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Article: Smoking cessation and carotid atherosclerosis: The guangzhou biobank cohort studydCVD

TitleSmoking cessation and carotid atherosclerosis: The guangzhou biobank cohort studydCVD
Authors
Issue Date2010
PublisherB M J Publishing Group. The Journal's web site is located at http://jech.bmjjournals.com/
Citation
Journal Of Epidemiology And Community Health, 2010, v. 64 n. 11, p. 1004-1009 How to Cite?
AbstractIntroduction Smoking has been shown to be associated with carotid atherosclerosis in cross-sectional and prospective studies in Western populations. However, few studies have examined the reversal of risk resulting from quitting smoking, and the results are conflicting. Methods 959 men aged 50e85 years were randomly selected from phase III (2006e2007) of the Guangzhou Biobank Cohort Study into this cross-sectional study. Common carotid artery intima-media thickness (CCAIMT) was measured by B-mode ultrasonography, and carotid artery plaques were identified. Major cardiovascular risk factors, including fasting triglyceride, low-density and high-density lipoprotein (LDL and HDL) cholesterol and glucose, and systolic and diastolic blood pressure, were assessed. Results CCA-IMT and the number of carotid plaque increased from never to former to current smokers (both p≤0.001). Among former smokers compared to current smokers, after adjustment for cigarette pack-years and other potential confounders, the adjusted ORs (95% CI) for quitting for 1-9, 10-19 and 20+ years were 0.77 (0.47 to 1.26), 0.45 (0.26 to 0.79) and 0.37 (0.17 to 0.77) for the presence of CCA atherosclerosis, and 0.69 (0.43 to 1.12), 0.47 (0.27 to 0.82) and 0.45 (0.23 to 0.96) for the presence of carotid plaques, respectively. Longer duration of quitting smoking was also significantly associated with decreasing risk of the severity of CCA atherosclerosis and carotid plaques (all p≤0.001). Conclusion Smoking cessation was beneficial in attenuating the risk of carotid atherosclerosis associated with cigarette smoking. The short duration of cessation in earlier studies is a likely explanation for the inconsistent results.
Persistent Identifierhttp://hdl.handle.net/10722/129460
ISSN
2015 Impact Factor: 3.865
2015 SCImago Journal Rankings: 1.890
ISI Accession Number ID
Funding AgencyGrant Number
NSFC/RGC30518001
HKU720/05
University of Hong Kong Foundation for Educational Development and Research, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Bureau, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study is funded by an NSFC/RGC (No 30518001; HKU720/05) grant; The University of Hong Kong Foundation for Educational Development and Research, Hong Kong; the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau, Guangzhou, China; and University of Birmingham, UK.

References

 

DC FieldValueLanguage
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorXu, Len_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLin, JMen_HK
dc.contributor.authorCheng, KKen_HK
dc.contributor.authorThomas, GNen_HK
dc.date.accessioned2010-12-23T08:37:38Z-
dc.date.available2010-12-23T08:37:38Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Epidemiology And Community Health, 2010, v. 64 n. 11, p. 1004-1009en_HK
dc.identifier.issn0143-005Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/129460-
dc.description.abstractIntroduction Smoking has been shown to be associated with carotid atherosclerosis in cross-sectional and prospective studies in Western populations. However, few studies have examined the reversal of risk resulting from quitting smoking, and the results are conflicting. Methods 959 men aged 50e85 years were randomly selected from phase III (2006e2007) of the Guangzhou Biobank Cohort Study into this cross-sectional study. Common carotid artery intima-media thickness (CCAIMT) was measured by B-mode ultrasonography, and carotid artery plaques were identified. Major cardiovascular risk factors, including fasting triglyceride, low-density and high-density lipoprotein (LDL and HDL) cholesterol and glucose, and systolic and diastolic blood pressure, were assessed. Results CCA-IMT and the number of carotid plaque increased from never to former to current smokers (both p≤0.001). Among former smokers compared to current smokers, after adjustment for cigarette pack-years and other potential confounders, the adjusted ORs (95% CI) for quitting for 1-9, 10-19 and 20+ years were 0.77 (0.47 to 1.26), 0.45 (0.26 to 0.79) and 0.37 (0.17 to 0.77) for the presence of CCA atherosclerosis, and 0.69 (0.43 to 1.12), 0.47 (0.27 to 0.82) and 0.45 (0.23 to 0.96) for the presence of carotid plaques, respectively. Longer duration of quitting smoking was also significantly associated with decreasing risk of the severity of CCA atherosclerosis and carotid plaques (all p≤0.001). Conclusion Smoking cessation was beneficial in attenuating the risk of carotid atherosclerosis associated with cigarette smoking. The short duration of cessation in earlier studies is a likely explanation for the inconsistent results.en_HK
dc.languageengen_US
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jech.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Epidemiology and Community Healthen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleSmoking cessation and carotid atherosclerosis: The guangzhou biobank cohort studydCVDen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0143-005X&volume=64&issue=11&spage=1004&epage=1009&date=2010&atitle=Smoking+cessation+and+carotid+atherosclerosis:+The+Guangzhou+Biobank+Cohort+Study+-+CVD-
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1136/jech.2009.092718en_HK
dc.identifier.pmid19825787-
dc.identifier.scopuseid_2-s2.0-78149256777en_HK
dc.identifier.hkuros183382en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78149256777&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume64en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1004en_HK
dc.identifier.epage1009en_HK
dc.identifier.isiWOS:000283176000013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridXu, L=36648217500en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridLin, JM=35763917400en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK

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