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Article: Liver transplantation for hepatocellular carcinoma: The Hong Kong experience

TitleLiver transplantation for hepatocellular carcinoma: The Hong Kong experience
Authors
KeywordsCarcinoma
Hepatocellular
Liver
Transplantation
Issue Date2010
PublisherSpringer Japan KK. The Journal's web site is located at http://www.springer.com/medicine/surgery/journal/534
Citation
Journal Of Hepato-Biliary-Pancreatic Sciences, 2010, v. 17 n. 5, p. 548-554 How to Cite?
AbstractOrthotopic liver transplantation (OLT) is the best treatment option for selected patients with hepatocellular carcinoma (HCC) with the background of cirrhosis since this treatment modality can cure both diseases at once. Over the years, the applicability of OLT for HCC has evolved. In Asia, including Hong Kong, a shortage of deceased donor liver grafts is a universal problem having to be faced in all transplant centers. Living-donor liver transplant (LDLT) has therefore been developed to counteract organ shortage and the high prevalence of HCC. The application of LDLT for HCC is a complex process involving donor voluntarism, selection criteria for the recipient and justification with respect to long-term survival in comparison to the result of deceased donor liver transplant. This article reviews the authors' experience with OLT for HCC patients in Hong Kong, with emphasis on the applicability and outcome of LDLT for HCC. Donor voluntarismhas a significant impact on the application of LDLT. "Fast-track" LDLT in the setting of recurrence following curative treatment carries a high risk of recurrence even though the tumor stage fulfills the standard criteria. Although the survival outcome may be worse following LDLT than DDLT for HCC, LDLT is still the main treatment option for patients with transplantable HCC in Hong Kong, and a reasonable survival outcome can be achieved in selected patients with extended indications. It is particularly true that LDLT provides the only hope for patients with advanced HCC under the constricting problem of organ shortage. © Japanese Society of Hepato-Biliary-Pancreatic Surgery and Springer 2009.
Persistent Identifierhttp://hdl.handle.net/10722/129390
ISSN
2015 Impact Factor: 3.146
2015 SCImago Journal Rankings: 1.446
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, KKen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorChan, SCen_HK
dc.contributor.authorChok, KSHen_HK
dc.contributor.authorCheung, TTen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-12-23T08:36:40Z-
dc.date.available2010-12-23T08:36:40Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Hepato-Biliary-Pancreatic Sciences, 2010, v. 17 n. 5, p. 548-554en_HK
dc.identifier.issn1868-6974en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129390-
dc.description.abstractOrthotopic liver transplantation (OLT) is the best treatment option for selected patients with hepatocellular carcinoma (HCC) with the background of cirrhosis since this treatment modality can cure both diseases at once. Over the years, the applicability of OLT for HCC has evolved. In Asia, including Hong Kong, a shortage of deceased donor liver grafts is a universal problem having to be faced in all transplant centers. Living-donor liver transplant (LDLT) has therefore been developed to counteract organ shortage and the high prevalence of HCC. The application of LDLT for HCC is a complex process involving donor voluntarism, selection criteria for the recipient and justification with respect to long-term survival in comparison to the result of deceased donor liver transplant. This article reviews the authors' experience with OLT for HCC patients in Hong Kong, with emphasis on the applicability and outcome of LDLT for HCC. Donor voluntarismhas a significant impact on the application of LDLT. "Fast-track" LDLT in the setting of recurrence following curative treatment carries a high risk of recurrence even though the tumor stage fulfills the standard criteria. Although the survival outcome may be worse following LDLT than DDLT for HCC, LDLT is still the main treatment option for patients with transplantable HCC in Hong Kong, and a reasonable survival outcome can be achieved in selected patients with extended indications. It is particularly true that LDLT provides the only hope for patients with advanced HCC under the constricting problem of organ shortage. © Japanese Society of Hepato-Biliary-Pancreatic Surgery and Springer 2009.en_HK
dc.languageengen_US
dc.publisherSpringer Japan KK. The Journal's web site is located at http://www.springer.com/medicine/surgery/journal/534en_HK
dc.relation.ispartofJournal of Hepato-Biliary-Pancreatic Sciencesen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectCarcinomaen_HK
dc.subjectHepatocellularen_HK
dc.subjectLiveren_HK
dc.subjectTransplantationen_HK
dc.subject.meshCarcinoma, Hepatocellular - epidemiology - surgery-
dc.subject.meshHong Kong - epidemiology-
dc.subject.meshHumans-
dc.subject.meshLiver Neoplasms - epidemiology - surgery-
dc.subject.meshLiver Transplantation - statistics and numerical data-
dc.titleLiver transplantation for hepatocellular carcinoma: The Hong Kong experienceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1868-6974&volume=17&issue=5&spage=548&epage=554&date=2010&atitle=Liver+transplantation+for+hepatocellular+carcinoma:+the+Hong+Kong+experience-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityChan, SC=rp01568en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00534-009-0165-8en_HK
dc.identifier.pmid19760139-
dc.identifier.scopuseid_2-s2.0-79952112698en_HK
dc.identifier.hkuros183295en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952112698&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue5en_HK
dc.identifier.spage548en_HK
dc.identifier.epage554en_HK
dc.identifier.isiWOS:000280845100004-
dc.publisher.placeJapanen_HK
dc.identifier.scopusauthoridNg, KK=7403179075en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.scopusauthoridChan, SC=7404255575en_HK
dc.identifier.scopusauthoridChok, KS=6508229426en_HK
dc.identifier.scopusauthoridCheung, TT=7103334165en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.citeulike5816493-

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