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Article: Schizophrenic patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-positive network

TitleSchizophrenic patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-positive network
Authors
KeywordsSchizophrenia
Unaffected sibling
Default mode network
Functional connectivity
Resting-state
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
Citation
Schizophrenia Bulletin, 2012, v. 38 n. 2, p. 285-294 How to Cite?
Abstract
Background: Abnormal connectivity of the anticorrelated intrinsic networks, the task-negative network (TNN), and the task-positive network (TPN) is implicated in schizophrenia. Comparisons between schizophrenic patients and their unaffected siblings enable further understanding of illness susceptibility and pathophysiology. We examined the resting-state connectivity differences in the intrinsic networks between schizophrenic patients, their unaffected siblings, and healthy controls. Methods: Resting-state functional magnetic resonance images were obtained from 25 individuals in each subject group. The posterior cingulate cortex/precuneus and right dorsolateral prefrontal cortex were used as seed regions to identify the TNN and TPN through functional connectivity analysis. Interregional connectivity strengths were analyzed using overlapped intrinsic networks composed of regions common to all subject groups. Results: Schizophrenic patients and their unaffected siblings showed increased connectivity in the TNN between the bilateral inferior temporal gyri. By contrast, schizophrenic patients alone demonstrated increased connectivity between the posterior cingulate cortex/precuneus and left inferior temporal gyrus and between the ventral medial prefrontal cortex and right lateral parietal cortex in the TNN. Schizophrenic patients exhibited increased connectivity between the left dorsolateral prefrontal cortex and right inferior frontal gyrus in the TPN relative to their unaffected siblings, though this trend only approached statistical significance in comparison to healthy controls. Conclusion: Resting-state hyperconnectivity of the intrinsic networks may disrupt network coordination and thereby contribute to the pathophysiology of schizophrenia. Similar, though milder, hyperconnectivity of the TNN in unaffected siblings of schizophrenic patients may contribute to the identification of schizophrenia endophenotypes and ultimately to the determination of schizophrenia risk genes.
Persistent Identifierhttp://hdl.handle.net/10722/129353
ISSN
2013 Impact Factor: 8.607
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30670752
30900487
National Basic Research Program of China2006CB500808
2007CB512300
11th Five Year Key Program for Science and Technology Development of China2007BAI17B05
Funding Information:

National Natural Science Foundation of China (30670752 to Z.L. and 30900487 to Y.Z.); National Basic Research Program of China (2006CB500808, 2007CB512300); 11th Five Year Key Program for Science and Technology Development of China (2007BAI17B05).

 

Author Affiliations
  1. Second Xiangya Hospital of Central-South University
  2. The University of Hong Kong
  3. Institute of Automation Chinese Academy of Sciences
  4. Yale University
  5. Institute of Psychology Chinese Academy of Sciences
  6. Xiangya Hospital of Central-south University
DC FieldValueLanguage
dc.contributor.authorLiu, Hen_US
dc.contributor.authorKaneko, Yen_US
dc.contributor.authorOuyang, Xen_US
dc.contributor.authorLi, Len_US
dc.contributor.authorHao, Yen_US
dc.contributor.authorChen, EYHen_US
dc.contributor.authorJiang, Ten_US
dc.contributor.authorZhou, Yen_US
dc.contributor.authorLiu, Zen_US
dc.date.accessioned2010-12-23T08:35:51Z-
dc.date.available2010-12-23T08:35:51Z-
dc.date.issued2012en_US
dc.identifier.citationSchizophrenia Bulletin, 2012, v. 38 n. 2, p. 285-294en_US
dc.identifier.issn0586-7614-
dc.identifier.urihttp://hdl.handle.net/10722/129353-
dc.description.abstractBackground: Abnormal connectivity of the anticorrelated intrinsic networks, the task-negative network (TNN), and the task-positive network (TPN) is implicated in schizophrenia. Comparisons between schizophrenic patients and their unaffected siblings enable further understanding of illness susceptibility and pathophysiology. We examined the resting-state connectivity differences in the intrinsic networks between schizophrenic patients, their unaffected siblings, and healthy controls. Methods: Resting-state functional magnetic resonance images were obtained from 25 individuals in each subject group. The posterior cingulate cortex/precuneus and right dorsolateral prefrontal cortex were used as seed regions to identify the TNN and TPN through functional connectivity analysis. Interregional connectivity strengths were analyzed using overlapped intrinsic networks composed of regions common to all subject groups. Results: Schizophrenic patients and their unaffected siblings showed increased connectivity in the TNN between the bilateral inferior temporal gyri. By contrast, schizophrenic patients alone demonstrated increased connectivity between the posterior cingulate cortex/precuneus and left inferior temporal gyrus and between the ventral medial prefrontal cortex and right lateral parietal cortex in the TNN. Schizophrenic patients exhibited increased connectivity between the left dorsolateral prefrontal cortex and right inferior frontal gyrus in the TPN relative to their unaffected siblings, though this trend only approached statistical significance in comparison to healthy controls. Conclusion: Resting-state hyperconnectivity of the intrinsic networks may disrupt network coordination and thereby contribute to the pathophysiology of schizophrenia. Similar, though milder, hyperconnectivity of the TNN in unaffected siblings of schizophrenic patients may contribute to the identification of schizophrenia endophenotypes and ultimately to the determination of schizophrenia risk genes.-
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/-
dc.relation.ispartofSchizophrenia Bulletinen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Schizophrenia Bulletin following peer review. The definitive publisher-authenticated version Schizophrenia Bulletin, 2012, v. 38 n. 2, p. 285-294 is available online at: http://schizophreniabulletin.oxfordjournals.org/content/38/2/285-
dc.subjectSchizophrenia-
dc.subjectUnaffected sibling-
dc.subjectDefault mode network-
dc.subjectFunctional connectivity-
dc.subjectResting-state-
dc.titleSchizophrenic patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-positive networken_US
dc.typeArticleen_US
dc.identifier.emailChen, EYH: eyhchen@hku.hken_US
dc.identifier.emailLiu, Z: zningl@163.com-
dc.identifier.authorityChen, EYH=rp00392en_US
dc.description.naturepostprint-
dc.identifier.doi10.1093/schbul/sbq074-
dc.identifier.pmid20595202-
dc.identifier.pmcidPMC3283150-
dc.identifier.scopuseid_2-s2.0-84863244364-
dc.identifier.hkuros188029en_US
dc.identifier.hkuros177479-
dc.identifier.volume38-
dc.identifier.issue2-
dc.identifier.spage285-
dc.identifier.epage294-
dc.identifier.isiWOS:000300731100016-
dc.publisher.placeUnited Kingdom-

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