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Conference Paper: 1H MRS of cortical and subcortical structures in mild and severe neonatal hypoxia-ischemic cerebral injuries
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Title1H MRS of cortical and subcortical structures in mild and severe neonatal hypoxia-ischemic cerebral injuries
 
AuthorsChan, CW
Wu, EX
 
Issue Date2010
 
CitationThe ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden, 1-7 May 2010. [How to Cite?]
 
AbstractThis study employed in vivo 1H MRS to understand the metabolic alterations in cortical and subcortical structures during the recovery period upon mild and severe hypoxic-ischemic (HI) injuries to the neonatal rat brains. Relative to the Cr peak, results showed a further increase in Cho, Glu and Lac in the left cortex of severe HI group than mild HI group at 3 days after HI injury at postnatal day 7. These values then decreased slightly at 7 days after surgery in both HI groups. Tau also increased on both sides of the cortex at Day 3 and then drop at Day 7 for both HI groups. In the left thalamus of the severe HI group, NAA appeared to decrease transiently at Day 3 and normalize at Day 7, whereas Cho, Glu, Lac and Tau levels apparently peaked at Day 3. The results of this study may help to investigate potential therapies and the recovery mechanisms upon different severity of neonatal HI insults.
 
DescriptionPosters - MRS of Animal Brain: No. 4532
 
DC FieldValue
dc.contributor.authorChan, CW
 
dc.contributor.authorWu, EX
 
dc.date.accessioned2010-12-23T08:41:16Z
 
dc.date.available2010-12-23T08:41:16Z
 
dc.date.issued2010
 
dc.description.abstractThis study employed in vivo 1H MRS to understand the metabolic alterations in cortical and subcortical structures during the recovery period upon mild and severe hypoxic-ischemic (HI) injuries to the neonatal rat brains. Relative to the Cr peak, results showed a further increase in Cho, Glu and Lac in the left cortex of severe HI group than mild HI group at 3 days after HI injury at postnatal day 7. These values then decreased slightly at 7 days after surgery in both HI groups. Tau also increased on both sides of the cortex at Day 3 and then drop at Day 7 for both HI groups. In the left thalamus of the severe HI group, NAA appeared to decrease transiently at Day 3 and normalize at Day 7, whereas Cho, Glu, Lac and Tau levels apparently peaked at Day 3. The results of this study may help to investigate potential therapies and the recovery mechanisms upon different severity of neonatal HI insults.
 
dc.descriptionPosters - MRS of Animal Brain: No. 4532
 
dc.identifier.citationThe ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden, 1-7 May 2010. [How to Cite?]
 
dc.identifier.hkuros178249
 
dc.identifier.urihttp://hdl.handle.net/10722/129721
 
dc.languageeng
 
dc.relation.ispartofISMRM-ESMRMB Joint Annual Meeting
 
dc.title1H MRS of cortical and subcortical structures in mild and severe neonatal hypoxia-ischemic cerebral injuries
 
dc.typeConference_Paper
 
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<item><contributor.author>Chan, CW</contributor.author>
<contributor.author>Wu, EX</contributor.author>
<date.accessioned>2010-12-23T08:41:16Z</date.accessioned>
<date.available>2010-12-23T08:41:16Z</date.available>
<date.issued>2010</date.issued>
<identifier.citation>The ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden, 1-7 May 2010.</identifier.citation>
<identifier.uri>http://hdl.handle.net/10722/129721</identifier.uri>
<description>Posters - MRS of Animal Brain: No. 4532</description>
<description.abstract>This study employed in vivo 1H MRS to understand the metabolic alterations in cortical and subcortical structures during the recovery period upon mild and severe hypoxic-ischemic (HI) injuries to the neonatal rat brains. Relative to the Cr peak, results showed a further increase in Cho, Glu and Lac in the left cortex of severe HI group than mild HI group at 3 days after HI injury at postnatal day 7. These values then decreased slightly at 7 days after surgery in both HI groups. Tau also increased on both sides of the cortex at Day 3 and then drop at Day 7 for both HI groups. In the left thalamus of the severe HI group, NAA appeared to decrease transiently at Day 3 and normalize at Day 7, whereas Cho, Glu, Lac and Tau levels apparently peaked at Day 3. The results of this study may help to investigate potential therapies and the recovery mechanisms upon different severity of neonatal HI insults.</description.abstract>
<language>eng</language>
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<title>1H MRS of cortical and subcortical structures in mild and severe neonatal hypoxia-ischemic cerebral injuries</title>
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