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Conference Paper: The development of an AIDS mucosal vaccine

TitleThe development of an AIDS mucosal vaccine
Authors
Issue Date2009
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijid
Citation
The 3rd Ditan International Conference on Infectious Diseases (DICID 2009), Beijing, China, 30 July-2 August 2009. In International Journal of Infectious Diseases, 2009, v. 13, suppl. 1, p. S20 How to Cite?
AbstractMucosal vaccination offers great advantage for inducing protective immune response at the sites of viral transmission. A novel replication-competent modified vaccinia Tian Tan (MVTT) is an attenuated variant of the wild-type VTT, which was historically used as a smallpox vaccine for millions of people in China. MVTT was generated through genetic engineering and clonal selection of VTT and exhibited excellent safety profiles for mucosal inoculation. The spike glycoprotein (S) of SARS-CoV was used as a test antigen after the S gene was constructed in the identical genomic location of two live vectors to generate vaccine candidates MVTT-S and MVA-S. A head-to-head comparison has been conducted in mice for inducing neutralizing antibodies (Nabs) via mucosal vaccination. Our results indicated that MVTT is superior to MVA for inducing high levels of systemic Nab response post mucosal vaccination. Moreover, a candidate vaccine MVTTSIVgpe, which expresses three major viral structural proteins of simian immunodeficiency virus, has been recently characterized in vitro. The efficacy of MVTT-SIVgpe will be further evaluated in a highly pathogenic SIV/Chinese macaque model.
DescriptionConcurrent Session 14 – AIDS/STD. Abstract no. CS 14-04
Persistent Identifierhttp://hdl.handle.net/10722/129848
ISSN
2015 Impact Factor: 2.229
2015 SCImago Journal Rankings: 1.148

 

DC FieldValueLanguage
dc.contributor.authorChen, Zen_US
dc.date.accessioned2010-12-23T08:42:56Z-
dc.date.available2010-12-23T08:42:56Z-
dc.date.issued2009en_US
dc.identifier.citationThe 3rd Ditan International Conference on Infectious Diseases (DICID 2009), Beijing, China, 30 July-2 August 2009. In International Journal of Infectious Diseases, 2009, v. 13, suppl. 1, p. S20en_US
dc.identifier.issn1201-9712-
dc.identifier.urihttp://hdl.handle.net/10722/129848-
dc.descriptionConcurrent Session 14 – AIDS/STD. Abstract no. CS 14-04-
dc.description.abstractMucosal vaccination offers great advantage for inducing protective immune response at the sites of viral transmission. A novel replication-competent modified vaccinia Tian Tan (MVTT) is an attenuated variant of the wild-type VTT, which was historically used as a smallpox vaccine for millions of people in China. MVTT was generated through genetic engineering and clonal selection of VTT and exhibited excellent safety profiles for mucosal inoculation. The spike glycoprotein (S) of SARS-CoV was used as a test antigen after the S gene was constructed in the identical genomic location of two live vectors to generate vaccine candidates MVTT-S and MVA-S. A head-to-head comparison has been conducted in mice for inducing neutralizing antibodies (Nabs) via mucosal vaccination. Our results indicated that MVTT is superior to MVA for inducing high levels of systemic Nab response post mucosal vaccination. Moreover, a candidate vaccine MVTTSIVgpe, which expresses three major viral structural proteins of simian immunodeficiency virus, has been recently characterized in vitro. The efficacy of MVTT-SIVgpe will be further evaluated in a highly pathogenic SIV/Chinese macaque model.-
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijid-
dc.relation.ispartofInternational Journal of Infectious Diseases-
dc.titleThe development of an AIDS mucosal vaccineen_US
dc.typeConference_Paperen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1201-9712&volume=13, suppl. 1&spage=S20&epage=&date=2009&atitle=The+Development+of+an+AIDS+Mucosal+Vaccine-
dc.identifier.emailChen, Z: zchenai@hkucc.hku.hken_US
dc.identifier.hkuros176721en_US
dc.identifier.volume13-
dc.identifier.issuesuppl. 1-
dc.identifier.spageS20-
dc.identifier.epageS20-

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