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Article: A polymorphism in transforming growth factor-β1 is associated with carotid plaques and increased carotid intima-media thickness in older Chinese men: The Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort
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TitleA polymorphism in transforming growth factor-β1 is associated with carotid plaques and increased carotid intima-media thickness in older Chinese men: The Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort
 
AuthorsDeng, HB4
Jiang, CQ3
Tomlinson, B4
Liu, B3
Lin, JM3
Wong, KS4
Cheung, BMY1
Lam, TH1
Thomas, GN2
 
KeywordsAtherosclerosis
Carotid plaque
Intima-media thickness
TGF-β1
 
Issue Date2011
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
 
CitationAtherosclerosis, 2011, v. 214 n. 2, p. 391-396 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.atherosclerosis.2010.11.025
 
AbstractObjective: Polymorphisms of the transforming growth factor-β1 (TGFB1) gene have not been associated with asymptomatic atherosclerosis previously. We investigated the relationship between a single nucleotide polymorphism (SNP) rs4803455 in TGFB1 and atherosclerosis identified by the presence of carotid plaque and increased intima-media thickness (IMT) in an older Chinese population. Methods: 1996 subjects (992 (49.7%) men aged 50-85 years) from the Guangzhou Biobank Cohort Study-Cardiovascular Subcohort (GBCS-CVD) were genotyped. Carotid plaque and IMT were assessed by B-mode ultrasonography. Results: In male subjects, the C allele of TGFB1 rs4803455 was significantly associated with prevalence of carotid plaque (adjusted OR: 2.49, 95% CI: 1.16-5.36, P = 0.03). The C allele was related to increased number of common carotid artery (CCA) plaques (P = 0.03) and larger carotid plaque area (P = 0.02) in men. The homozygous carriers of allele C in male subjects also had a higher risk of having carotid IMT ≥1. mm (adjusted OR: 1.75, 95% CI: 1.05-2.93, P = 0.03). These associations were independent of age, smoking, physical activity, body mass index, blood pressure, lipid profile, fasting glucose and high sensitivity C-reactive protein. Conclusion: This is the first study to show that the C allele in TGFB1 was associated with increased risk of atherosclerosis in older Chinese men. Further investigations on the linkage between the TGFB1 gene and progression of atherosclerosis in asymptomatic populations are warranted. © 2010 Elsevier Ireland Ltd.
 
ISSN0021-9150
2012 Impact Factor: 3.706
2012 SCImago Journal Rankings: 1.388
 
DOIhttp://dx.doi.org/10.1016/j.atherosclerosis.2010.11.025
 
ISI Accession Number IDWOS:000286651100025
Funding AgencyGrant Number
National Natural Science Foundation of China/Research Grants Council (NSFC/RGC)30518001
HKU720/05
Funding Information:

The study is funded by National Natural Science Foundation of China/Research Grants Council (NSFC/RGC) (No. 30518001; HKU720/05) grant. The University of Hong Kong Foundation for Educational Development and Research, Hong Kong; the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau, Guangzhou, China, and The University of Birmingham, UK. The Guangzhou Biobank Cohort Study-CVD investigators include: the Guangzhou No. 12 Hospital: JM Lin, XJ Yue, CQ Jiang (Co-PI); The University of Hong Kong: TH Lam, BMY Cheung; The Chinese University of Hong Kong: B Tomlinson, KS Wong; The University of Birmingham: GN Thomas (Co-PI), KK Cheng.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorDeng, HB
 
dc.contributor.authorJiang, CQ
 
dc.contributor.authorTomlinson, B
 
dc.contributor.authorLiu, B
 
dc.contributor.authorLin, JM
 
dc.contributor.authorWong, KS
 
dc.contributor.authorCheung, BMY
 
dc.contributor.authorLam, TH
 
dc.contributor.authorThomas, GN
 
dc.date.accessioned2010-12-23T08:34:35Z
 
dc.date.available2010-12-23T08:34:35Z
 
dc.date.issued2011
 
dc.description.abstractObjective: Polymorphisms of the transforming growth factor-β1 (TGFB1) gene have not been associated with asymptomatic atherosclerosis previously. We investigated the relationship between a single nucleotide polymorphism (SNP) rs4803455 in TGFB1 and atherosclerosis identified by the presence of carotid plaque and increased intima-media thickness (IMT) in an older Chinese population. Methods: 1996 subjects (992 (49.7%) men aged 50-85 years) from the Guangzhou Biobank Cohort Study-Cardiovascular Subcohort (GBCS-CVD) were genotyped. Carotid plaque and IMT were assessed by B-mode ultrasonography. Results: In male subjects, the C allele of TGFB1 rs4803455 was significantly associated with prevalence of carotid plaque (adjusted OR: 2.49, 95% CI: 1.16-5.36, P = 0.03). The C allele was related to increased number of common carotid artery (CCA) plaques (P = 0.03) and larger carotid plaque area (P = 0.02) in men. The homozygous carriers of allele C in male subjects also had a higher risk of having carotid IMT ≥1. mm (adjusted OR: 1.75, 95% CI: 1.05-2.93, P = 0.03). These associations were independent of age, smoking, physical activity, body mass index, blood pressure, lipid profile, fasting glucose and high sensitivity C-reactive protein. Conclusion: This is the first study to show that the C allele in TGFB1 was associated with increased risk of atherosclerosis in older Chinese men. Further investigations on the linkage between the TGFB1 gene and progression of atherosclerosis in asymptomatic populations are warranted. © 2010 Elsevier Ireland Ltd.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAtherosclerosis, 2011, v. 214 n. 2, p. 391-396 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.atherosclerosis.2010.11.025
 
dc.identifier.citeulike8345904
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.atherosclerosis.2010.11.025
 
dc.identifier.epage396
 
dc.identifier.hkuros183452
 
dc.identifier.isiWOS:000286651100025
Funding AgencyGrant Number
National Natural Science Foundation of China/Research Grants Council (NSFC/RGC)30518001
HKU720/05
Funding Information:

The study is funded by National Natural Science Foundation of China/Research Grants Council (NSFC/RGC) (No. 30518001; HKU720/05) grant. The University of Hong Kong Foundation for Educational Development and Research, Hong Kong; the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau, Guangzhou, China, and The University of Birmingham, UK. The Guangzhou Biobank Cohort Study-CVD investigators include: the Guangzhou No. 12 Hospital: JM Lin, XJ Yue, CQ Jiang (Co-PI); The University of Hong Kong: TH Lam, BMY Cheung; The Chinese University of Hong Kong: B Tomlinson, KS Wong; The University of Birmingham: GN Thomas (Co-PI), KK Cheng.

 
dc.identifier.issn0021-9150
2012 Impact Factor: 3.706
2012 SCImago Journal Rankings: 1.388
 
dc.identifier.issue2
 
dc.identifier.pmid21167485
 
dc.identifier.scopuseid_2-s2.0-79151476007
 
dc.identifier.spage391
 
dc.identifier.urihttp://hdl.handle.net/10722/129275
 
dc.identifier.volume214
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
 
dc.publisher.placeIreland
 
dc.relation.ispartofAtherosclerosis
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAge Factors
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 and over
 
dc.subject.meshAsian Continental Ancestry Group - genetics
 
dc.subject.meshCarotid Arteries - ultrasonography
 
dc.subject.meshCarotid Artery Diseases - ethnology - genetics - ultrasonography
 
dc.subject.meshChi-Square Distribution
 
dc.subject.meshChina
 
dc.subject.meshFemale
 
dc.subject.meshGene Frequency
 
dc.subject.meshGenetic Predisposition to Disease
 
dc.subject.meshHomozygote
 
dc.subject.meshHumans
 
dc.subject.meshIntrons
 
dc.subject.meshLinear Models
 
dc.subject.meshLinkage Disequilibrium
 
dc.subject.meshLogistic Models
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshOdds Ratio
 
dc.subject.meshPhenotype
 
dc.subject.meshPolymorphism, Single Nucleotide
 
dc.subject.meshRisk Assessment
 
dc.subject.meshRisk Factors
 
dc.subject.meshSex Factors
 
dc.subject.meshTransforming Growth Factor beta1 - genetics
 
dc.subject.meshTunica Intima - ultrasonography
 
dc.subject.meshTunica Media - ultrasonography
 
dc.subjectAtherosclerosis
 
dc.subjectCarotid plaque
 
dc.subjectIntima-media thickness
 
dc.subjectTGF-β1
 
dc.titleA polymorphism in transforming growth factor-β1 is associated with carotid plaques and increased carotid intima-media thickness in older Chinese men: The Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort
 
dc.typeArticle
 
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<contributor.author>Tomlinson, B</contributor.author>
<contributor.author>Liu, B</contributor.author>
<contributor.author>Lin, JM</contributor.author>
<contributor.author>Wong, KS</contributor.author>
<contributor.author>Cheung, BMY</contributor.author>
<contributor.author>Lam, TH</contributor.author>
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<description.abstract>Objective: Polymorphisms of the transforming growth factor-&#946;1 (TGFB1) gene have not been associated with asymptomatic atherosclerosis previously. We investigated the relationship between a single nucleotide polymorphism (SNP) rs4803455 in TGFB1 and atherosclerosis identified by the presence of carotid plaque and increased intima-media thickness (IMT) in an older Chinese population. Methods: 1996 subjects (992 (49.7%) men aged 50-85 years) from the Guangzhou Biobank Cohort Study-Cardiovascular Subcohort (GBCS-CVD) were genotyped. Carotid plaque and IMT were assessed by B-mode ultrasonography. Results: In male subjects, the C allele of TGFB1 rs4803455 was significantly associated with prevalence of carotid plaque (adjusted OR: 2.49, 95% CI: 1.16-5.36, P = 0.03). The C allele was related to increased number of common carotid artery (CCA) plaques (P = 0.03) and larger carotid plaque area (P = 0.02) in men. The homozygous carriers of allele C in male subjects also had a higher risk of having carotid IMT &#8805;1. mm (adjusted OR: 1.75, 95% CI: 1.05-2.93, P = 0.03). These associations were independent of age, smoking, physical activity, body mass index, blood pressure, lipid profile, fasting glucose and high sensitivity C-reactive protein. Conclusion: This is the first study to show that the C allele in TGFB1 was associated with increased risk of atherosclerosis in older Chinese men. Further investigations on the linkage between the TGFB1 gene and progression of atherosclerosis in asymptomatic populations are warranted. &#169; 2010 Elsevier Ireland Ltd.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. University of Birmingham
  3. Guangzhou No. 12 Hospital
  4. Chinese University of Hong Kong