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Conference Paper: 1H MRS of cortical and subcortical structures in mild and severe neonatal hypoxia-ischemic cerebral injuries

Title1H MRS of cortical and subcortical structures in mild and severe neonatal hypoxia-ischemic cerebral injuries
Authors
Issue Date2010
Citation
The ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden, 1-7 May 2010. How to Cite?
Abstract
This study employed in vivo 1H MRS to understand the metabolic alterations in cortical and subcortical structures during the recovery period upon mild and severe hypoxic-ischemic (HI) injuries to the neonatal rat brains. Relative to the Cr peak, results showed a further increase in Cho, Glu and Lac in the left cortex of severe HI group than mild HI group at 3 days after HI injury at postnatal day 7. These values then decreased slightly at 7 days after surgery in both HI groups. Tau also increased on both sides of the cortex at Day 3 and then drop at Day 7 for both HI groups. In the left thalamus of the severe HI group, NAA appeared to decrease transiently at Day 3 and normalize at Day 7, whereas Cho, Glu, Lac and Tau levels apparently peaked at Day 3. The results of this study may help to investigate potential therapies and the recovery mechanisms upon different severity of neonatal HI insults.
DescriptionPosters - MRS of Animal Brain: No. 4532
Persistent Identifierhttp://hdl.handle.net/10722/129721

 

DC FieldValueLanguage
dc.contributor.authorChan, CWen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2010-12-23T08:41:16Z-
dc.date.available2010-12-23T08:41:16Z-
dc.date.issued2010en_US
dc.identifier.citationThe ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden, 1-7 May 2010.en_US
dc.identifier.urihttp://hdl.handle.net/10722/129721-
dc.descriptionPosters - MRS of Animal Brain: No. 4532-
dc.description.abstractThis study employed in vivo 1H MRS to understand the metabolic alterations in cortical and subcortical structures during the recovery period upon mild and severe hypoxic-ischemic (HI) injuries to the neonatal rat brains. Relative to the Cr peak, results showed a further increase in Cho, Glu and Lac in the left cortex of severe HI group than mild HI group at 3 days after HI injury at postnatal day 7. These values then decreased slightly at 7 days after surgery in both HI groups. Tau also increased on both sides of the cortex at Day 3 and then drop at Day 7 for both HI groups. In the left thalamus of the severe HI group, NAA appeared to decrease transiently at Day 3 and normalize at Day 7, whereas Cho, Glu, Lac and Tau levels apparently peaked at Day 3. The results of this study may help to investigate potential therapies and the recovery mechanisms upon different severity of neonatal HI insults.-
dc.languageengen_US
dc.relation.ispartofISMRM-ESMRMB Joint Annual Meeting-
dc.title1H MRS of cortical and subcortical structures in mild and severe neonatal hypoxia-ischemic cerebral injuriesen_US
dc.typeConference_Paperen_US
dc.identifier.emailWu, EX: ewu@eee.hku.hken_US
dc.identifier.hkuros178249en_US

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