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Article: Influence of bone adaptation on tendon-to-bone healing in bone tunnel after anterior cruciate ligament reconstruction in a rabbit model

TitleInfluence of bone adaptation on tendon-to-bone healing in bone tunnel after anterior cruciate ligament reconstruction in a rabbit model
Authors
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres
Citation
Journal of Orthopaedic Research, 2009, v. 27 n. 11, p. 1447-1456 How to Cite?
AbstractAnterior cruciate ligament (ACL) reconstruction with placement of grafted tendon in bone tunnel is a common surgical procedure. Bone tunnel creation may result in stress shielding of postero-lateral regions of tibial tunnel. The present study was designed to characterize the changes of peri-graft bone and compare with tendon-to-bone (T-B) healing in spatial and temporal manners after ACL reconstruction in rabbit. Surgical reconstruction using digital extensor tendon in bone tunnel was performed on 48 rabbits. Twelve rabbits were sacrificed at 0, 2, 6, and 12 weeks postoperatively for radiological and histological examinations. Bone mass and microarchitecture at the anterior, posterior, medial, and lateral regions of tunnel wall at distal femur and proximal tibia were evaluated. Using peripheral quantitative computed tomography, a 26, 22, and 42% decrease in bone mineral density (BMD) relative to baseline was present in the medial region of the femoral tunnel and the posterior and lateral regions of the tibial tunnel, respectively, at week 12 postoperatively (p < 0.05). It was accompanied by a decrease in trabecular number and increase in trabecular spacing, the shift of platelike to rodlike trabeculae, and loss of anisotropy under micro-computed tomography evaluation. This finding was echoed by histology showing increased osteoclastic activities and poor T-B healing in these regions. In conclusion, the postoperative bone loss and associated poor T-B healing was region-dependent, which may result from adaptive changes after tunnel creation.
Persistent Identifierhttp://hdl.handle.net/10722/131077
ISSN
2015 Impact Factor: 2.807
2015 SCImago Journal Rankings: 1.464
ISI Accession Number ID
Funding AgencyGrant Number
Research Grant Council EarmarkedCUHK4497/06M
Funding Information:

This study was supported by the Research Grant Council Earmarked Grants 06-07 (CUHK4497/06M), Hong Kong SAR, China. The authors would like to thank Po-Yee Lui and Sai-chuen Fu, who provided expertise at academic meetings, as well as Hui-Yan Yeung, Chun-Wai Chan, Grace Ho, and Anita Wai-Ting Shum, who provided technical assistance. The authors would like to thank Qiu Hong for her assistance in statistical analysis.

 

DC FieldValueLanguage
dc.contributor.authorWen, CY-
dc.contributor.authorQin, L-
dc.contributor.authorLee, KM-
dc.contributor.authorWong, MWN-
dc.contributor.authorChan, KM-
dc.date.accessioned2011-01-18T06:48:38Z-
dc.date.available2011-01-18T06:48:38Z-
dc.date.issued2009-
dc.identifier.citationJournal of Orthopaedic Research, 2009, v. 27 n. 11, p. 1447-1456-
dc.identifier.issn0736-0266-
dc.identifier.urihttp://hdl.handle.net/10722/131077-
dc.description.abstractAnterior cruciate ligament (ACL) reconstruction with placement of grafted tendon in bone tunnel is a common surgical procedure. Bone tunnel creation may result in stress shielding of postero-lateral regions of tibial tunnel. The present study was designed to characterize the changes of peri-graft bone and compare with tendon-to-bone (T-B) healing in spatial and temporal manners after ACL reconstruction in rabbit. Surgical reconstruction using digital extensor tendon in bone tunnel was performed on 48 rabbits. Twelve rabbits were sacrificed at 0, 2, 6, and 12 weeks postoperatively for radiological and histological examinations. Bone mass and microarchitecture at the anterior, posterior, medial, and lateral regions of tunnel wall at distal femur and proximal tibia were evaluated. Using peripheral quantitative computed tomography, a 26, 22, and 42% decrease in bone mineral density (BMD) relative to baseline was present in the medial region of the femoral tunnel and the posterior and lateral regions of the tibial tunnel, respectively, at week 12 postoperatively (p < 0.05). It was accompanied by a decrease in trabecular number and increase in trabecular spacing, the shift of platelike to rodlike trabeculae, and loss of anisotropy under micro-computed tomography evaluation. This finding was echoed by histology showing increased osteoclastic activities and poor T-B healing in these regions. In conclusion, the postoperative bone loss and associated poor T-B healing was region-dependent, which may result from adaptive changes after tunnel creation.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres-
dc.relation.ispartofJournal Of Orthopaedic Research-
dc.rightsJournal Of Orthopaedic Research. Copyright © John Wiley & Sons, Inc.-
dc.subject.meshAdaptation, Physiological - physiology-
dc.subject.meshAnimals-
dc.subject.meshAnterior Cruciate Ligament - pathology - surgery-
dc.subject.meshReconstructive Surgical Procedures-
dc.subject.meshTendons - surgery - transplantation-
dc.titleInfluence of bone adaptation on tendon-to-bone healing in bone tunnel after anterior cruciate ligament reconstruction in a rabbit modelen_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0736-0266&volume=27&issue=11&spage=1447&epage=1456&date=2009&atitle=Influence+of+bone+adaptation+on+tendon-to-bone+healing+in+bone+tunnel+after+anterior+cruciate+ligament+reconstruction+in+a+rabbit+model-
dc.identifier.emailWen, CY: paulwen@hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jor.20907-
dc.identifier.pmid19422039-
dc.identifier.scopuseid_2-s2.0-70350223793-
dc.identifier.hkuros174671-
dc.identifier.volume27-
dc.identifier.issue11-
dc.identifier.spage1447-
dc.identifier.epage1456-
dc.identifier.isiWOS:000271310700008-

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