Conference Paper: Endothelial dysfunction is associated with decreased circulating endothelial progenitor cells in patients with systemic sclerosis

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Title	Endothelial dysfunction is associated with decreased circulating endothelial progenitor cells in patients with systemic sclerosis
Authors	Mok, TMY Tse, HF Lo, Y Wong, RWS Lau, WCS
Keywords	Medical sciences Rheumatology
Issue Date	2009
Publisher	John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/
Citation	The 2009 ACR/ARHP Annual Scientific Meeting, Philadelphia, PA., 16-21 October 2009. In Arthritis & Rheumatism, 2009, v. 60 suppl. 10 [How to Cite?] DOI: http://dx.doi.org/10.1002/art.27423
Abstract	BACKGROUND: The role of circulating bone marrow derived endothelial progenitor cells (EPCs) for vascular repair in scleroderma (SSc) remains unclear. PURPOSE: To examine endothelial dysfunction in SSc patients and to correlate findings with biochemical markers of endothelial injury, circulating EPC count, disease activity and organ involvement. METHODS: Endothelial dependent and independent vasodilation responses were assessed by changes in flow mediated dilation (FMD%) and nitroglycerin challenge (NTG%) in the brachial artery respectively in SSc patients compared to age- and sex- matched controls. Serum levels of vascular endothelial growth factor (VEGF) and soluble vascular cell adhesion molecule (sVCAM)-1 were measured by ELISA. Enumeration of circulating CD133/VEGFR2+ EPCs was performed by flow cytometry. RESULTS: Median FMD% (4.8% vs. 7.8%, P<0.001) and NTG% (17.0% vs. 21.4%, P=0.002) were found to be significantly lower in SSc patients (n=52) than controls (n=52), especially in patients with limited disease (lSSc). Median circulating EPC count was significantly lower in lSSc patients (23.0/ml) compared to controls (73.0/ml) (P<0.001). This was accompanied by higher level of sVCAM-1 in these patients compared to those with diffuse disease (P=0.01). Lower circulating EPC count was found to be associated with high disease activity (P=0.04), abnormal forced vital capacity (P=0.003), longer disease duration (P=0.04), total skin score>20 (P=0.03) and lSSc subset (P<0.001). Multivariate analysis identified disease duration as the only independent predictor for circulating EPC count (P=0.04). CONCLUSION: Endothelial dysfunction was demonstrated in SSc and correlated with biochemical markers of endothelial injury. Lower circulating EPCs might contribute to deficient vascular repair in SSc patients.
Description	This journal supplement is the Abstracts of the 2009 ACR/ARHP Annual Scientific Meeting http://www.blackwellpublishing.com/acrmeeting/ Open Access Journal
ISSN	0004-3591 2011 Impact Factor: 7.866 2011 SCImago Journal Rankings: 0.871
DOI	http://dx.doi.org/10.1002/art.27423

DC Field	Value
dc.contributor.author	Mok, TMY
dc.contributor.author	Tse, HF
dc.contributor.author	Lo, Y
dc.contributor.author	Wong, RWS
dc.contributor.author	Lau, WCS
dc.date.accessioned	2010-12-23T08:42:46Z
dc.date.available	2010-12-23T08:42:46Z
dc.date.issued	2009
dc.description.abstract	BACKGROUND: The role of circulating bone marrow derived endothelial progenitor cells (EPCs) for vascular repair in scleroderma (SSc) remains unclear. PURPOSE: To examine endothelial dysfunction in SSc patients and to correlate findings with biochemical markers of endothelial injury, circulating EPC count, disease activity and organ involvement. METHODS: Endothelial dependent and independent vasodilation responses were assessed by changes in flow mediated dilation (FMD%) and nitroglycerin challenge (NTG%) in the brachial artery respectively in SSc patients compared to age- and sex- matched controls. Serum levels of vascular endothelial growth factor (VEGF) and soluble vascular cell adhesion molecule (sVCAM)-1 were measured by ELISA. Enumeration of circulating CD133/VEGFR2+ EPCs was performed by flow cytometry. RESULTS: Median FMD% (4.8% vs. 7.8%, P<0.001) and NTG% (17.0% vs. 21.4%, P=0.002) were found to be significantly lower in SSc patients (n=52) than controls (n=52), especially in patients with limited disease (lSSc). Median circulating EPC count was significantly lower in lSSc patients (23.0/ml) compared to controls (73.0/ml) (P<0.001). This was accompanied by higher level of sVCAM-1 in these patients compared to those with diffuse disease (P=0.01). Lower circulating EPC count was found to be associated with high disease activity (P=0.04), abnormal forced vital capacity (P=0.003), longer disease duration (P=0.04), total skin score>20 (P=0.03) and lSSc subset (P<0.001). Multivariate analysis identified disease duration as the only independent predictor for circulating EPC count (P=0.04). CONCLUSION: Endothelial dysfunction was demonstrated in SSc and correlated with biochemical markers of endothelial injury. Lower circulating EPCs might contribute to deficient vascular repair in SSc patients.
dc.description.nature	link_to_OA_fulltext
dc.description	This journal supplement is the Abstracts of the 2009 ACR/ARHP Annual Scientific Meeting http://www.blackwellpublishing.com/acrmeeting/
dc.description	Open Access Journal
dc.identifier.citation	The 2009 ACR/ARHP Annual Scientific Meeting, Philadelphia, PA., 16-21 October 2009. In Arthritis & Rheumatism, 2009, v. 60 suppl. 10 [How to Cite?] DOI: http://dx.doi.org/10.1002/art.27423
dc.identifier.doi	http://dx.doi.org/10.1002/art.27423
dc.identifier.hkuros	177401
dc.identifier.issn	0004-3591 2011 Impact Factor: 7.866 2011 SCImago Journal Rankings: 0.871
dc.identifier.issue	suppl. 10
dc.identifier.uri	http://hdl.handle.net/10722/129835
dc.identifier.volume	60
dc.language	eng
dc.publisher	John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/
dc.publisher.place	United States
dc.relation.ispartof	Arthritis & Rheumatism
dc.rights	Arthritis & Rheumatism. Copyright © John Wiley & Sons, Inc.
dc.subject	Medical sciences
dc.subject	Rheumatology
dc.title	Endothelial dysfunction is associated with decreased circulating endothelial progenitor cells in patients with systemic sclerosis
dc.type	Conference_Paper

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