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Article: Optimal timing for the administration of intranasal dexmedetomidine for premedication in children

TitleOptimal timing for the administration of intranasal dexmedetomidine for premedication in children
Authors
Issue Date2010
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0003-2409
Citation
Anaesthesia, 2010, v. 65 n. 9, p. 922-929 How to Cite?
AbstractPrevious studies have shown that 1 μg.kg -1 intranasal dexmedetomidine produces significant sedation in children aged between 2 and 12 years. This investigation was designed to evaluate the onset time. One hundred children aged 1-12 years of ASA physical status 1-2 undergoing elective surgery were randomly allocated to five groups. Patients in groups A to D received intranasal dexmedetomidine 1 μg.kg -1. Patients in Group E received intranasal placebo (0.9% saline). Children from groups A, B, C, D and E had intravenous cannulation attempted at 30, 45, 60, 75 and 45 min respectively after intranasal drug or placebo administration. Vital signs, behaviour and sedation status of the children were assessed regularly until induction of anaesthesia. More children from groups A to D achieved satisfactory sedation at the time of cannulation when compared to group E (p < 0.001). The proportion of children who achieved satisfactory sedation was not significantly different among groups A to D. Overall 62% of the children who received intranasal dexmedetomidine had satisfactory sedation at the time of cannulation. The median (95% CI) time for onset of sedation was 25 (25-30) min. The median (95% CI) duration of sedation was 85 (55-100) min. © 2010 The Association of Anaesthetists of Great Britain and Ireland.
Persistent Identifierhttp://hdl.handle.net/10722/129542
ISSN
2015 Impact Factor: 3.794
2015 SCImago Journal Rankings: 1.404
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, VMen_HK
dc.contributor.authorHui, TWen_HK
dc.contributor.authorIrwin, MGen_HK
dc.contributor.authorYao, TJen_HK
dc.contributor.authorWong, GLen_HK
dc.contributor.authorYuen, MKen_HK
dc.date.accessioned2010-12-23T08:38:40Z-
dc.date.available2010-12-23T08:38:40Z-
dc.date.issued2010en_HK
dc.identifier.citationAnaesthesia, 2010, v. 65 n. 9, p. 922-929en_HK
dc.identifier.issn0003-2409en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129542-
dc.description.abstractPrevious studies have shown that 1 μg.kg -1 intranasal dexmedetomidine produces significant sedation in children aged between 2 and 12 years. This investigation was designed to evaluate the onset time. One hundred children aged 1-12 years of ASA physical status 1-2 undergoing elective surgery were randomly allocated to five groups. Patients in groups A to D received intranasal dexmedetomidine 1 μg.kg -1. Patients in Group E received intranasal placebo (0.9% saline). Children from groups A, B, C, D and E had intravenous cannulation attempted at 30, 45, 60, 75 and 45 min respectively after intranasal drug or placebo administration. Vital signs, behaviour and sedation status of the children were assessed regularly until induction of anaesthesia. More children from groups A to D achieved satisfactory sedation at the time of cannulation when compared to group E (p < 0.001). The proportion of children who achieved satisfactory sedation was not significantly different among groups A to D. Overall 62% of the children who received intranasal dexmedetomidine had satisfactory sedation at the time of cannulation. The median (95% CI) time for onset of sedation was 25 (25-30) min. The median (95% CI) duration of sedation was 85 (55-100) min. © 2010 The Association of Anaesthetists of Great Britain and Ireland.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0003-2409en_HK
dc.relation.ispartofAnaesthesiaen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subject.meshAdministration, Intranasal-
dc.subject.meshAge Distribution-
dc.subject.meshDexmedetomidine - administration and dosage-
dc.subject.meshHypnotics and Sedatives - administration and dosage-
dc.subject.meshPremedication - methods-
dc.titleOptimal timing for the administration of intranasal dexmedetomidine for premedication in childrenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-2409&volume=65&issue=9&spage=922&epage=929&date=2010&atitle=Optimal+timing+for+the+administration+of+intranasal+dexmedetomidine+for+premedication+in+children-
dc.identifier.emailIrwin, MG: mgirwin@hku.hken_HK
dc.identifier.emailYao, TJ: tjyao@hkucc.hku.hken_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.identifier.authorityYao, TJ=rp00284en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1365-2044.2010.06453.xen_HK
dc.identifier.pmid20645951-
dc.identifier.scopuseid_2-s2.0-77956133530en_HK
dc.identifier.hkuros176965en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956133530&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume65en_HK
dc.identifier.issue9en_HK
dc.identifier.spage922en_HK
dc.identifier.epage929en_HK
dc.identifier.isiWOS:000281309800011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYuen, VM=8590467800en_HK
dc.identifier.scopusauthoridHui, TW=7005618934en_HK
dc.identifier.scopusauthoridIrwin, MG=7202411076en_HK
dc.identifier.scopusauthoridYao, TJ=7401886444en_HK
dc.identifier.scopusauthoridWong, GL=55040779200en_HK
dc.identifier.scopusauthoridYuen, MK=18042888000en_HK

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