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Conference Paper: Manganese-enhanced MRI of hypoxic-ischemic brain injuries using Mn-DPDP

TitleManganese-enhanced MRI of hypoxic-ischemic brain injuries using Mn-DPDP
Authors
KeywordsBrain injury
Clinical diagnosis
Contrast agent
Hypointensity
Image contrasts
Issue Date2009
PublisherIEEE. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269
Citation
The 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2009), Minneapolis, MN., 3-6 September 2009. In Proceedings of the 31st EMBC, 2009, p. 4775-4778 How to Cite?
AbstractIn this study, Mn-dipyridoxaldiphosphate (MnDPDP), a clinically approved manganese contrast agent for hepatic and pancreatic imaging, was demonstrated for the first time for manganese-enhanced MRI (MEMRI) in brains of normal young rats (n=4) and rats with hypoxic-ischemic (H-I) insult at postnatal day 7 (n=8). After a single intraperitoneal injection of low dosage with 0.1μmol/g in postnatal 14 days, 2D T1-weighted image (T1WIs), T1 maps, T2-weighted images (T2WIs) and T2 maps were acquired at 7 Tesla 1 day before, 1 day and 7 days after MnDPDP injection. The image contrast changes induced by MnDPDP appeared as the hyperintensity in T1WIs and the hypointensity in T2WIs. T1and T2 values decreased in the regions of Mn enhancement. Such enhancement presented as a delayed pattern that was more pronounced in 7 day after MnDPDP injection, suggesting the sustained Mn accumulation due to MnDPDP. Moreover, the MnDPDP enhancement in H-I brains was more pronounced in the lesion sites and was easily detectable in T1WI, T1 map, T2WI and T2 map. The results demonstrated here support the possibility of using MnDPDP as a 'slow release' Mn2+ for clinical diagnosis of various neuropathologies. ©2009 IEEE.
DescriptionTheme: Engineering the Future of Biomedicine
Persistent Identifierhttp://hdl.handle.net/10722/129726
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorYang, Jen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-12-23T08:41:18Z-
dc.date.available2010-12-23T08:41:18Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2009), Minneapolis, MN., 3-6 September 2009. In Proceedings of the 31st EMBC, 2009, p. 4775-4778en_HK
dc.identifier.issn1557-170Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/129726-
dc.descriptionTheme: Engineering the Future of Biomedicine-
dc.description.abstractIn this study, Mn-dipyridoxaldiphosphate (MnDPDP), a clinically approved manganese contrast agent for hepatic and pancreatic imaging, was demonstrated for the first time for manganese-enhanced MRI (MEMRI) in brains of normal young rats (n=4) and rats with hypoxic-ischemic (H-I) insult at postnatal day 7 (n=8). After a single intraperitoneal injection of low dosage with 0.1μmol/g in postnatal 14 days, 2D T1-weighted image (T1WIs), T1 maps, T2-weighted images (T2WIs) and T2 maps were acquired at 7 Tesla 1 day before, 1 day and 7 days after MnDPDP injection. The image contrast changes induced by MnDPDP appeared as the hyperintensity in T1WIs and the hypointensity in T2WIs. T1and T2 values decreased in the regions of Mn enhancement. Such enhancement presented as a delayed pattern that was more pronounced in 7 day after MnDPDP injection, suggesting the sustained Mn accumulation due to MnDPDP. Moreover, the MnDPDP enhancement in H-I brains was more pronounced in the lesion sites and was easily detectable in T1WI, T1 map, T2WI and T2 map. The results demonstrated here support the possibility of using MnDPDP as a 'slow release' Mn2+ for clinical diagnosis of various neuropathologies. ©2009 IEEE.en_HK
dc.languageengen_US
dc.publisherIEEE. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269-
dc.relation.ispartofProceedings of the Annual International Conference of the IEEE Engineering In Medicine And Biology Society, EMBC 2009en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsIEEE Engineering in Medicine and Biology Society. Conference Proceedings. Copyright © IEEE.-
dc.rights©2009 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.-
dc.subjectBrain injury-
dc.subjectClinical diagnosis-
dc.subjectContrast agent-
dc.subjectHypointensity-
dc.subjectImage contrasts-
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newbornen_HK
dc.subject.meshContrast Media - chemistry - diagnostic useen_HK
dc.subject.meshEdetic Acid - analogs & derivatives - chemistry - diagnostic useen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHypoxia-Ischemia, Brain - diagnosisen_HK
dc.subject.meshMagnetic Resonance Imaging - methodsen_HK
dc.subject.meshManganese - chemistryen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshPyridoxal Phosphate - analogs & derivatives - chemistry - diagnostic useen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.titleManganese-enhanced MRI of hypoxic-ischemic brain injuries using Mn-DPDPen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=&spage=4775&epage=4778&date=2009&atitle=Manganese-enhanced+MRI+of+hypoxic-ischemic+brain+injuries+using+Mn-DPDP-
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1109/IEMBS.2009.5334210en_HK
dc.identifier.pmid19964849-
dc.identifier.scopuseid_2-s2.0-77951002860en_HK
dc.identifier.hkuros178156en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951002860&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.spage4775en_HK
dc.identifier.epage4778en_HK
dc.publisher.placeUnited Statesen_HK
dc.description.otherThe 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2009), Minneapolis, MN., 3-6 September 2009. In Proceedings of the 31st EMBC, 2009, p. 4775-4778-
dc.identifier.scopusauthoridYang, J=10041733800en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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