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Conference Paper: Gas-filled microbubbles: a novel susceptibility contrast agent for brain and liver MRI

TitleGas-filled microbubbles: a novel susceptibility contrast agent for brain and liver MRI
Authors
KeywordsBlood pool
Contrast agent
High field
In-vitro
Issue Date2009
PublisherIEEE. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269
Citation
The 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2009), Minneapolis, MN., 3-6 September 2009. In Proceedings of the 31st EMBC, 2009, p. 4049-4052 How to Cite?
AbstractGas-filled microbubbles have the potential to become a unique intravascular MR contrast agent due to their magnetic susceptibility effect, biocompatibility and localized manipulation via ultrasound cavitation. However, in vivo demonstration of microbubble susceptibility effect is limited so far and microbubble susceptibility effect is relatively weak when compared with other intravascular MR susceptibility contrast agents. In this study, two types of microbubbles, custom-made albumin-coated microbubbles (AMBs) and a commercially available lipid-based clinical ultrasound contrast agent (SonoVue® ), were investigated with in vivo dynamic brain and liver MRI in Sprague-Dawley rats at 7 Tesla. Transverse relaxation rate enhancements (ΔR2*) maps were computed for brain and liver, yielding results similar to those obtained with a common MR blood pool contrast agent. These results indicate that gas-filled microbubbles can serve as an intravascular MR contrast agent at high field. Enhancement of microbubble susceptibility effect by entrapping monocrystalline iron oxide nanoparticles (MIONs) into microbubbles was also investigated at 7 T in vitro. This is the first experimental demonstration of microbubble susceptibility enhancement for MRI application. This study indicates that gas-filled microbubble susceptibility effect can be substantially increased using iron oxides nanoparticles. With such approach, microbubbles can potentially be visualized with higher sensitivity and lower concentrations by MRI. Such capability has the potential to lead to real-time MRI guidance in various microbubble-based drug delivery and therapeutic applications. ©2009 IEEE.
DescriptionTheme: Engineering the Future of Biomedicine
Persistent Identifierhttp://hdl.handle.net/10722/129694
ISSN
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChow, AMen_HK
dc.contributor.authorCheung, JSen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-12-23T08:41:05Z-
dc.date.available2010-12-23T08:41:05Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2009), Minneapolis, MN., 3-6 September 2009. In Proceedings of the 31st EMBC, 2009, p. 4049-4052en_HK
dc.identifier.issn1557-170Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/129694-
dc.descriptionTheme: Engineering the Future of Biomedicine-
dc.description.abstractGas-filled microbubbles have the potential to become a unique intravascular MR contrast agent due to their magnetic susceptibility effect, biocompatibility and localized manipulation via ultrasound cavitation. However, in vivo demonstration of microbubble susceptibility effect is limited so far and microbubble susceptibility effect is relatively weak when compared with other intravascular MR susceptibility contrast agents. In this study, two types of microbubbles, custom-made albumin-coated microbubbles (AMBs) and a commercially available lipid-based clinical ultrasound contrast agent (SonoVue® ), were investigated with in vivo dynamic brain and liver MRI in Sprague-Dawley rats at 7 Tesla. Transverse relaxation rate enhancements (ΔR2*) maps were computed for brain and liver, yielding results similar to those obtained with a common MR blood pool contrast agent. These results indicate that gas-filled microbubbles can serve as an intravascular MR contrast agent at high field. Enhancement of microbubble susceptibility effect by entrapping monocrystalline iron oxide nanoparticles (MIONs) into microbubbles was also investigated at 7 T in vitro. This is the first experimental demonstration of microbubble susceptibility enhancement for MRI application. This study indicates that gas-filled microbubble susceptibility effect can be substantially increased using iron oxides nanoparticles. With such approach, microbubbles can potentially be visualized with higher sensitivity and lower concentrations by MRI. Such capability has the potential to lead to real-time MRI guidance in various microbubble-based drug delivery and therapeutic applications. ©2009 IEEE.en_HK
dc.languageengen_US
dc.publisherIEEE. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269-
dc.relation.ispartofProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2009en_HK
dc.rightsIEEE Engineering in Medicine and Biology Society. Conference Proceedings. Copyright © IEEE.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rights©2009 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.-
dc.subjectBlood pool-
dc.subjectContrast agent-
dc.subjectHigh field-
dc.subjectIn-vitro-
dc.subject.meshAlbumins - chemistryen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBrain - pathologyen_HK
dc.subject.meshContrast Media - pharmacologyen_HK
dc.subject.meshDrug Carriersen_HK
dc.subject.meshDrug Delivery Systemsen_HK
dc.subject.meshFerric Compoundsen_HK
dc.subject.meshGasesen_HK
dc.subject.meshImage Processing, Computer-Assisted - methodsen_HK
dc.subject.meshLipids - chemistryen_HK
dc.subject.meshLiver - pathologyen_HK
dc.subject.meshMagnetic Resonance Imaging - methodsen_HK
dc.subject.meshMicrobubblesen_HK
dc.subject.meshPhospholipids - pharmacologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshSulfur Hexafluoride - pharmacologyen_HK
dc.titleGas-filled microbubbles: a novel susceptibility contrast agent for brain and liver MRIen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=&spage=4049&epage=4052&date=2009&atitle=Gas-filled+microbubbles+-+a+novel+susceptibility+contrast+agent+for+brain+and+liver+MRI-
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1109/IEMBS.2009.5333171en_HK
dc.identifier.pmid19964096-
dc.identifier.scopuseid_2-s2.0-77950973396en_HK
dc.identifier.hkuros178153en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950973396&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.spage4049en_HK
dc.identifier.epage4052en_HK
dc.identifier.isiWOS:000280543603104-
dc.publisher.placeUnited Statesen_HK
dc.description.otherThe 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2009), Minneapolis, MN., 3-6 September 2009. In Proceedings of the 31st EMBC, 2009, p. 4049-4052-
dc.identifier.scopusauthoridChow, AM=16174234200en_HK
dc.identifier.scopusauthoridCheung, JS=16174280400en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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