned2011-02-02T02:00:21Z-
dc.date.available2011-02-02T02:00:21Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of The American Chemical Society, 2008, v. 130 n. 29, p. 9543-9549en_HK
dc.identifier.issn0002-7863en_HK
dc.identifier.urihttp://hdl.handle.net/10722/131750-
dc.description.abstractWe describe a versatile technique for fabricating monodisperse polymersomes with biocompatible and biodegradable diblock copolymers for efficient encapsulation of actives. We use double emulsion as a template for the assembly of amphiphilic diblock copolymers into vesicle structures. These polymersomes can be used to encapsulate small hydrophilic solutes. When triggered by an osmotic shock, the polymersomes break and release the solutes, providing a simple and effective release mechanism. The technique can also be applied to diblock copolymers with different hydrophilic-to-hydrophobic block ratios, or mixtures of diblock copolymers and hydrophobic homopolymers. The ability to make polymer vesicles with copolymers of different block ratios and to incorporate different homopolymers into the polymersomes will allow the tuning of polymersome properties for specific technological applications. © 2008 American Chemical Society.en_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.htmlen_HK
dc.relation.ispartofJournal of the American Chemical Societyen_HK
dc.subject.meshBiocompatible Materials - chemical synthesis - chemistryen_HK
dc.subject.meshEmulsionsen_HK
dc.subject.meshLactates - chemical synthesis - chemistryen_HK
dc.subject.meshMicrofluidic Analytical Techniques - methodsen_HK
dc.subject.meshModels, Molecularen_HK
dc.subject.meshOsmotic Pressureen_HK
dc.subject.meshPermeabilityen_HK
dc.subject.meshPolyethylene Glycols - chemical synthesis - chemistryen_HK
dc.titleMicrofluidic fabrication of monodisperse biocompatible and biodegradable polymersomes with controlled permeabilityen_HK
dc.typeArticleen_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ja802157yen_HK
dc.identifier.pmid18576631-
dc.identifier.scopuseid_2-s2.0-47749135690en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-47749135690&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume130en_HK
dc.identifier.issue29en_HK
dc.identifier.spage9543en_HK
dc.identifier.epage9549en_HK
dc.identifier.isiWOS:000257796500069-
dc.publisher.placeUnited Statesen_HK
dc.identifier.citeulike3047113-

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