Article: Schizophrenic patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-positive network

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TitleSchizophrenic patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-positive network
AuthorsLiu, H4
Kaneko, Y2
Ouyang, X4
Li, L4
Hao, Y4
Chen, EYH1
Jiang, T3
Zhou, Y3
Liu, Z4
KeywordsSchizophrenia
Unaffected sibling
Default mode network
Functional connectivity
Resting-state
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
CitationSchizophrenia Bulletin, 2012, v. 38 n. 2, p. 285-294 [How to Cite?]
DOI: http://dx.doi.org/10.1093/schbul/sbq074
AbstractBackground: Abnormal connectivity of the anticorrelated intrinsic networks, the task-negative network (TNN), and the task-positive network (TPN) is implicated in schizophrenia. Comparisons between schizophrenic patients and their unaffected siblings enable further understanding of illness susceptibility and pathophysiology. We examined the resting-state connectivity differences in the intrinsic networks between schizophrenic patients, their unaffected siblings, and healthy controls. Methods: Resting-state functional magnetic resonance images were obtained from 25 individuals in each subject group. The posterior cingulate cortex/precuneus and right dorsolateral prefrontal cortex were used as seed regions to identify the TNN and TPN through functional connectivity analysis. Interregional connectivity strengths were analyzed using overlapped intrinsic networks composed of regions common to all subject groups. Results: Schizophrenic patients and their unaffected siblings showed increased connectivity in the TNN between the bilateral inferior temporal gyri. By contrast, schizophrenic patients alone demonstrated increased connectivity between the posterior cingulate cortex/precuneus and left inferior temporal gyrus and between the ventral medial prefrontal cortex and right lateral parietal cortex in the TNN. Schizophrenic patients exhibited increased connectivity between the left dorsolateral prefrontal cortex and right inferior frontal gyrus in the TPN relative to their unaffected siblings, though this trend only approached statistical significance in comparison to healthy controls. Conclusion: Resting-state hyperconnectivity of the intrinsic networks may disrupt network coordination and thereby contribute to the pathophysiology of schizophrenia. Similar, though milder, hyperconnectivity of the TNN in unaffected siblings of schizophrenic patients may contribute to the identification of schizophrenia endophenotypes and ultimately to the determination of schizophrenia risk genes.
ISSN0586-7614
2011 Impact Factor: 8.8
2011 SCImago Journal Rankings: 0.444
DOIhttp://dx.doi.org/10.1093/schbul/sbq074
ISI Accession Number IDWOS:000300731100016
Funding AgencyGrant Number
National Natural Science Foundation of China30670752
30900487
National Basic Research Program of China2006CB500808
2007CB512300
11th Five Year Key Program for Science and Technology Development of China2007BAI17B05
Funding Information:

National Natural Science Foundation of China (30670752 to Z.L. and 30900487 to Y.Z.); National Basic Research Program of China (2006CB500808, 2007CB512300); 11th Five Year Key Program for Science and Technology Development of China (2007BAI17B05).

PubMed Central IDPMC3283150
DC Field
Value
dc.contributor.authorLiu, H
dc.contributor.authorKaneko, Y
dc.contributor.authorOuyang, X
dc.contributor.authorLi, L
dc.contributor.authorHao, Y
dc.contributor.authorChen, EYH
dc.contributor.authorJiang, T
dc.contributor.authorZhou, Y
dc.contributor.authorLiu, Z
dc.date.accessioned2010-12-23T08:35:51Z
dc.date.available2010-12-23T08:35:51Z
dc.date.issued2012
dc.description.abstractBackground: Abnormal connectivity of the anticorrelated intrinsic networks, the task-negative network (TNN), and the task-positive network (TPN) is implicated in schizophrenia. Comparisons between schizophrenic patients and their unaffected siblings enable further understanding of illness susceptibility and pathophysiology. We examined the resting-state connectivity differences in the intrinsic networks between schizophrenic patients, their unaffected siblings, and healthy controls. Methods: Resting-state functional magnetic resonance images were obtained from 25 individuals in each subject group. The posterior cingulate cortex/precuneus and right dorsolateral prefrontal cortex were used as seed regions to identify the TNN and TPN through functional connectivity analysis. Interregional connectivity strengths were analyzed using overlapped intrinsic networks composed of regions common to all subject groups. Results: Schizophrenic patients and their unaffected siblings showed increased connectivity in the TNN between the bilateral inferior temporal gyri. By contrast, schizophrenic patients alone demonstrated increased connectivity between the posterior cingulate cortex/precuneus and left inferior temporal gyrus and between the ventral medial prefrontal cortex and right lateral parietal cortex in the TNN. Schizophrenic patients exhibited increased connectivity between the left dorsolateral prefrontal cortex and right inferior frontal gyrus in the TPN relative to their unaffected siblings, though this trend only approached statistical significance in comparison to healthy controls. Conclusion: Resting-state hyperconnectivity of the intrinsic networks may disrupt network coordination and thereby contribute to the pathophysiology of schizophrenia. Similar, though milder, hyperconnectivity of the TNN in unaffected siblings of schizophrenic patients may contribute to the identification of schizophrenia endophenotypes and ultimately to the determination of schizophrenia risk genes.
dc.description.naturepostprint
dc.identifier.citationSchizophrenia Bulletin, 2012, v. 38 n. 2, p. 285-294 [How to Cite?]
DOI: http://dx.doi.org/10.1093/schbul/sbq074
dc.identifier.doihttp://dx.doi.org/10.1093/schbul/sbq074
dc.identifier.epage294
dc.identifier.hkuros188029
dc.identifier.hkuros177479
dc.identifier.isiWOS:000300731100016
Funding AgencyGrant Number
National Natural Science Foundation of China30670752
30900487
National Basic Research Program of China2006CB500808
2007CB512300
11th Five Year Key Program for Science and Technology Development of China2007BAI17B05
Funding Information:

National Natural Science Foundation of China (30670752 to Z.L. and 30900487 to Y.Z.); National Basic Research Program of China (2006CB500808, 2007CB512300); 11th Five Year Key Program for Science and Technology Development of China (2007BAI17B05).

dc.identifier.issn0586-7614
2011 Impact Factor: 8.8
2011 SCImago Journal Rankings: 0.444
dc.identifier.issue2
dc.identifier.pmcidPMC3283150
dc.identifier.pmid20595202
dc.identifier.scopuseid_2-s2.0-84863244364
dc.identifier.spage285
dc.identifier.urihttp://hdl.handle.net/10722/129353
dc.identifier.volume38
dc.languageeng
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofSchizophrenia Bulletin
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Schizophrenia Bulletin following peer review. The definitive publisher-authenticated version Schizophrenia Bulletin, 2012, v. 38 n. 2, p. 285-294 is available online at: http://schizophreniabulletin.oxfordjournals.org/content/38/2/285
dc.subjectSchizophrenia
dc.subjectUnaffected sibling
dc.subjectDefault mode network
dc.subjectFunctional connectivity
dc.subjectResting-state
dc.titleSchizophrenic patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-positive network
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Yale University
  3. Chinese Academy of Sciences
  4. Central South University China