File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Guillain-Barre syndrome in southern Chinese children: 32 year experience in Hong Kong

TitleGuillain-Barre syndrome in southern Chinese children: 32 year experience in Hong Kong
Authors
KeywordsAcute inflammatory demyelinating polyradiculoneuropathy
Children
Chinese
Guillain-Barre syndrome
Immunoglobulin
Issue Date2010
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PED
Citation
Pediatrics International, 2010, v. 52 n. 1, p. 13-19 How to Cite?
AbstractBackground: The purpose of the present study was to investigate the clinical pattern of Guillain-Barre syndrome (GBS) in southern Chinese children in Hong Kong and to compare the clinical outcome of early versus delayed intervention with i.v. immunoglobulin (IVIg). Methods: A retrospective review of medical records of GBS patients admitted to two hospitals on Hong Kong Island during a 32 year period (1976-2008) was performed. Clinical outcome was compared for early versus late IVIg treatment, using a 7 day cut-off. This analysis was then repeated using a 10 day cut-off. Results: Of 34 children, 22 (65%) had preceding illness but no infective etiology could be identified. Nerve conduction was measured in 17 (50%): nine had demyelinating neuropathy, three had axonal neuropathy with demyelinating features, two had pure axonal neuropathy, and one was normal. In two patients with Miller-Fisher syndrome (MFS) the studies showed additional abnormal sensory conduction. Twenty-one received conservative treatment only. Ten (29%) received IVIg, two (6%) received plasmapheresis and three (9%) received corticosteroid. Thirty-one (91%) had complete recovery, two (6%) had long-term morbidity and one died of respiratory failure. Comparison of the early and late IVIg treatment groups for each cut-off showed no statistically significant difference in clinical outcome. A longer period of hospital stay and longer time to improve one disability grade, however, were noted for the late treatment group for both cut-offs. Conclusions: The clinical profile of GBS in southern Chinese children in Hong Kong is provided. There was no statistically significant difference between early versus delayed treatment with IVIg. © 2010 Japan Pediatric Society.
Persistent Identifierhttp://hdl.handle.net/10722/129319
ISSN
2015 Impact Factor: 0.868
2015 SCImago Journal Rankings: 0.424
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, YMen_HK
dc.contributor.authorLiu, TKTen_HK
dc.contributor.authorWong, Ven_HK
dc.date.accessioned2010-12-23T08:35:17Z-
dc.date.available2010-12-23T08:35:17Z-
dc.date.issued2010en_HK
dc.identifier.citationPediatrics International, 2010, v. 52 n. 1, p. 13-19en_HK
dc.identifier.issn1328-8067en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129319-
dc.description.abstractBackground: The purpose of the present study was to investigate the clinical pattern of Guillain-Barre syndrome (GBS) in southern Chinese children in Hong Kong and to compare the clinical outcome of early versus delayed intervention with i.v. immunoglobulin (IVIg). Methods: A retrospective review of medical records of GBS patients admitted to two hospitals on Hong Kong Island during a 32 year period (1976-2008) was performed. Clinical outcome was compared for early versus late IVIg treatment, using a 7 day cut-off. This analysis was then repeated using a 10 day cut-off. Results: Of 34 children, 22 (65%) had preceding illness but no infective etiology could be identified. Nerve conduction was measured in 17 (50%): nine had demyelinating neuropathy, three had axonal neuropathy with demyelinating features, two had pure axonal neuropathy, and one was normal. In two patients with Miller-Fisher syndrome (MFS) the studies showed additional abnormal sensory conduction. Twenty-one received conservative treatment only. Ten (29%) received IVIg, two (6%) received plasmapheresis and three (9%) received corticosteroid. Thirty-one (91%) had complete recovery, two (6%) had long-term morbidity and one died of respiratory failure. Comparison of the early and late IVIg treatment groups for each cut-off showed no statistically significant difference in clinical outcome. A longer period of hospital stay and longer time to improve one disability grade, however, were noted for the late treatment group for both cut-offs. Conclusions: The clinical profile of GBS in southern Chinese children in Hong Kong is provided. There was no statistically significant difference between early versus delayed treatment with IVIg. © 2010 Japan Pediatric Society.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PEDen_HK
dc.relation.ispartofPediatrics Internationalen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectAcute inflammatory demyelinating polyradiculoneuropathyen_HK
dc.subjectChildrenen_HK
dc.subjectChineseen_HK
dc.subjectGuillain-Barre syndromeen_HK
dc.subjectImmunoglobulinen_HK
dc.subject.meshAdolescent-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshCross-Cultural Comparison-
dc.subject.meshGuillain-Barre Syndrome - classification - drug therapy - epidemiology - ethnology-
dc.titleGuillain-Barre syndrome in southern Chinese children: 32 year experience in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1328-8067&volume=52&issue=1&spage=13&epage=19&date=2010&atitle=Guillain-Barre+syndrome+in+southern+Chinese+children:+32+year+experience+in+Hong+Kong-
dc.identifier.emailWong, V:vcnwong@hku.hken_HK
dc.identifier.authorityWong, V=rp00334en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1442-200X.2009.02951.xen_HK
dc.identifier.pmid19702649-
dc.identifier.scopuseid_2-s2.0-76249083589en_HK
dc.identifier.hkuros176743en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-76249083589&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue1en_HK
dc.identifier.spage13en_HK
dc.identifier.epage19en_HK
dc.identifier.isiWOS:000273998000008-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridMa, YM=16638152900en_HK
dc.identifier.scopusauthoridLiu, TKT=36087727500en_HK
dc.identifier.scopusauthoridWong, V=7202525632en_HK
dc.identifier.citeulike6843121-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats