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- Publisher Website: 10.3390/v2010283
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- PMID: 21994611
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Article: The development of an AIDS mucosal vaccine
Title | The development of an AIDS mucosal vaccine | ||||||||
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Authors | |||||||||
Keywords | Aids Hiv-1 Mucosal vaccination Mvtt Vaccine | ||||||||
Issue Date | 2010 | ||||||||
Publisher | Molecular Diversity Preservation International (MDPI) AG.. The Journal's web site is located at http://www.mdpi.com/journal/viruses | ||||||||
Citation | Viruses, 2010, v. 2 n. 1, p. 283-297 How to Cite? | ||||||||
Abstract | It is well known that mucosal tissues contain the largest surface area of the human body and are the front line of natural host defense against various pathogens. In fact, more than 80% of infectious disease pathogens probably gain entry into the susceptible human hosts through open mucosal surfaces. Human immunodeficiency virus type one (HIV-1), a mainly sexually transmitted virus, also primarily targets the vaginal and gastrointestinal mucosa as entry sites for viral transmission, seeding, replication and amplification. Since HIV-1 establishes its early replication in vaginal or rectal mucosal tissues, the induction of sufficient mucosal immunity at the initial site of HIV-1 transmission becomes essential for a protective vaccine. However, despite the fact that current conventional vaccine strategies have remained unsuccessful in preventing HIV-1 infection, sufficient financial support and resources have yet to be given to develop a vaccine able to elicit protective mucosal immunity against sexual transmissions. Interestingly, Chinese ancestors invented variolation through intranasal administration about one thousand years ago, which led to the discovery of a successful smallpox vaccine and the final eradication of the disease. It is the hope for all mankind that the development of a mucosal AIDS vaccine will ultimately help control the AIDS pandemic. In order to discover an effective mucosal AIDS vaccine, it is necessary to have a deep understanding of mucosal immunology and to test various mucosal vaccination strategies. © 2010 by the authors. | ||||||||
Persistent Identifier | http://hdl.handle.net/10722/129302 | ||||||||
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 1.140 | ||||||||
PubMed Central ID | |||||||||
ISI Accession Number ID |
Funding Information: The authors thank financial supports from Hong Kong research grant council (HK-RGC762208 and HK-RGC762209 to ZC), the National Science and Technology Major Programs (2008ZX10001-011 and 2008ZX10001-015) and the University Development Fund of the University of Hong Kong to its AIDS Institute. The authors also thank D.D. Ho and K.Y. Yuen for scientific advice and discussions. | ||||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tang, X | en_HK |
dc.contributor.author | Chen, Z | en_HK |
dc.date.accessioned | 2010-12-23T08:34:57Z | - |
dc.date.available | 2010-12-23T08:34:57Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Viruses, 2010, v. 2 n. 1, p. 283-297 | en_HK |
dc.identifier.issn | 1999-4915 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/129302 | - |
dc.description.abstract | It is well known that mucosal tissues contain the largest surface area of the human body and are the front line of natural host defense against various pathogens. In fact, more than 80% of infectious disease pathogens probably gain entry into the susceptible human hosts through open mucosal surfaces. Human immunodeficiency virus type one (HIV-1), a mainly sexually transmitted virus, also primarily targets the vaginal and gastrointestinal mucosa as entry sites for viral transmission, seeding, replication and amplification. Since HIV-1 establishes its early replication in vaginal or rectal mucosal tissues, the induction of sufficient mucosal immunity at the initial site of HIV-1 transmission becomes essential for a protective vaccine. However, despite the fact that current conventional vaccine strategies have remained unsuccessful in preventing HIV-1 infection, sufficient financial support and resources have yet to be given to develop a vaccine able to elicit protective mucosal immunity against sexual transmissions. Interestingly, Chinese ancestors invented variolation through intranasal administration about one thousand years ago, which led to the discovery of a successful smallpox vaccine and the final eradication of the disease. It is the hope for all mankind that the development of a mucosal AIDS vaccine will ultimately help control the AIDS pandemic. In order to discover an effective mucosal AIDS vaccine, it is necessary to have a deep understanding of mucosal immunology and to test various mucosal vaccination strategies. © 2010 by the authors. | en_HK |
dc.language | eng | en_US |
dc.publisher | Molecular Diversity Preservation International (MDPI) AG.. The Journal's web site is located at http://www.mdpi.com/journal/viruses | en_HK |
dc.relation.ispartof | Viruses | en_HK |
dc.subject | Aids | en_HK |
dc.subject | Hiv-1 | en_HK |
dc.subject | Mucosal vaccination | en_HK |
dc.subject | Mvtt | en_HK |
dc.subject | Vaccine | en_HK |
dc.title | The development of an AIDS mucosal vaccine | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1999-4915&volume=2&issue=1&spage=283&epage=297&date=2010&atitle=The+development+of+an+AIDS+mucosal+vaccine | - |
dc.identifier.email | Chen, Z:zchenai@hkucc.hku.hk | en_HK |
dc.identifier.authority | Chen, Z=rp00243 | en_HK |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/v2010283 | en_HK |
dc.identifier.pmid | 21994611 | - |
dc.identifier.pmcid | PMC3185548 | - |
dc.identifier.scopus | eid_2-s2.0-79952083300 | en_HK |
dc.identifier.hkuros | 176629 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-79952083300&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 2 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 283 | en_HK |
dc.identifier.epage | 297 | en_HK |
dc.identifier.isi | WOS:000280413300016 | - |
dc.publisher.place | Switzerland | en_HK |
dc.identifier.scopusauthorid | Tang, X=36143652700 | en_HK |
dc.identifier.scopusauthorid | Chen, Z=35271180800 | en_HK |
dc.identifier.citeulike | 6581465 | - |
dc.identifier.issnl | 1999-4915 | - |