File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Conference Paper: Endothelial dysfunction is associated with decreased circulating endothelial progenitor cells in patients with systemic sclerosis
  • Basic View
  • Metadata View
  • XML View
TitleEndothelial dysfunction is associated with decreased circulating endothelial progenitor cells in patients with systemic sclerosis
 
AuthorsMok, TMY
Tse, HF
Lo, Y
Wong, RWS
Lau, WCS
 
KeywordsMedical sciences
Rheumatology
 
Issue Date2009
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/
 
CitationThe 2009 ACR/ARHP Annual Scientific Meeting, Philadelphia, PA., 16-21 October 2009. In Arthritis & Rheumatism, 2009, v. 60 suppl. 10 [How to Cite?]
DOI: http://dx.doi.org/10.1002/art.27423
 
AbstractBACKGROUND: The role of circulating bone marrow derived endothelial progenitor cells (EPCs) for vascular repair in scleroderma (SSc) remains unclear. PURPOSE: To examine endothelial dysfunction in SSc patients and to correlate findings with biochemical markers of endothelial injury, circulating EPC count, disease activity and organ involvement. METHODS: Endothelial dependent and independent vasodilation responses were assessed by changes in flow mediated dilation (FMD%) and nitroglycerin challenge (NTG%) in the brachial artery respectively in SSc patients compared to age- and sex- matched controls. Serum levels of vascular endothelial growth factor (VEGF) and soluble vascular cell adhesion molecule (sVCAM)-1 were measured by ELISA. Enumeration of circulating CD133/VEGFR2+ EPCs was performed by flow cytometry. RESULTS: Median FMD% (4.8% vs. 7.8%, P<0.001) and NTG% (17.0% vs. 21.4%, P=0.002) were found to be significantly lower in SSc patients (n=52) than controls (n=52), especially in patients with limited disease (lSSc). Median circulating EPC count was significantly lower in lSSc patients (23.0/ml) compared to controls (73.0/ml) (P<0.001). This was accompanied by higher level of sVCAM-1 in these patients compared to those with diffuse disease (P=0.01). Lower circulating EPC count was found to be associated with high disease activity (P=0.04), abnormal forced vital capacity (P=0.003), longer disease duration (P=0.04), total skin score>20 (P=0.03) and lSSc subset (P<0.001). Multivariate analysis identified disease duration as the only independent predictor for circulating EPC count (P=0.04). CONCLUSION: Endothelial dysfunction was demonstrated in SSc and correlated with biochemical markers of endothelial injury. Lower circulating EPCs might contribute to deficient vascular repair in SSc patients.
 
DescriptionThis journal supplement is the Abstracts of the 2009 ACR/ARHP Annual Scientific Meeting http://www.blackwellpublishing.com/acrmeeting/
Open Access Journal
 
ISSN0004-3591
2013 Impact Factor: 7.871
 
DOIhttp://dx.doi.org/10.1002/art.27423
 
DC FieldValue
dc.contributor.authorMok, TMY
 
dc.contributor.authorTse, HF
 
dc.contributor.authorLo, Y
 
dc.contributor.authorWong, RWS
 
dc.contributor.authorLau, WCS
 
dc.date.accessioned2010-12-23T08:42:46Z
 
dc.date.available2010-12-23T08:42:46Z
 
dc.date.issued2009
 
dc.description.abstractBACKGROUND: The role of circulating bone marrow derived endothelial progenitor cells (EPCs) for vascular repair in scleroderma (SSc) remains unclear. PURPOSE: To examine endothelial dysfunction in SSc patients and to correlate findings with biochemical markers of endothelial injury, circulating EPC count, disease activity and organ involvement. METHODS: Endothelial dependent and independent vasodilation responses were assessed by changes in flow mediated dilation (FMD%) and nitroglycerin challenge (NTG%) in the brachial artery respectively in SSc patients compared to age- and sex- matched controls. Serum levels of vascular endothelial growth factor (VEGF) and soluble vascular cell adhesion molecule (sVCAM)-1 were measured by ELISA. Enumeration of circulating CD133/VEGFR2+ EPCs was performed by flow cytometry. RESULTS: Median FMD% (4.8% vs. 7.8%, P<0.001) and NTG% (17.0% vs. 21.4%, P=0.002) were found to be significantly lower in SSc patients (n=52) than controls (n=52), especially in patients with limited disease (lSSc). Median circulating EPC count was significantly lower in lSSc patients (23.0/ml) compared to controls (73.0/ml) (P<0.001). This was accompanied by higher level of sVCAM-1 in these patients compared to those with diffuse disease (P=0.01). Lower circulating EPC count was found to be associated with high disease activity (P=0.04), abnormal forced vital capacity (P=0.003), longer disease duration (P=0.04), total skin score>20 (P=0.03) and lSSc subset (P<0.001). Multivariate analysis identified disease duration as the only independent predictor for circulating EPC count (P=0.04). CONCLUSION: Endothelial dysfunction was demonstrated in SSc and correlated with biochemical markers of endothelial injury. Lower circulating EPCs might contribute to deficient vascular repair in SSc patients.
 
dc.description.naturelink_to_OA_fulltext
 
dc.descriptionThis journal supplement is the Abstracts of the 2009 ACR/ARHP Annual Scientific Meeting http://www.blackwellpublishing.com/acrmeeting/
 
dc.descriptionOpen Access Journal
 
dc.identifier.citationThe 2009 ACR/ARHP Annual Scientific Meeting, Philadelphia, PA., 16-21 October 2009. In Arthritis & Rheumatism, 2009, v. 60 suppl. 10 [How to Cite?]
DOI: http://dx.doi.org/10.1002/art.27423
 
dc.identifier.doihttp://dx.doi.org/10.1002/art.27423
 
dc.identifier.hkuros177401
 
dc.identifier.issn0004-3591
2013 Impact Factor: 7.871
 
dc.identifier.issuesuppl. 10
 
dc.identifier.urihttp://hdl.handle.net/10722/129835
 
dc.identifier.volume60
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofArthritis & Rheumatism
 
dc.rightsArthritis & Rheumatism. Copyright © John Wiley & Sons, Inc.
 
dc.subjectMedical sciences
 
dc.subjectRheumatology
 
dc.titleEndothelial dysfunction is associated with decreased circulating endothelial progenitor cells in patients with systemic sclerosis
 
dc.typeConference_Paper
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Mok, TMY</contributor.author>
<contributor.author>Tse, HF</contributor.author>
<contributor.author>Lo, Y</contributor.author>
<contributor.author>Wong, RWS</contributor.author>
<contributor.author>Lau, WCS</contributor.author>
<date.accessioned>2010-12-23T08:42:46Z</date.accessioned>
<date.available>2010-12-23T08:42:46Z</date.available>
<date.issued>2009</date.issued>
<identifier.citation>The 2009 ACR/ARHP Annual Scientific Meeting, Philadelphia, PA., 16-21 October 2009. In Arthritis &amp; Rheumatism, 2009, v. 60  suppl. 10</identifier.citation>
<identifier.issn>0004-3591</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/129835</identifier.uri>
<description>This journal supplement is the Abstracts of the 2009 ACR/ARHP Annual Scientific Meeting   http://www.blackwellpublishing.com/acrmeeting/</description>
<description>Open Access Journal</description>
<description.abstract>BACKGROUND: The role of circulating bone marrow derived endothelial progenitor cells (EPCs) for vascular repair in scleroderma (SSc) remains unclear. PURPOSE: To examine endothelial dysfunction in SSc patients and to correlate findings with biochemical markers of endothelial injury, circulating EPC count, disease activity and organ involvement. METHODS: Endothelial dependent and independent vasodilation responses were assessed by changes in flow mediated dilation (FMD%) and nitroglycerin challenge (NTG%) in the brachial artery respectively in SSc patients compared to age- and sex- matched controls. Serum levels of vascular endothelial growth factor (VEGF) and soluble vascular cell adhesion molecule (sVCAM)-1 were measured by ELISA. Enumeration of circulating CD133/VEGFR2+ EPCs was performed by flow cytometry. RESULTS: Median FMD% (4.8% vs. 7.8%, P&lt;0.001) and NTG% (17.0% vs. 21.4%, P=0.002) were found to be significantly lower in SSc patients (n=52) than controls (n=52), especially in patients with limited disease (lSSc). Median circulating EPC count was significantly lower in lSSc patients (23.0/ml) compared to controls (73.0/ml) (P&lt;0.001). This was accompanied by higher level of sVCAM-1 in these patients compared to those with diffuse disease (P=0.01). Lower circulating EPC count was found to be associated with high disease activity (P=0.04), abnormal forced vital capacity (P=0.003), longer disease duration (P=0.04), total skin score&gt;20 (P=0.03) and lSSc subset (P&lt;0.001). Multivariate analysis identified disease duration as the only independent predictor for circulating EPC count (P=0.04). CONCLUSION: Endothelial dysfunction was demonstrated in SSc and correlated with biochemical markers of endothelial injury. Lower circulating EPCs might contribute to deficient vascular repair in SSc patients.</description.abstract>
<language>eng</language>
<publisher>John Wiley &amp; Sons, Inc. The Journal&apos;s web site is located at http://www.interscience.wiley.com/jpages/0004-3591/</publisher>
<relation.ispartof>Arthritis &amp; Rheumatism</relation.ispartof>
<rights>Arthritis &amp; Rheumatism. Copyright &#169; John Wiley &amp; Sons, Inc.</rights>
<subject>Medical sciences</subject>
<subject>Rheumatology</subject>
<title>Endothelial dysfunction is associated with decreased circulating endothelial progenitor cells in patients with systemic sclerosis</title>
<type>Conference_Paper</type>
<description.nature>link_to_OA_fulltext</description.nature>
<identifier.doi>10.1002/art.27423</identifier.doi>
<identifier.hkuros>177401</identifier.hkuros>
<identifier.volume>60</identifier.volume>
<identifier.issue>suppl. 10</identifier.issue>
<publisher.place>United States</publisher.place>
<bitstream.url>http://hub.hku.hk/bitstream/10722/129835/1/re01.htm</bitstream.url>
</item>