File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The morphology and lattice structure of bone crystal after strontium treatment in goats

TitleThe morphology and lattice structure of bone crystal after strontium treatment in goats
Authors
KeywordsBone crystal
Bone quality
Goats
Osteoporosis
Strontium
Issue Date2010
PublisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00774/index.htm
Citation
Journal Of Bone And Mineral Metabolism, 2010, v. 28 n. 1, p. 25-34 How to Cite?
AbstractStrontium (Sr) compounds have become increasingly popular in osteoporosis treatment. As a bone seeking element, 98% of Sr deposits in bone and teeth after oral ingestion. However, the quality of new bone after Sr deposition is yet to be extensively investigated. In this study, eight osteopenic goats were divided into two groups: Ca + 40Sr (five goats) and controls (three goats). Controls were fed with low calcium feeds. Ca phosphate was supplied at 100 mg/(kg day), and Sr phosphate at 40 mg/(kg day) in the Ca + 40Sr group. The newly formed bone at the outer cortical area of the femur with Sr deposition was identified from tetracycline labels, and the morphology and lattice structure of the crystals in these regions were investigated. Results showed that Sr concentrations of bone tissue significantly increased 144.37% for Sr administration without significant change in Ca concentration, and the ingested Sr mainly deposited in new bone. The crystal isolated from new bone exhibited the typical character of biological apatite as determined by Fourier transform infrared spectroscopy and selected-area electron diffraction. Transmission electron microscopy examination showed that a crystal with width of 8-10 nm grew along with the (002) lattice and aligned with the same direction in both groups. The elemental analysis of crystals showed that the ingested Sr deposited mainly in the bone matrix or was absorbed on the bone crystal surface, while only a limited amount of Sr replaced Ca in apatite crystals. Our findings showed that Sr administration at current dosages for prevention and treatment of osteoporosis might not change the bone crystal morphology and structure. © 2009 The Japanese Society for Bone and Mineral Research and Springer.
Persistent Identifierhttp://hdl.handle.net/10722/129310
ISSN
2015 Impact Factor: 2.312
2015 SCImago Journal Rankings: 0.775
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong RGCHKU7147/07E
Hong Kong ITF FundGHP/009/06
Funding Information:

This study was partially supported by the Hong Kong RGC (HKU7147/07E) and Hong Kong ITF Fund GHP/009/06. The authors would like to thank Mr. Stephen Chan and Patrick Wong for their expert technical assistance in specimen preparation and Frankie Chan in EMU for TEM examination.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLi, Zen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorDeng, Len_HK
dc.contributor.authorChiu, PKYen_HK
dc.contributor.authorFang, Den_HK
dc.contributor.authorLam, RWMen_HK
dc.contributor.authorLeong, JCYen_HK
dc.contributor.authorLuk, KDKen_HK
dc.date.accessioned2010-12-23T08:35:09Z-
dc.date.available2010-12-23T08:35:09Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Bone And Mineral Metabolism, 2010, v. 28 n. 1, p. 25-34en_HK
dc.identifier.issn0914-8779en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129310-
dc.description.abstractStrontium (Sr) compounds have become increasingly popular in osteoporosis treatment. As a bone seeking element, 98% of Sr deposits in bone and teeth after oral ingestion. However, the quality of new bone after Sr deposition is yet to be extensively investigated. In this study, eight osteopenic goats were divided into two groups: Ca + 40Sr (five goats) and controls (three goats). Controls were fed with low calcium feeds. Ca phosphate was supplied at 100 mg/(kg day), and Sr phosphate at 40 mg/(kg day) in the Ca + 40Sr group. The newly formed bone at the outer cortical area of the femur with Sr deposition was identified from tetracycline labels, and the morphology and lattice structure of the crystals in these regions were investigated. Results showed that Sr concentrations of bone tissue significantly increased 144.37% for Sr administration without significant change in Ca concentration, and the ingested Sr mainly deposited in new bone. The crystal isolated from new bone exhibited the typical character of biological apatite as determined by Fourier transform infrared spectroscopy and selected-area electron diffraction. Transmission electron microscopy examination showed that a crystal with width of 8-10 nm grew along with the (002) lattice and aligned with the same direction in both groups. The elemental analysis of crystals showed that the ingested Sr deposited mainly in the bone matrix or was absorbed on the bone crystal surface, while only a limited amount of Sr replaced Ca in apatite crystals. Our findings showed that Sr administration at current dosages for prevention and treatment of osteoporosis might not change the bone crystal morphology and structure. © 2009 The Japanese Society for Bone and Mineral Research and Springer.en_HK
dc.languageengen_US
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00774/index.htmen_HK
dc.relation.ispartofJournal of Bone and Mineral Metabolismen_HK
dc.subjectBone crystalen_HK
dc.subjectBone qualityen_HK
dc.subjectGoatsen_HK
dc.subjectOsteoporosisen_HK
dc.subjectStrontiumen_HK
dc.subject.meshBone Density Conservation Agents - pharmacology - therapeutic use-
dc.subject.meshBone and Bones - chemistry - ultrastructure-
dc.subject.meshOsteogenesis - drug effects-
dc.subject.meshPhosphates - pharmacology - therapeutic use-
dc.subject.meshStrontium - analysis - pharmacology - therapeutic use-
dc.titleThe morphology and lattice structure of bone crystal after strontium treatment in goatsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0884-0431&volume=28&issue=1&spage=25&epage=34&date=2010&atitle=The+morphology+and+lattice+structure+of+bone+crystal+after+strontium+treatment+in+goats-
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.emailChiu, PKY:pkychiu@hkucc.hku.hken_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityChiu, PKY=rp00379en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00774-009-0109-zen_HK
dc.identifier.pmid19603246-
dc.identifier.scopuseid_2-s2.0-76949107493en_HK
dc.identifier.hkuros178190en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-76949107493&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue1en_HK
dc.identifier.spage25en_HK
dc.identifier.epage34en_HK
dc.identifier.isiWOS:000273033000004-
dc.publisher.placeJapanen_HK
dc.relation.projectOptimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications-
dc.identifier.scopusauthoridLi, Z=35784563200en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridDeng, L=7202007494en_HK
dc.identifier.scopusauthoridChiu, PKY=7202988127en_HK
dc.identifier.scopusauthoridFang, D=20134136000en_HK
dc.identifier.scopusauthoridLam, RWM=14625371400en_HK
dc.identifier.scopusauthoridLeong, JCY=35560782200en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.citeulike5241681-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats