File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.annepidem.2010.06.011
- Scopus: eid_2-s2.0-78149463269
- PMID: 20727786
- WOS: WOS:000284669000010
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Does the age of achieving pubertal landmarks predict cognition in older men? Guangzhou biobank cohort study
Title | Does the age of achieving pubertal landmarks predict cognition in older men? Guangzhou biobank cohort study | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Authors | |||||||||||
Keywords | Cognition Epidemiology Puberty | ||||||||||
Issue Date | 2010 | ||||||||||
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/annepidem | ||||||||||
Citation | Annals Of Epidemiology, 2010, v. 20 n. 12, p. 948-954 How to Cite? | ||||||||||
Abstract | Purpose: Earlier pubertal maturation in women may be associated with better cognition. It is unclear whether or not this also occurs in men. We tested the hypothesis that earlier pubertal development in men was associated with better cognition in later adulthood in a developing Chinese population. Methods: Multivariable linear regression was used in cross-sectional study of 2463 older, Chinese men from the Guangzhou Biobank Cohort Study. Mean pubertal age was calculated as the mean of recalled ages of first nocturnal emission, voice breaking and pubarche. We assessed the association of mean pubertal age with delayed 10-word recall and mini-mental state examination (MMSE) scores. Results: Adjusted for age and education, 1 year earlier mean pubertal age was associated with higher delayed 10-word recall (0.06 [95% confidence interval = 0.02-0.10]) and higher MMSE (0.08 [0.03-0.13]) scores. Additional adjustment for childhood and adulthood socio-economic position, sitting height, and leg length did not change the results. Conclusions: These preliminary findings suggest earlier maturation in men is associated with better cognitive function in later adulthood. Whether pubertal timing is a marker of earlier life exposures or reflects a biological relation between somatrophic and/or gonadotrophic hormones and cognitive development is unclear. © 2010 Elsevier Inc. | ||||||||||
Persistent Identifier | http://hdl.handle.net/10722/129459 | ||||||||||
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 1.382 | ||||||||||
ISI Accession Number ID |
Funding Information: We thank R. Peto and Z.M. Chen of the Clinical Trial Service Unit, The University of Oxford for their support. The Guangzhou Cohort Study investigators include: Guangzhou No. 12 Hospital: X.Q. Lao, W.S. Zhang, M. Cao, T. Zhu, B. Liu, C.Q. Jiang (Co-PI); The University of Hong Kong: C.M. Schooling, S.M. McGhee, G.M. Leung, R.F. Fielding, T.H. Lam (Co-PI); The University of Birmingham: P. Adab, G.N. Thomas, Y. Peng, K.K. Cheng (Co-PI). This work was supported by the University of Hong Kong Foundation for Development and Research, Hong Kong; the University of Hong Kong University Research Committee Strategic Research Theme Public Health, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and the University of Birmingham, Birmingham, UK. | ||||||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Heys, M | en_HK |
dc.contributor.author | Jiang, C | en_HK |
dc.contributor.author | Cheng, KK | en_HK |
dc.contributor.author | Zhang, W | en_HK |
dc.contributor.author | Lam, TH | en_HK |
dc.contributor.author | Leung, GM | en_HK |
dc.contributor.author | Schooling, CM | en_HK |
dc.date.accessioned | 2010-12-23T08:37:37Z | - |
dc.date.available | 2010-12-23T08:37:37Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Annals Of Epidemiology, 2010, v. 20 n. 12, p. 948-954 | en_HK |
dc.identifier.issn | 1047-2797 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/129459 | - |
dc.description.abstract | Purpose: Earlier pubertal maturation in women may be associated with better cognition. It is unclear whether or not this also occurs in men. We tested the hypothesis that earlier pubertal development in men was associated with better cognition in later adulthood in a developing Chinese population. Methods: Multivariable linear regression was used in cross-sectional study of 2463 older, Chinese men from the Guangzhou Biobank Cohort Study. Mean pubertal age was calculated as the mean of recalled ages of first nocturnal emission, voice breaking and pubarche. We assessed the association of mean pubertal age with delayed 10-word recall and mini-mental state examination (MMSE) scores. Results: Adjusted for age and education, 1 year earlier mean pubertal age was associated with higher delayed 10-word recall (0.06 [95% confidence interval = 0.02-0.10]) and higher MMSE (0.08 [0.03-0.13]) scores. Additional adjustment for childhood and adulthood socio-economic position, sitting height, and leg length did not change the results. Conclusions: These preliminary findings suggest earlier maturation in men is associated with better cognitive function in later adulthood. Whether pubertal timing is a marker of earlier life exposures or reflects a biological relation between somatrophic and/or gonadotrophic hormones and cognitive development is unclear. © 2010 Elsevier Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/annepidem | en_HK |
dc.relation.ispartof | Annals of Epidemiology | en_HK |
dc.subject | Cognition | en_HK |
dc.subject | Epidemiology | en_HK |
dc.subject | Puberty | en_HK |
dc.subject.mesh | Adolescent Development - physiology | - |
dc.subject.mesh | Analysis of Variance | - |
dc.subject.mesh | Child Development - physiology | - |
dc.subject.mesh | Cognition - physiology | - |
dc.subject.mesh | Puberty - physiology | - |
dc.title | Does the age of achieving pubertal landmarks predict cognition in older men? Guangzhou biobank cohort study | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Heys, M: m_heys@lycos.com | en_HK |
dc.identifier.email | Lam, TH: hrmrlth@hkucc.hku.hk | en_HK |
dc.identifier.email | Leung, GM: gmleung@hku.hk | en_HK |
dc.identifier.email | Schooling, CM: cms1@hkucc.hku.hk | en_HK |
dc.identifier.authority | Heys, M=rp00257 | en_HK |
dc.identifier.authority | Lam, TH=rp00326 | en_HK |
dc.identifier.authority | Leung, GM=rp00460 | en_HK |
dc.identifier.authority | Schooling, CM=rp00504 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.annepidem.2010.06.011 | en_HK |
dc.identifier.pmid | 20727786 | - |
dc.identifier.scopus | eid_2-s2.0-78149463269 | en_HK |
dc.identifier.hkuros | 183420 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-78149463269&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 20 | en_HK |
dc.identifier.issue | 12 | en_HK |
dc.identifier.spage | 948 | en_HK |
dc.identifier.epage | 954 | en_HK |
dc.identifier.isi | WOS:000284669000010 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Heys, M=22234232400 | en_HK |
dc.identifier.scopusauthorid | Jiang, C=10639500500 | en_HK |
dc.identifier.scopusauthorid | Cheng, KK=7402997800 | en_HK |
dc.identifier.scopusauthorid | Zhang, W=14833531400 | en_HK |
dc.identifier.scopusauthorid | Lam, TH=7202522876 | en_HK |
dc.identifier.scopusauthorid | Leung, GM=7007159841 | en_HK |
dc.identifier.scopusauthorid | Schooling, CM=12808565000 | en_HK |
dc.identifier.citeulike | 7817718 | - |
dc.identifier.issnl | 1047-2797 | - |