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Article: Seroprevalence of anti-H5 antibodies in rural Cambodia, 2007

TitleSeroprevalence of anti-H5 antibodies in rural Cambodia, 2007
Authors
KeywordsH5N1 virus
Cambodia
Risk factors
Neutralizing antibodies
Seroprevalence
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcv
Citation
Journal of clinical virology, 2010, v. 48 n. 2, p. 123-126 How to Cite?
AbstractBACKGROUND: Since 2005, eight patients with H5N1 infection were laboratory confirmed in Cambodia. Despite the widespread of highly pathogenic avian influenza H5N1 virus and the intense exposure to poultry, there is growing evidence that H5N1 viruses may not be easily transmitted to human. OBJECTIVES: To evaluate the frequency of H5N1 transmission in rural Cambodia, to identify potential risk factors for H5N1 in humans and to explore the extent of asymptomatic and clinically mild illness among humans. STUDY DESIGN: A seroepidemiologic survey was conducted, 9 weeks after the recognition that H5N1 infection caused the death of a 13 years old female in April 2007. Blood specimens were collected from 700 participants for H5N1 serological testing. All participants were interviewed with standardized questionnaire to collect information about poultry exposure. RESULTS: Eighteen (2.6%) of the 700 villagers were tested positive cases for H5N1 antibodies. These 18 individuals were more likely than seronegative participants to report bathing or swimming in the community pond (p=0.04). CONCLUSIONS: The seroprevalence of H5N1 antibodies was higher than previously reported in the other investigations conducted in Cambodia and Thailand. This finding reinforces the overwhelming evidence that the virus continues to circulate widely in settings where human have high exposure to poultry. Our results, provides additional evidence suggesting that bathing or swimming in the community ponds, remains important potential risk factor for H5N1 infection. Both wild birds and domestic poultry have free access to these ponds which are also used for aquaculture through the dumping of poultry feces for fish feeding.
DescriptionShort communication
Persistent Identifierhttp://hdl.handle.net/10722/129961
ISSN
2015 Impact Factor: 2.647
2015 SCImago Journal Rankings: 1.503
ISI Accession Number ID
Funding AgencyGrant Number
World Health Organization, Phnom Penh Cambodia
Institut Pasteur in Cambodia
AFD (Agence Francaise pour le Developpement)
Funding Information:

We thank the Ministry of Health staffs who were responsible for the human case investigation and are grateful to Chan Malen for her support in conducting the survey. The study was generously supported by the World Health Organization, Phnom Penh Cambodia, the Institut Pasteur in Cambodia, and by a grant from the AFD (Agence Francaise pour le Developpement) through SISEA (Surveillance and Investigation of epidemic Situations in South-East Asia), a regional project coordinated by the International Network of Pasteur Institutes.

 

DC FieldValueLanguage
dc.contributor.authorCavailler, Pen_US
dc.contributor.authorChu, Sen_US
dc.contributor.authorLy, Sen_US
dc.contributor.authorGarcia, JMen_US
dc.contributor.authorHa, DQen_US
dc.contributor.authorBergeri, Ien_US
dc.contributor.authorSom, Len_US
dc.contributor.authorLy, Sen_US
dc.contributor.authorSok, Ten_US
dc.contributor.authorVong, Sen_US
dc.contributor.authorBuchy, Pen_US
dc.date.accessioned2010-12-23T08:44:48Z-
dc.date.available2010-12-23T08:44:48Z-
dc.date.issued2010en_US
dc.identifier.citationJournal of clinical virology, 2010, v. 48 n. 2, p. 123-126en_US
dc.identifier.issn1386-6532-
dc.identifier.urihttp://hdl.handle.net/10722/129961-
dc.descriptionShort communication-
dc.description.abstractBACKGROUND: Since 2005, eight patients with H5N1 infection were laboratory confirmed in Cambodia. Despite the widespread of highly pathogenic avian influenza H5N1 virus and the intense exposure to poultry, there is growing evidence that H5N1 viruses may not be easily transmitted to human. OBJECTIVES: To evaluate the frequency of H5N1 transmission in rural Cambodia, to identify potential risk factors for H5N1 in humans and to explore the extent of asymptomatic and clinically mild illness among humans. STUDY DESIGN: A seroepidemiologic survey was conducted, 9 weeks after the recognition that H5N1 infection caused the death of a 13 years old female in April 2007. Blood specimens were collected from 700 participants for H5N1 serological testing. All participants were interviewed with standardized questionnaire to collect information about poultry exposure. RESULTS: Eighteen (2.6%) of the 700 villagers were tested positive cases for H5N1 antibodies. These 18 individuals were more likely than seronegative participants to report bathing or swimming in the community pond (p=0.04). CONCLUSIONS: The seroprevalence of H5N1 antibodies was higher than previously reported in the other investigations conducted in Cambodia and Thailand. This finding reinforces the overwhelming evidence that the virus continues to circulate widely in settings where human have high exposure to poultry. Our results, provides additional evidence suggesting that bathing or swimming in the community ponds, remains important potential risk factor for H5N1 infection. Both wild birds and domestic poultry have free access to these ponds which are also used for aquaculture through the dumping of poultry feces for fish feeding.-
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcv-
dc.relation.ispartofJournal of clinical virologyen_US
dc.subjectH5N1 virus-
dc.subjectCambodia-
dc.subjectRisk factors-
dc.subjectNeutralizing antibodies-
dc.subjectSeroprevalence-
dc.titleSeroprevalence of anti-H5 antibodies in rural Cambodia, 2007en_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1386-6532&volume=48&issue=2&spage=123&epage=126&date=2010&atitle=Seroprevalence+of+anti-H5+antibodies+in+rural+Cambodia,+2007-
dc.identifier.emailCavailler, P: pcavailler@redi.org.sgen_US
dc.identifier.emailGarcia, JM: jmgarcia@HKUCC-COM.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jcv.2010.02.021-
dc.identifier.pmid20356781-
dc.identifier.scopuseid_2-s2.0-77951622123-
dc.identifier.hkuros178063en_US
dc.identifier.volume48en_US
dc.identifier.issue2-
dc.identifier.spage123en_US
dc.identifier.epage126en_US
dc.identifier.isiWOS:000277264300010-
dc.identifier.citeulike6963733-

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