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Conference Paper: Southern Chinese patients with systemic lupus erythematosus in Hong Kong have low vitamin D levels
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TitleSouthern Chinese patients with systemic lupus erythematosus in Hong Kong have low vitamin D levels
 
AuthorsMok, MY
Yao, TJ
Lo, Y
Tam, S
 
KeywordsMedical sciences
 
Issue Date2010
 
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
 
CitationThe 15th Medical Research Conference (15th MRC), Department of Medicine, University of Hong Kong, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16 n. 1, suppl. 1, p. 47, abstract no. 77 [How to Cite?]
 
AbstractBACKGROUND: Vitamin D insufficiency has been linked to pathogenesis of autoimmune diseases. This study aimed to measure serum 25(OH)D level in patients with systemic lupus erythematosus (SLE) in Hong Kong and to evaluate association between serum 25(OH)D level and disease activity. METHODS: Serum 25(OH)D level was measured by radioimmunoassay in SLE patients and healthy controls. Lupus disease activity was determined by SLE disease activity index (SLEDAI), serum anti-dsDNA antibody, C3 and C4 levels. RESULTS: Fifty-two SLE patients with mean ± standard deviation disease duration of 15.5±8.6 years were recruited. Five patients had active lupus disease. Five (9.6%) patients had serum 25(OH)D levels <30 nmol/L. Serum 25(OH)D level was significantly lower in SLE patients compared to age- and sex-matched controls (n=52) [45.5±12.3 vs 51.1±12.6 nmol/L, P=0.02]. Serum 25(OH)D levels were not found to be related to SLEDAI, elevated anti-dsDNA antibody, low C3 or C4 levels or medications. One vitamin D insufficient patient had low serum albumin-corrected calcium. Serum 25(OH)D levels were found to correlate negatively with estimated glomerular filtration rate (r= –0.30, P=0.03) but was not different between patients who had normal and impaired renal function (P=0.38). CONCLUSION: SLE patients in Hong Kong were found to have low serum 25(OH)D level despite its subtropical location.
 
ISSN1024-2708
2012 SCImago Journal Rankings: 0.255
 
DC FieldValue
dc.contributor.authorMok, MY
 
dc.contributor.authorYao, TJ
 
dc.contributor.authorLo, Y
 
dc.contributor.authorTam, S
 
dc.date.accessioned2010-12-23T08:42:50Z
 
dc.date.available2010-12-23T08:42:50Z
 
dc.date.issued2010
 
dc.description.abstractBACKGROUND: Vitamin D insufficiency has been linked to pathogenesis of autoimmune diseases. This study aimed to measure serum 25(OH)D level in patients with systemic lupus erythematosus (SLE) in Hong Kong and to evaluate association between serum 25(OH)D level and disease activity. METHODS: Serum 25(OH)D level was measured by radioimmunoassay in SLE patients and healthy controls. Lupus disease activity was determined by SLE disease activity index (SLEDAI), serum anti-dsDNA antibody, C3 and C4 levels. RESULTS: Fifty-two SLE patients with mean ± standard deviation disease duration of 15.5±8.6 years were recruited. Five patients had active lupus disease. Five (9.6%) patients had serum 25(OH)D levels <30 nmol/L. Serum 25(OH)D level was significantly lower in SLE patients compared to age- and sex-matched controls (n=52) [45.5±12.3 vs 51.1±12.6 nmol/L, P=0.02]. Serum 25(OH)D levels were not found to be related to SLEDAI, elevated anti-dsDNA antibody, low C3 or C4 levels or medications. One vitamin D insufficient patient had low serum albumin-corrected calcium. Serum 25(OH)D levels were found to correlate negatively with estimated glomerular filtration rate (r= –0.30, P=0.03) but was not different between patients who had normal and impaired renal function (P=0.38). CONCLUSION: SLE patients in Hong Kong were found to have low serum 25(OH)D level despite its subtropical location.
 
dc.description.naturepublished_or_final_version
 
dc.description.otherThe 15th Medical Research Conference (15th MRC), Department of Medicine, University of Hong Kong, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16 n. 1, suppl. 1, p. 47, abstract no. 77
 
dc.identifier.citationThe 15th Medical Research Conference (15th MRC), Department of Medicine, University of Hong Kong, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16 n. 1, suppl. 1, p. 47, abstract no. 77 [How to Cite?]
 
dc.identifier.epage47
 
dc.identifier.hkuros177406
 
dc.identifier.issn1024-2708
2012 SCImago Journal Rankings: 0.255
 
dc.identifier.issue1, suppl. 1
 
dc.identifier.spage47
 
dc.identifier.urihttp://hdl.handle.net/10722/129843
 
dc.identifier.volume16
 
dc.languageeng
 
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
 
dc.publisher.placeHong Kong
 
dc.relation.ispartofHong Kong Medical Journal
 
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectMedical sciences
 
dc.titleSouthern Chinese patients with systemic lupus erythematosus in Hong Kong have low vitamin D levels
 
dc.typeConference_Paper
 
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<item><contributor.author>Mok, MY</contributor.author>
<contributor.author>Yao, TJ</contributor.author>
<contributor.author>Lo, Y</contributor.author>
<contributor.author>Tam, S</contributor.author>
<date.accessioned>2010-12-23T08:42:50Z</date.accessioned>
<date.available>2010-12-23T08:42:50Z</date.available>
<date.issued>2010</date.issued>
<identifier.citation>The 15th Medical Research Conference (15th MRC), Department of Medicine, University of Hong Kong, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16 n. 1, suppl. 1, p. 47, abstract no. 77</identifier.citation>
<identifier.issn>1024-2708</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/129843</identifier.uri>
<description.abstract>BACKGROUND: Vitamin D insufficiency has been linked to pathogenesis of autoimmune diseases. This study aimed to measure serum 25(OH)D level in patients with systemic lupus erythematosus (SLE) in Hong Kong and to evaluate association between serum 25(OH)D level and disease activity. METHODS: Serum 25(OH)D level was measured by radioimmunoassay in SLE patients and healthy controls. Lupus disease activity was determined by SLE disease activity index (SLEDAI), serum anti-dsDNA antibody, C3 and C4 levels. RESULTS: Fifty-two SLE patients with mean &#177; standard deviation disease duration of 15.5&#177;8.6 years were recruited. Five patients had active lupus disease. Five (9.6%) patients had serum 25(OH)D levels &lt;30 nmol/L. Serum 25(OH)D level was significantly lower in SLE patients compared to age- and sex-matched controls (n=52) [45.5&#177;12.3 vs 51.1&#177;12.6 nmol/L, P=0.02]. Serum 25(OH)D levels were not found to be related to SLEDAI, elevated anti-dsDNA antibody, low C3 or C4 levels or medications. One vitamin D insufficient patient had low serum albumin-corrected calcium. Serum 25(OH)D levels were found to correlate negatively with estimated glomerular filtration rate (r= &#8211;0.30, P=0.03) but was not different between patients who had normal and impaired renal function (P=0.38). CONCLUSION: SLE patients in Hong Kong were found to have low serum 25(OH)D level despite its subtropical location.</description.abstract>
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