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Article: Oseltamivir for treatment and prevention of pandemic influenza A/H1N1 virus infection in households, Milwaukee, 2009

TitleOseltamivir for treatment and prevention of pandemic influenza A/H1N1 virus infection in households, Milwaukee, 2009
Authors
Issue Date2010
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/
Citation
Bmc Infectious Diseases, 2010, v. 10 How to Cite?
AbstractBackground: During an influenza pandemic, a substantial proportion of transmission is thought to occur in households. We used data on influenza progression in individuals and their contacts collected by the City of Milwaukee Health Department (MHD) to study the transmission of pandemic influenza A/H1N1 virus in 362 households in Milwaukee, WI, and the effects of oseltamivir treatment and chemoprophylaxis.Methods: 135 households had chronological information on symptoms and oseltamivir usage for all household members. The effect of oseltamivir treatment and other factors on the household secondary attack rate was estimated using univariate and multivariate logistic regression with households as the unit of analysis. The effect of oseltamivir treatment and other factors on the individual secondary attack rate was estimated using univariate and multivariate logistic regression with individual household contacts as the unit of analysis, and a generalized estimating equations approach was used to fit the model to allow for clustering within households.Results: Oseltamivir index treatment on onset day or the following day (early treatment) was associated with a 42% reduction (OR: 0.58, 95% CI: 0.19, 1.73) in the odds of one or more secondary infections in a household and a 50% reduction (OR: 0.5, 95% CI: 0.17, 1.46) in the odds of a secondary infection in individual contacts. The confidence bounds are wide due to a small sample of households with early oseltamivir index usage - in 29 such households, 5 had a secondary attack. Younger household contacts were at higher risk of infection (OR: 2.79, 95% CI: 1.50-5.20).Conclusions: Early oseltamivir treatment may be beneficial in preventing H1N1pdm influenza transmission; this may have relevance to future control measures for influenza pandemics. Larger randomized trials are needed to confirm this finding statistically. © 2010 Goldstein et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/129472
ISSN
2015 Impact Factor: 2.69
2015 SCImago Journal Rankings: 1.510
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
US National Institutes of Health5U01GM076497
1U54GM088558
Science & Technology Directorate, Department of Homeland Security
Fogarty International Center, National Institutes of Health
Funding Information:

This work was funded by the US National Institutes of Health Models of Infectious Disease Agent Study Cooperative Agreements 5U01GM076497 and 1U54GM088558 to ML for the Harvard Center for Communicable Disease Dynamics (ML, EG, JO), and by the RAPIDD program of the Science & Technology Directorate, Department of Homeland Security, and the Fogarty International Center, National Institutes of Health (JCM).

References

 

DC FieldValueLanguage
dc.contributor.authorGoldstein, Een_HK
dc.contributor.authorCowling, BJen_HK
dc.contributor.authorO'Hagan, JJen_HK
dc.contributor.authorDanon, Len_HK
dc.contributor.authorFang, VJen_HK
dc.contributor.authorHagy, Aen_HK
dc.contributor.authorMiller, JCen_HK
dc.contributor.authorReshef, Den_HK
dc.contributor.authorRobins, Jen_HK
dc.contributor.authorBiedrzycki, Pen_HK
dc.contributor.authorLipsitch, Men_HK
dc.date.accessioned2010-12-23T08:37:45Z-
dc.date.available2010-12-23T08:37:45Z-
dc.date.issued2010en_HK
dc.identifier.citationBmc Infectious Diseases, 2010, v. 10en_HK
dc.identifier.issn1471-2334en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129472-
dc.description.abstractBackground: During an influenza pandemic, a substantial proportion of transmission is thought to occur in households. We used data on influenza progression in individuals and their contacts collected by the City of Milwaukee Health Department (MHD) to study the transmission of pandemic influenza A/H1N1 virus in 362 households in Milwaukee, WI, and the effects of oseltamivir treatment and chemoprophylaxis.Methods: 135 households had chronological information on symptoms and oseltamivir usage for all household members. The effect of oseltamivir treatment and other factors on the household secondary attack rate was estimated using univariate and multivariate logistic regression with households as the unit of analysis. The effect of oseltamivir treatment and other factors on the individual secondary attack rate was estimated using univariate and multivariate logistic regression with individual household contacts as the unit of analysis, and a generalized estimating equations approach was used to fit the model to allow for clustering within households.Results: Oseltamivir index treatment on onset day or the following day (early treatment) was associated with a 42% reduction (OR: 0.58, 95% CI: 0.19, 1.73) in the odds of one or more secondary infections in a household and a 50% reduction (OR: 0.5, 95% CI: 0.17, 1.46) in the odds of a secondary infection in individual contacts. The confidence bounds are wide due to a small sample of households with early oseltamivir index usage - in 29 such households, 5 had a secondary attack. Younger household contacts were at higher risk of infection (OR: 2.79, 95% CI: 1.50-5.20).Conclusions: Early oseltamivir treatment may be beneficial in preventing H1N1pdm influenza transmission; this may have relevance to future control measures for influenza pandemics. Larger randomized trials are needed to confirm this finding statistically. © 2010 Goldstein et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/en_HK
dc.relation.ispartofBMC Infectious Diseasesen_HK
dc.rightsB M C Infectious Diseases. Copyright © BioMed Central Ltd.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAdult-
dc.subject.meshAntiviral Agents - administration and dosage-
dc.subject.meshInfluenza A Virus, H1N1 Subtype - isolation and purification-
dc.subject.meshInfluenza, Human - drug therapy - prevention and control - transmission - virology-
dc.subject.meshOseltamivir - administration and dosage-
dc.titleOseltamivir for treatment and prevention of pandemic influenza A/H1N1 virus infection in households, Milwaukee, 2009en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1471-2334&volume=10&issue=211&spage=&epage=&date=2010&atitle=Oseltamivir+for+treatment+and+prevention+of+pandemic+influenza+A/H1N1+virus+infection+in+households,+Milwaukee,+2009-
dc.identifier.emailCowling, BJ:bcowling@hku.hken_HK
dc.identifier.authorityCowling, BJ=rp01326en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1471-2334-10-211en_HK
dc.identifier.pmid20642862-
dc.identifier.pmcidPMC2919545-
dc.identifier.scopuseid_2-s2.0-77954676992en_HK
dc.identifier.hkuros176507en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954676992&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue211en_US
dc.identifier.isiWOS:000283138900001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridGoldstein, E=35344973300en_HK
dc.identifier.scopusauthoridCowling, BJ=8644765500en_HK
dc.identifier.scopusauthoridO'Hagan, JJ=22234869700en_HK
dc.identifier.scopusauthoridDanon, L=6603245188en_HK
dc.identifier.scopusauthoridFang, VJ=24474130400en_HK
dc.identifier.scopusauthoridHagy, A=35302485000en_HK
dc.identifier.scopusauthoridMiller, JC=34880614600en_HK
dc.identifier.scopusauthoridReshef, D=36337314300en_HK
dc.identifier.scopusauthoridRobins, J=35392741100en_HK
dc.identifier.scopusauthoridBiedrzycki, P=6505768594en_HK
dc.identifier.scopusauthoridLipsitch, M=7006236353en_HK
dc.identifier.citeulike7531556-

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