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Conference Paper: Southern Chinese patients with systemic lupus erythematosus in Hong Kong have low vitamin D levels

TitleSouthern Chinese patients with systemic lupus erythematosus in Hong Kong have low vitamin D levels
Authors
KeywordsMedical sciences
Issue Date2010
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
Citation
The 15th Medical Research Conference (15th MRC), Department of Medicine, University of Hong Kong, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16 n. 1, suppl. 1, p. 47, abstract no. 77 How to Cite?
Abstract
BACKGROUND: Vitamin D insufficiency has been linked to pathogenesis of autoimmune diseases. This study aimed to measure serum 25(OH)D level in patients with systemic lupus erythematosus (SLE) in Hong Kong and to evaluate association between serum 25(OH)D level and disease activity. METHODS: Serum 25(OH)D level was measured by radioimmunoassay in SLE patients and healthy controls. Lupus disease activity was determined by SLE disease activity index (SLEDAI), serum anti-dsDNA antibody, C3 and C4 levels. RESULTS: Fifty-two SLE patients with mean ± standard deviation disease duration of 15.5±8.6 years were recruited. Five patients had active lupus disease. Five (9.6%) patients had serum 25(OH)D levels <30 nmol/L. Serum 25(OH)D level was significantly lower in SLE patients compared to age- and sex-matched controls (n=52) [45.5±12.3 vs 51.1±12.6 nmol/L, P=0.02]. Serum 25(OH)D levels were not found to be related to SLEDAI, elevated anti-dsDNA antibody, low C3 or C4 levels or medications. One vitamin D insufficient patient had low serum albumin-corrected calcium. Serum 25(OH)D levels were found to correlate negatively with estimated glomerular filtration rate (r= –0.30, P=0.03) but was not different between patients who had normal and impaired renal function (P=0.38). CONCLUSION: SLE patients in Hong Kong were found to have low serum 25(OH)D level despite its subtropical location.
Persistent Identifierhttp://hdl.handle.net/10722/129843
ISSN
2013 SCImago Journal Rankings: 0.293

 

DC FieldValueLanguage
dc.contributor.authorMok, MYen_US
dc.contributor.authorYao, TJen_US
dc.contributor.authorLo, Yen_US
dc.contributor.authorTam, Sen_US
dc.date.accessioned2010-12-23T08:42:50Z-
dc.date.available2010-12-23T08:42:50Z-
dc.date.issued2010en_US
dc.identifier.citationThe 15th Medical Research Conference (15th MRC), Department of Medicine, University of Hong Kong, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16 n. 1, suppl. 1, p. 47, abstract no. 77en_US
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/129843-
dc.description.abstractBACKGROUND: Vitamin D insufficiency has been linked to pathogenesis of autoimmune diseases. This study aimed to measure serum 25(OH)D level in patients with systemic lupus erythematosus (SLE) in Hong Kong and to evaluate association between serum 25(OH)D level and disease activity. METHODS: Serum 25(OH)D level was measured by radioimmunoassay in SLE patients and healthy controls. Lupus disease activity was determined by SLE disease activity index (SLEDAI), serum anti-dsDNA antibody, C3 and C4 levels. RESULTS: Fifty-two SLE patients with mean ± standard deviation disease duration of 15.5±8.6 years were recruited. Five patients had active lupus disease. Five (9.6%) patients had serum 25(OH)D levels <30 nmol/L. Serum 25(OH)D level was significantly lower in SLE patients compared to age- and sex-matched controls (n=52) [45.5±12.3 vs 51.1±12.6 nmol/L, P=0.02]. Serum 25(OH)D levels were not found to be related to SLEDAI, elevated anti-dsDNA antibody, low C3 or C4 levels or medications. One vitamin D insufficient patient had low serum albumin-corrected calcium. Serum 25(OH)D levels were found to correlate negatively with estimated glomerular filtration rate (r= –0.30, P=0.03) but was not different between patients who had normal and impaired renal function (P=0.38). CONCLUSION: SLE patients in Hong Kong were found to have low serum 25(OH)D level despite its subtropical location.-
dc.languageengen_US
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk-
dc.relation.ispartofHong Kong Medical Journalen_US
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectMedical sciences-
dc.titleSouthern Chinese patients with systemic lupus erythematosus in Hong Kong have low vitamin D levelsen_US
dc.typeConference_Paperen_US
dc.identifier.emailMok, MY: temy@hkucc.hku.hken_US
dc.identifier.emailYao, TJ: tjyao@hku.hken_US
dc.identifier.emailLo, Y: yloa@hkucc.hku.hken_US
dc.identifier.emailTam, S: stam@hkucc.hku.hken_US
dc.identifier.authorityMok, MY=rp00490en_US
dc.identifier.authorityYao, TJ=rp00284en_US
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros177406en_US
dc.identifier.volume16en_US
dc.identifier.issue1, suppl. 1-
dc.identifier.spage47en_US
dc.identifier.epage47-
dc.publisher.placeHong Kong-
dc.description.otherThe 15th Medical Research Conference (15th MRC), Department of Medicine, University of Hong Kong, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16 n. 1, suppl. 1, p. 47, abstract no. 77-

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