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Article: A polymorphism in transforming growth factor-β1 is associated with carotid plaques and increased carotid intima-media thickness in older Chinese men: The Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort

TitleA polymorphism in transforming growth factor-β1 is associated with carotid plaques and increased carotid intima-media thickness in older Chinese men: The Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort
Authors
KeywordsAtherosclerosis
Carotid plaque
Intima-media thickness
TGF-β1
Issue Date2011
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
Citation
Atherosclerosis, 2011, v. 214 n. 2, p. 391-396 How to Cite?
AbstractObjective: Polymorphisms of the transforming growth factor-β1 (TGFB1) gene have not been associated with asymptomatic atherosclerosis previously. We investigated the relationship between a single nucleotide polymorphism (SNP) rs4803455 in TGFB1 and atherosclerosis identified by the presence of carotid plaque and increased intima-media thickness (IMT) in an older Chinese population. Methods: 1996 subjects (992 (49.7%) men aged 50-85 years) from the Guangzhou Biobank Cohort Study-Cardiovascular Subcohort (GBCS-CVD) were genotyped. Carotid plaque and IMT were assessed by B-mode ultrasonography. Results: In male subjects, the C allele of TGFB1 rs4803455 was significantly associated with prevalence of carotid plaque (adjusted OR: 2.49, 95% CI: 1.16-5.36, P = 0.03). The C allele was related to increased number of common carotid artery (CCA) plaques (P = 0.03) and larger carotid plaque area (P = 0.02) in men. The homozygous carriers of allele C in male subjects also had a higher risk of having carotid IMT ≥1. mm (adjusted OR: 1.75, 95% CI: 1.05-2.93, P = 0.03). These associations were independent of age, smoking, physical activity, body mass index, blood pressure, lipid profile, fasting glucose and high sensitivity C-reactive protein. Conclusion: This is the first study to show that the C allele in TGFB1 was associated with increased risk of atherosclerosis in older Chinese men. Further investigations on the linkage between the TGFB1 gene and progression of atherosclerosis in asymptomatic populations are warranted. © 2010 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/129275
ISSN
2014 Impact Factor: 3.994
2014 SCImago Journal Rankings: 1.529
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China/Research Grants Council (NSFC/RGC)30518001
HKU720/05
Funding Information:

The study is funded by National Natural Science Foundation of China/Research Grants Council (NSFC/RGC) (No. 30518001; HKU720/05) grant. The University of Hong Kong Foundation for Educational Development and Research, Hong Kong; the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau, Guangzhou, China, and The University of Birmingham, UK. The Guangzhou Biobank Cohort Study-CVD investigators include: the Guangzhou No. 12 Hospital: JM Lin, XJ Yue, CQ Jiang (Co-PI); The University of Hong Kong: TH Lam, BMY Cheung; The Chinese University of Hong Kong: B Tomlinson, KS Wong; The University of Birmingham: GN Thomas (Co-PI), KK Cheng.

References

 

DC FieldValueLanguage
dc.contributor.authorDeng, HBen_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorTomlinson, Ben_HK
dc.contributor.authorLiu, Ben_HK
dc.contributor.authorLin, JMen_HK
dc.contributor.authorWong, KSen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorThomas, GNen_HK
dc.date.accessioned2010-12-23T08:34:35Z-
dc.date.available2010-12-23T08:34:35Z-
dc.date.issued2011en_HK
dc.identifier.citationAtherosclerosis, 2011, v. 214 n. 2, p. 391-396en_HK
dc.identifier.issn0021-9150en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129275-
dc.description.abstractObjective: Polymorphisms of the transforming growth factor-β1 (TGFB1) gene have not been associated with asymptomatic atherosclerosis previously. We investigated the relationship between a single nucleotide polymorphism (SNP) rs4803455 in TGFB1 and atherosclerosis identified by the presence of carotid plaque and increased intima-media thickness (IMT) in an older Chinese population. Methods: 1996 subjects (992 (49.7%) men aged 50-85 years) from the Guangzhou Biobank Cohort Study-Cardiovascular Subcohort (GBCS-CVD) were genotyped. Carotid plaque and IMT were assessed by B-mode ultrasonography. Results: In male subjects, the C allele of TGFB1 rs4803455 was significantly associated with prevalence of carotid plaque (adjusted OR: 2.49, 95% CI: 1.16-5.36, P = 0.03). The C allele was related to increased number of common carotid artery (CCA) plaques (P = 0.03) and larger carotid plaque area (P = 0.02) in men. The homozygous carriers of allele C in male subjects also had a higher risk of having carotid IMT ≥1. mm (adjusted OR: 1.75, 95% CI: 1.05-2.93, P = 0.03). These associations were independent of age, smoking, physical activity, body mass index, blood pressure, lipid profile, fasting glucose and high sensitivity C-reactive protein. Conclusion: This is the first study to show that the C allele in TGFB1 was associated with increased risk of atherosclerosis in older Chinese men. Further investigations on the linkage between the TGFB1 gene and progression of atherosclerosis in asymptomatic populations are warranted. © 2010 Elsevier Ireland Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosisen_HK
dc.relation.ispartofAtherosclerosisen_HK
dc.subjectAtherosclerosisen_HK
dc.subjectCarotid plaqueen_HK
dc.subjectIntima-media thicknessen_HK
dc.subjectTGF-β1en_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAsian Continental Ancestry Group - geneticsen_HK
dc.subject.meshCarotid Arteries - ultrasonographyen_HK
dc.subject.meshCarotid Artery Diseases - ethnology - genetics - ultrasonographyen_HK
dc.subject.meshChi-Square Distributionen_HK
dc.subject.meshChinaen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Frequencyen_HK
dc.subject.meshGenetic Predisposition to Diseaseen_HK
dc.subject.meshHomozygoteen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIntronsen_HK
dc.subject.meshLinear Modelsen_HK
dc.subject.meshLinkage Disequilibriumen_HK
dc.subject.meshLogistic Modelsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOdds Ratioen_HK
dc.subject.meshPhenotypeen_HK
dc.subject.meshPolymorphism, Single Nucleotideen_HK
dc.subject.meshRisk Assessmenten_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSex Factorsen_HK
dc.subject.meshTransforming Growth Factor beta1 - geneticsen_HK
dc.subject.meshTunica Intima - ultrasonographyen_HK
dc.subject.meshTunica Media - ultrasonographyen_HK
dc.titleA polymorphism in transforming growth factor-β1 is associated with carotid plaques and increased carotid intima-media thickness in older Chinese men: The Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohorten_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.atherosclerosis.2010.11.025en_HK
dc.identifier.pmid21167485en_HK
dc.identifier.scopuseid_2-s2.0-79151476007en_HK
dc.identifier.hkuros183452en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79151476007&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume214en_HK
dc.identifier.issue2en_HK
dc.identifier.spage391en_HK
dc.identifier.epage396en_HK
dc.identifier.isiWOS:000286651100025-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridDeng, HB=16745302600en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridTomlinson, B=16423466900en_HK
dc.identifier.scopusauthoridLiu, B=36079151900en_HK
dc.identifier.scopusauthoridLin, JM=35409737900en_HK
dc.identifier.scopusauthoridWong, KS=7404759405en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK
dc.identifier.citeulike8345904-

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