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- Publisher Website: 10.1155/2010/682504
- PMID: 20814443
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Article: Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis
Title | Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis |
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Authors | |
Issue Date | 2010 |
Publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ogi/ |
Citation | Obstetrics and Gynecology International, 2010, p. Article no. 682504 How to Cite? |
Abstract | This paper aimed at investigating the expression and methylation profiles of SOX2, a gene coding for the stem cell-related transcription factor SOX2, in endometrial carcinomas. By methylation-specific polymerase chain reaction (MS-PCR), the methylation status of SOX2 promoter region in 72 endometrial carcinomas and 12 normal endometrial samples was examined. Methylated allele was found in 37.5% (27/72) of endometrial carcinomas but only in 8.3% (1/12) of normal endometrial, significantly more frequent in cancers (P = .0472). SOX2 mRNA level was significantly reduced in endometrial carcinoma compared with nonneoplastic endometrium (P = .045). A significant correlation between SOX2 mRNA expression and hypermethylation of SOX2 was found (P = .024). Hypermethylation of SOX2 tended to be more frequently found in type II serous or clear cell adenocarcinoma. SOX2 methylation was also significantly correlated with shorter survival of patients (P = .046). In conclusion, epigenetic mechanisms may play a crucial role on the transcriptional regulation of SOX2 and loss of SOX2 expression may be related to endometrial carcinogenesis. |
Persistent Identifier | http://hdl.handle.net/10722/129514 |
ISSN | 2023 Impact Factor: 1.6 2023 SCImago Journal Rankings: 0.412 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wong, OGW | - |
dc.contributor.author | Huo, Z | - |
dc.contributor.author | Siu, MKY | - |
dc.contributor.author | Zhang, H | - |
dc.contributor.author | Jiang, L | - |
dc.contributor.author | Wong, ESY | - |
dc.contributor.author | Cheung, ANY | - |
dc.date.accessioned | 2010-12-23T08:38:20Z | - |
dc.date.available | 2010-12-23T08:38:20Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Obstetrics and Gynecology International, 2010, p. Article no. 682504 | - |
dc.identifier.issn | 1687-9589 | - |
dc.identifier.uri | http://hdl.handle.net/10722/129514 | - |
dc.description.abstract | This paper aimed at investigating the expression and methylation profiles of SOX2, a gene coding for the stem cell-related transcription factor SOX2, in endometrial carcinomas. By methylation-specific polymerase chain reaction (MS-PCR), the methylation status of SOX2 promoter region in 72 endometrial carcinomas and 12 normal endometrial samples was examined. Methylated allele was found in 37.5% (27/72) of endometrial carcinomas but only in 8.3% (1/12) of normal endometrial, significantly more frequent in cancers (P = .0472). SOX2 mRNA level was significantly reduced in endometrial carcinoma compared with nonneoplastic endometrium (P = .045). A significant correlation between SOX2 mRNA expression and hypermethylation of SOX2 was found (P = .024). Hypermethylation of SOX2 tended to be more frequently found in type II serous or clear cell adenocarcinoma. SOX2 methylation was also significantly correlated with shorter survival of patients (P = .046). In conclusion, epigenetic mechanisms may play a crucial role on the transcriptional regulation of SOX2 and loss of SOX2 expression may be related to endometrial carcinogenesis. | - |
dc.language | eng | - |
dc.publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ogi/ | - |
dc.relation.ispartof | Obstetrics and Gynecology International | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis | - |
dc.type | Article | - |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1687-9589&volume=article no. 682504&spage=&epage=&date=2010&atitle=Hypermethylation+of+SOX2+Promoter+in+Endometrial+Carcinogenesis | - |
dc.identifier.email | Wong, OGW: wonggw@HKUCC.hku.hk | - |
dc.identifier.email | Siu, MKY: mkysiu@hkusua.hku.hk | - |
dc.identifier.email | Zhang, H: drzhanghj@yahoo.com.cn | - |
dc.identifier.email | Jiang, L: jianglily@pathology.hku.hk | - |
dc.identifier.email | Wong, ESY: esywong@hkucc.hku.hk | - |
dc.identifier.email | Cheung, ANY: anycheun@hkucc.hku.hk, anycheun@pathology.hku.hk | - |
dc.identifier.authority | Siu, MKY=rp00275 | - |
dc.identifier.authority | Cheung, ANY=rp00542 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1155/2010/682504 | - |
dc.identifier.pmid | 20814443 | - |
dc.identifier.pmcid | PMC2929617 | - |
dc.identifier.hkuros | 176680 | - |
dc.identifier.isi | WOS:000216549700038 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1687-9597 | - |