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Article: Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis

TitleHypermethylation of SOX2 Promoter in Endometrial Carcinogenesis
Authors
Issue Date2010
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ogi/
Citation
Obstetrics and Gynecology International, 2010, article no. 682504 How to Cite?
AbstractThis paper aimed at investigating the expression and methylation profiles of SOX2, a gene coding for the stem cell-related transcription factor SOX2, in endometrial carcinomas. By methylation-specific polymerase chain reaction (MS-PCR), the methylation status of SOX2 promoter region in 72 endometrial carcinomas and 12 normal endometrial samples was examined. Methylated allele was found in 37.5% (27/72) of endometrial carcinomas but only in 8.3% (1/12) of normal endometrial, significantly more frequent in cancers (P = .0472). SOX2 mRNA level was significantly reduced in endometrial carcinoma compared with nonneoplastic endometrium (P = .045). A significant correlation between SOX2 mRNA expression and hypermethylation of SOX2 was found (P = .024). Hypermethylation of SOX2 tended to be more frequently found in type II serous or clear cell adenocarcinoma. SOX2 methylation was also significantly correlated with shorter survival of patients (P = .046). In conclusion, epigenetic mechanisms may play a crucial role on the transcriptional regulation of SOX2 and loss of SOX2 expression may be related to endometrial carcinogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/129514
ISSN
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorWong, OGWen_US
dc.contributor.authorHuo, Zen_US
dc.contributor.authorSiu, MKYen_US
dc.contributor.authorZhang, Hen_US
dc.contributor.authorJiang, Len_US
dc.contributor.authorWong, ESYen_US
dc.contributor.authorCheung, ANYen_US
dc.date.accessioned2010-12-23T08:38:20Z-
dc.date.available2010-12-23T08:38:20Z-
dc.date.issued2010en_US
dc.identifier.citationObstetrics and Gynecology International, 2010, article no. 682504en_US
dc.identifier.issn1687-9589-
dc.identifier.urihttp://hdl.handle.net/10722/129514-
dc.description.abstractThis paper aimed at investigating the expression and methylation profiles of SOX2, a gene coding for the stem cell-related transcription factor SOX2, in endometrial carcinomas. By methylation-specific polymerase chain reaction (MS-PCR), the methylation status of SOX2 promoter region in 72 endometrial carcinomas and 12 normal endometrial samples was examined. Methylated allele was found in 37.5% (27/72) of endometrial carcinomas but only in 8.3% (1/12) of normal endometrial, significantly more frequent in cancers (P = .0472). SOX2 mRNA level was significantly reduced in endometrial carcinoma compared with nonneoplastic endometrium (P = .045). A significant correlation between SOX2 mRNA expression and hypermethylation of SOX2 was found (P = .024). Hypermethylation of SOX2 tended to be more frequently found in type II serous or clear cell adenocarcinoma. SOX2 methylation was also significantly correlated with shorter survival of patients (P = .046). In conclusion, epigenetic mechanisms may play a crucial role on the transcriptional regulation of SOX2 and loss of SOX2 expression may be related to endometrial carcinogenesis.-
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ogi/-
dc.relation.ispartofObstetrics and Gynecology International-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleHypermethylation of SOX2 Promoter in Endometrial Carcinogenesisen_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1687-9589&volume=article no. 682504&spage=&epage=&date=2010&atitle=Hypermethylation+of+SOX2+Promoter+in+Endometrial+Carcinogenesis-
dc.identifier.emailWong, OGW: wonggw@HKUCC.hku.hken_US
dc.identifier.emailSiu, MKY: mkysiu@hkusua.hku.hken_US
dc.identifier.emailZhang, H: drzhanghj@yahoo.com.cnen_US
dc.identifier.emailJiang, L: jianglily@pathology.hku.hken_US
dc.identifier.emailWong, ESY: esywong@hkucc.hku.hken_US
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hk, anycheun@pathology.hku.hken_US
dc.identifier.authoritySiu, MKY=rp00275en_US
dc.identifier.authorityCheung, ANY=rp00542en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2010/682504-
dc.identifier.pmid20814443-
dc.identifier.pmcidPMC2929617-
dc.identifier.hkuros176680en_US
dc.identifier.volumearticle no. 682504-

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