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Conference Paper: The effects of hypercapnia on DTI quantification in anesthetized rat brain

TitleThe effects of hypercapnia on DTI quantification in anesthetized rat brain
Authors
KeywordsCerebral vascular
Diffusivity quantification
DTI
Hypercapnia
Issue Date2009
PublisherIEEE. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269
Citation
The 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2009), Minneapolis, MN., 3-6 September 2009. In Proceedings of the 31st EMBC, 2009, p. 2711-2714 How to Cite?
AbstractDiffusion Tensor Imaging (DTI) offers a valuable in vivo tool to characterize water diffusion behavior in biological tissues, particularly brain tissues. The accuracy of DTI derived parameters can directly affect the interpretation of underlying microstructures, physiology or pathologies. It is anticipated that measurement of apparent diffusion coefficient (ADC) using DTI could be influenced and complicated by the presence of water molecules in brain vasculature. However, little is known about to what degree does blood signal from vasculature affect the diffusion quantitation. In this study, we examined the effects of hypercapnia on DTI quantification in rat brains using inhalation of 5% carbon dioxide (CO2). It was found that statistically significant changes occurred in parametric DTI maps in response to cerebrovascular challenges, indicating that vascular factors could interfere with in vivo DTI characterization of neural tissues. Consequently, hemodynamic alterations can potentially affect the DTI quantitation and detection of tissue microstructures and pathological alterations. Therefore, cautions must be taken when interpreting DTI parameters in vivo. ©2009 IEEE.
DescriptionTheme: Engineering the Future of Biomedicine
Persistent Identifierhttp://hdl.handle.net/10722/129681
ISSN
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDing, AYen_HK
dc.contributor.authorHui, ESen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-12-23T08:40:57Z-
dc.date.available2010-12-23T08:40:57Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2009), Minneapolis, MN., 3-6 September 2009. In Proceedings of the 31st EMBC, 2009, p. 2711-2714en_HK
dc.identifier.issn1557-170Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/129681-
dc.descriptionTheme: Engineering the Future of Biomedicine-
dc.description.abstractDiffusion Tensor Imaging (DTI) offers a valuable in vivo tool to characterize water diffusion behavior in biological tissues, particularly brain tissues. The accuracy of DTI derived parameters can directly affect the interpretation of underlying microstructures, physiology or pathologies. It is anticipated that measurement of apparent diffusion coefficient (ADC) using DTI could be influenced and complicated by the presence of water molecules in brain vasculature. However, little is known about to what degree does blood signal from vasculature affect the diffusion quantitation. In this study, we examined the effects of hypercapnia on DTI quantification in rat brains using inhalation of 5% carbon dioxide (CO2). It was found that statistically significant changes occurred in parametric DTI maps in response to cerebrovascular challenges, indicating that vascular factors could interfere with in vivo DTI characterization of neural tissues. Consequently, hemodynamic alterations can potentially affect the DTI quantitation and detection of tissue microstructures and pathological alterations. Therefore, cautions must be taken when interpreting DTI parameters in vivo. ©2009 IEEE.en_HK
dc.languageengen_US
dc.publisherIEEE. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269-
dc.relation.ispartofProceedings of the 31st Annual International Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2009en_HK
dc.rightsIEEE Engineering in Medicine and Biology Society. Conference Proceedings. Copyright © IEEE.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rights©2009 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.-
dc.subjectCerebral vascularen_HK
dc.subjectDiffusivity quantificationen_HK
dc.subjectDTIen_HK
dc.subjectHypercapniaen_HK
dc.subject.meshAlgorithmsen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBrain - pathologyen_HK
dc.subject.meshBrain Mapping - methodsen_HK
dc.subject.meshCarbon Dioxide - chemistryen_HK
dc.subject.meshCerebrovascular Circulationen_HK
dc.subject.meshDiffusionen_HK
dc.subject.meshDiffusion Magnetic Resonance Imaging - instrumentation - methodsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHemodynamicsen_HK
dc.subject.meshHypercapnia - pathologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshSignal Processing, Computer-Assisteden_HK
dc.subject.meshTime Factorsen_HK
dc.titleThe effects of hypercapnia on DTI quantification in anesthetized rat brainen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=&spage=2711&epage=2714&date=2009&atitle=The+effects+of+hypercapnia+on+DTI+quantification+in+anesthetized+rat+brain-
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1109/IEMBS.2009.5333392en_HK
dc.identifier.pmid19964038-
dc.identifier.scopuseid_2-s2.0-77950996293en_HK
dc.identifier.hkuros178149en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950996293&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.spage2711en_HK
dc.identifier.epage2714en_HK
dc.identifier.isiWOS:000280543602042-
dc.publisher.placeUnited Statesen_HK
dc.description.otherThe 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2009), Minneapolis, MN., 3-6 September 2009. In Proceedings of the 31st EMBC, 2009, p. 2711-2714-
dc.identifier.scopusauthoridDing, AY=35745892100en_HK
dc.identifier.scopusauthoridHui, ES=16175117100en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.citeulike8155369-

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