Article: A polymorphism in transforming growth factor-β1 is associated with carotid plaques and increased carotid intima-media thickness in older Chinese men: The Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort

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TitleA polymorphism in transforming growth factor-β1 is associated with carotid plaques and increased carotid intima-media thickness in older Chinese men: The Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort
AuthorsDeng, HB4
Jiang, CQ3
Tomlinson, B4
Liu, B3
Lin, JM3
Wong, KS4
Cheung, BMY1
Lam, TH1
Thomas, GN2
KeywordsAtherosclerosis
Carotid plaque
Intima-media thickness
TGF-β1
Issue Date2011
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
CitationAtherosclerosis, 2011, v. 214 n. 2, p. 391-396 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.atherosclerosis.2010.11.025
AbstractObjective: Polymorphisms of the transforming growth factor-β1 (TGFB1) gene have not been associated with asymptomatic atherosclerosis previously. We investigated the relationship between a single nucleotide polymorphism (SNP) rs4803455 in TGFB1 and atherosclerosis identified by the presence of carotid plaque and increased intima-media thickness (IMT) in an older Chinese population. Methods: 1996 subjects (992 (49.7%) men aged 50-85 years) from the Guangzhou Biobank Cohort Study-Cardiovascular Subcohort (GBCS-CVD) were genotyped. Carotid plaque and IMT were assessed by B-mode ultrasonography. Results: In male subjects, the C allele of TGFB1 rs4803455 was significantly associated with prevalence of carotid plaque (adjusted OR: 2.49, 95% CI: 1.16-5.36, P = 0.03). The C allele was related to increased number of common carotid artery (CCA) plaques (P = 0.03) and larger carotid plaque area (P = 0.02) in men. The homozygous carriers of allele C in male subjects also had a higher risk of having carotid IMT ≥1. mm (adjusted OR: 1.75, 95% CI: 1.05-2.93, P = 0.03). These associations were independent of age, smoking, physical activity, body mass index, blood pressure, lipid profile, fasting glucose and high sensitivity C-reactive protein. Conclusion: This is the first study to show that the C allele in TGFB1 was associated with increased risk of atherosclerosis in older Chinese men. Further investigations on the linkage between the TGFB1 gene and progression of atherosclerosis in asymptomatic populations are warranted. © 2010 Elsevier Ireland Ltd.
ISSN0021-9150
2011 Impact Factor: 3.794
2011 SCImago Journal Rankings: 0.372
DOIhttp://dx.doi.org/10.1016/j.atherosclerosis.2010.11.025
ISI Accession Number IDWOS:000286651100025
Funding AgencyGrant Number
National Natural Science Foundation of China/Research Grants Council (NSFC/RGC)30518001
HKU720/05
Funding Information:

The study is funded by National Natural Science Foundation of China/Research Grants Council (NSFC/RGC) (No. 30518001; HKU720/05) grant. The University of Hong Kong Foundation for Educational Development and Research, Hong Kong; the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau, Guangzhou, China, and The University of Birmingham, UK. The Guangzhou Biobank Cohort Study-CVD investigators include: the Guangzhou No. 12 Hospital: JM Lin, XJ Yue, CQ Jiang (Co-PI); The University of Hong Kong: TH Lam, BMY Cheung; The Chinese University of Hong Kong: B Tomlinson, KS Wong; The University of Birmingham: GN Thomas (Co-PI), KK Cheng.

ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorDeng, HB
dc.contributor.authorJiang, CQ
dc.contributor.authorTomlinson, B
dc.contributor.authorLiu, B
dc.contributor.authorLin, JM
dc.contributor.authorWong, KS
dc.contributor.authorCheung, BMY
dc.contributor.authorLam, TH
dc.contributor.authorThomas, GN
dc.date.accessioned2010-12-23T08:34:35Z
dc.date.available2010-12-23T08:34:35Z
dc.date.issued2011
dc.description.abstractObjective: Polymorphisms of the transforming growth factor-β1 (TGFB1) gene have not been associated with asymptomatic atherosclerosis previously. We investigated the relationship between a single nucleotide polymorphism (SNP) rs4803455 in TGFB1 and atherosclerosis identified by the presence of carotid plaque and increased intima-media thickness (IMT) in an older Chinese population. Methods: 1996 subjects (992 (49.7%) men aged 50-85 years) from the Guangzhou Biobank Cohort Study-Cardiovascular Subcohort (GBCS-CVD) were genotyped. Carotid plaque and IMT were assessed by B-mode ultrasonography. Results: In male subjects, the C allele of TGFB1 rs4803455 was significantly associated with prevalence of carotid plaque (adjusted OR: 2.49, 95% CI: 1.16-5.36, P = 0.03). The C allele was related to increased number of common carotid artery (CCA) plaques (P = 0.03) and larger carotid plaque area (P = 0.02) in men. The homozygous carriers of allele C in male subjects also had a higher risk of having carotid IMT ≥1. mm (adjusted OR: 1.75, 95% CI: 1.05-2.93, P = 0.03). These associations were independent of age, smoking, physical activity, body mass index, blood pressure, lipid profile, fasting glucose and high sensitivity C-reactive protein. Conclusion: This is the first study to show that the C allele in TGFB1 was associated with increased risk of atherosclerosis in older Chinese men. Further investigations on the linkage between the TGFB1 gene and progression of atherosclerosis in asymptomatic populations are warranted. © 2010 Elsevier Ireland Ltd.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAtherosclerosis, 2011, v. 214 n. 2, p. 391-396 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.atherosclerosis.2010.11.025
dc.identifier.citeulike8345904
dc.identifier.doihttp://dx.doi.org/10.1016/j.atherosclerosis.2010.11.025
dc.identifier.epage396
dc.identifier.hkuros183452
dc.identifier.isiWOS:000286651100025
Funding AgencyGrant Number
National Natural Science Foundation of China/Research Grants Council (NSFC/RGC)30518001
HKU720/05
Funding Information:

The study is funded by National Natural Science Foundation of China/Research Grants Council (NSFC/RGC) (No. 30518001; HKU720/05) grant. The University of Hong Kong Foundation for Educational Development and Research, Hong Kong; the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau, Guangzhou, China, and The University of Birmingham, UK. The Guangzhou Biobank Cohort Study-CVD investigators include: the Guangzhou No. 12 Hospital: JM Lin, XJ Yue, CQ Jiang (Co-PI); The University of Hong Kong: TH Lam, BMY Cheung; The Chinese University of Hong Kong: B Tomlinson, KS Wong; The University of Birmingham: GN Thomas (Co-PI), KK Cheng.

dc.identifier.issn0021-9150
2011 Impact Factor: 3.794
2011 SCImago Journal Rankings: 0.372
dc.identifier.issue2
dc.identifier.pmid21167485
dc.identifier.scopuseid_2-s2.0-79151476007
dc.identifier.spage391
dc.identifier.urihttp://hdl.handle.net/10722/129275
dc.identifier.volume214
dc.languageeng
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
dc.publisher.placeIreland
dc.relation.ispartofAtherosclerosis
dc.relation.referencesReferences in Scopus
dc.subject.meshAge Factors
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAsian Continental Ancestry Group - genetics
dc.subject.meshCarotid Arteries - ultrasonography
dc.subject.meshCarotid Artery Diseases - ethnology - genetics - ultrasonography
dc.subject.meshChi-Square Distribution
dc.subject.meshChina
dc.subject.meshFemale
dc.subject.meshGene Frequency
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshHomozygote
dc.subject.meshHumans
dc.subject.meshIntrons
dc.subject.meshLinear Models
dc.subject.meshLinkage Disequilibrium
dc.subject.meshLogistic Models
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshOdds Ratio
dc.subject.meshPhenotype
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshRisk Assessment
dc.subject.meshRisk Factors
dc.subject.meshSex Factors
dc.subject.meshTransforming Growth Factor beta1 - genetics
dc.subject.meshTunica Intima - ultrasonography
dc.subject.meshTunica Media - ultrasonography
dc.subjectAtherosclerosis
dc.subjectCarotid plaque
dc.subjectIntima-media thickness
dc.subjectTGF-β1
dc.titleA polymorphism in transforming growth factor-β1 is associated with carotid plaques and increased carotid intima-media thickness in older Chinese men: The Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. University of Birmingham
  3. Guangzhou No. 12 Hospital
  4. Chinese University of Hong Kong