File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Impaired intellect and memory: A missing link between genetic risk and schizophrenia?

TitleImpaired intellect and memory: A missing link between genetic risk and schizophrenia?
Authors
Issue Date2010
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archgenpsychiatry.com
Citation
Archives Of General Psychiatry, 2010, v. 67 n. 9, p. 905-913 How to Cite?
AbstractContent: The DSM-IV concept of schizophrenia offers diagnostic reliability but etiologic and pathologic heterogeneity, which probably contributes to the inconsistencies in genetic studies. One solution is to identify intermediate phenotypes, "narrower" constructs of liability, that hypothetically share genetic risk with the disorder. Although a variety of candidate intermediate phenotypes have emerged, few have explicitly quantified the extent of their genetic overlap with schizophrenia. Objective: To quantify the net-shared genetic effects between schizophrenia and specific cognitive candidate intermediate phenotypes. Design: Twin and family design. Setting: Adult psychiatric research centers in the United States and the United Kingdom. Participants: A total of 2056 participants: 657 patients with schizophrenia, 674 first-degree relatives (including co-twins), and 725 controls. Main Outcome Measures: (1) Latent factors capturing the common variance between cognitive tasks, (2) separation of the latent factors into their genetic and environmental components, and (3) estimation of the netshared genetic variance between the latent cognitive factors or intelligence and schizophrenia. Results: Genetic factors contributed substantially to the total variance in cognition (immediate recall latent factor: 0.66; 95% confidence interval [CI], 0.62 to 0.85; delayed recall latent factor: 0.48; 0.42 to 0.55; and intelligence: 0.66; 0.62 to 0.71). The latent common factors for modality-specific immediate and delayed recall and intelligence showed similar levels of phenotypic covariance with schizophrenia (immediate recall: -0.35; delayed recall: -0.37; and intelligence: -0.38), with 72%, 86%, and 89%, respectively, due to shared genetic effects with schizophrenia. Environmental effects accounted for little phenotypic correlation between cognition and schizophrenia. Conclusions: Using the largest international familial schizophrenia cohort to date, we showed that a substantial portion of the phenotypic correlation between schizophrenia and cognition is caused by shared genetic effects. However, because the phenotypic and genetic correlations are far from unity, the genetics of schizophrenia are clearly not merely the genetics of cognition. ©2010 American Medical Association. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/131748
ISSN
2014 Impact Factor: 14.48
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorGoldberg, TEen_HK
dc.contributor.authorRebollo Mesa, Ien_HK
dc.contributor.authorPicchioni, Men_HK
dc.contributor.authorRijsdijk, Fen_HK
dc.contributor.authorStahl, Den_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorFaraone, SVen_HK
dc.contributor.authorTsuang, Men_HK
dc.contributor.authorWeinberger, DRen_HK
dc.contributor.authorSeidman, LJen_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2011-02-01T07:08:52Z-
dc.date.available2011-02-01T07:08:52Z-
dc.date.issued2010en_HK
dc.identifier.citationArchives Of General Psychiatry, 2010, v. 67 n. 9, p. 905-913en_HK
dc.identifier.issn0003-990Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/131748-
dc.description.abstractContent: The DSM-IV concept of schizophrenia offers diagnostic reliability but etiologic and pathologic heterogeneity, which probably contributes to the inconsistencies in genetic studies. One solution is to identify intermediate phenotypes, "narrower" constructs of liability, that hypothetically share genetic risk with the disorder. Although a variety of candidate intermediate phenotypes have emerged, few have explicitly quantified the extent of their genetic overlap with schizophrenia. Objective: To quantify the net-shared genetic effects between schizophrenia and specific cognitive candidate intermediate phenotypes. Design: Twin and family design. Setting: Adult psychiatric research centers in the United States and the United Kingdom. Participants: A total of 2056 participants: 657 patients with schizophrenia, 674 first-degree relatives (including co-twins), and 725 controls. Main Outcome Measures: (1) Latent factors capturing the common variance between cognitive tasks, (2) separation of the latent factors into their genetic and environmental components, and (3) estimation of the netshared genetic variance between the latent cognitive factors or intelligence and schizophrenia. Results: Genetic factors contributed substantially to the total variance in cognition (immediate recall latent factor: 0.66; 95% confidence interval [CI], 0.62 to 0.85; delayed recall latent factor: 0.48; 0.42 to 0.55; and intelligence: 0.66; 0.62 to 0.71). The latent common factors for modality-specific immediate and delayed recall and intelligence showed similar levels of phenotypic covariance with schizophrenia (immediate recall: -0.35; delayed recall: -0.37; and intelligence: -0.38), with 72%, 86%, and 89%, respectively, due to shared genetic effects with schizophrenia. Environmental effects accounted for little phenotypic correlation between cognition and schizophrenia. Conclusions: Using the largest international familial schizophrenia cohort to date, we showed that a substantial portion of the phenotypic correlation between schizophrenia and cognition is caused by shared genetic effects. However, because the phenotypic and genetic correlations are far from unity, the genetics of schizophrenia are clearly not merely the genetics of cognition. ©2010 American Medical Association. All rights reserved.en_HK
dc.languageeng-
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archgenpsychiatry.comen_HK
dc.relation.ispartofArchives of General Psychiatryen_HK
dc.subject.meshCognition Disorders - diagnosis - genetics-
dc.subject.meshMemory Disorders - diagnosis - genetics-
dc.subject.meshMental Retardation - diagnosis - genetics-
dc.subject.meshSchizophrenia - diagnosis - genetics-
dc.subject.meshSchizophrenic Psychology-
dc.titleImpaired intellect and memory: A missing link between genetic risk and schizophrenia?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-990X&volume=67&issue=9&spage=905&epage=913&date=2010&atitle=Impaired+Intellect+and+Memory:+A+Missing+Link+Between+Genetic+Risk+and+Schizophrenia?-
dc.identifier.emailToulopoulou, T: timothea@hku.hken_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1001/archgenpsychiatry.2010.99en_HK
dc.identifier.pmid20819984-
dc.identifier.scopuseid_2-s2.0-77956355318en_HK
dc.identifier.hkuros182501-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956355318&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume67en_HK
dc.identifier.issue9en_HK
dc.identifier.spage905en_HK
dc.identifier.epage913en_HK
dc.identifier.eissn2168-6238-
dc.identifier.isiWOS:000281764000005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridGoldberg, TE=7103004279en_HK
dc.identifier.scopusauthoridRebollo Mesa, I=22935342500en_HK
dc.identifier.scopusauthoridPicchioni, M=6507443795en_HK
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_HK
dc.identifier.scopusauthoridStahl, D=23669226600en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridFaraone, SV=36047714700en_HK
dc.identifier.scopusauthoridTsuang, M=35399577500en_HK
dc.identifier.scopusauthoridWeinberger, DR=7202213462en_HK
dc.identifier.scopusauthoridSeidman, LJ=7006891289en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats