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Article: Lifetime and strength of periodic bond clusters between elastic media under inclined loading

TitleLifetime and strength of periodic bond clusters between elastic media under inclined loading
Authors
Issue Date2009
PublisherCell Press. The Journal's web site is located at http://www.cell.com/biophysj/
Citation
Biophysical Journal, 2009, v. 97 n. 9, p. 2438-2445 How to Cite?
AbstractFocal adhesions are clusters of specific receptor-ligand bonds that link an animal cell to an extracellular matrix. To understand the mechanical responses of focal adhesions, here we develop a stochastic-elasticity model of a periodic array of adhesion clusters between two dissimilar elastic media subjected to an inclined tensile stress, in which stochastic descriptions of molecular bonds and elastic descriptions of interfacial traction are unified in a single modeling framework. We first establish a fundamental scaling law of interfacial traction distribution and derive a stress concentration index that governs the transition between uniform and cracklike singular distributions of the interfacial traction within molecular bonds. Guided by this scaling law, we then perform Monte Carlo simulations to investigate the effects of cluster size, cell/extracellular matrix modulus, and loading direction on lifetime and strength of the adhesion clusters. The results show that intermediate adhesion size, stiff substrate, cytoskeleton stiffening, and low-angle pulling are factors that contribute to the stability of focal adhesions. The predictions of our model provide feasible explanations for a wide range of experimental observations and suggest possible mechanisms by which cells can modulate adhesion and deadhesion via cytoskeletal contractile machinery and sense mechanical properties of their surroundings. © 2009 by the Biophysical Society.
Persistent Identifierhttp://hdl.handle.net/10722/129271
ISSN
2015 Impact Factor: 3.632
2015 SCImago Journal Rankings: 2.188
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQian, Jen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorLin, Yen_HK
dc.contributor.authorGao, Hen_HK
dc.date.accessioned2010-12-23T08:34:27Z-
dc.date.available2010-12-23T08:34:27Z-
dc.date.issued2009en_HK
dc.identifier.citationBiophysical Journal, 2009, v. 97 n. 9, p. 2438-2445en_HK
dc.identifier.issn0006-3495en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129271-
dc.description.abstractFocal adhesions are clusters of specific receptor-ligand bonds that link an animal cell to an extracellular matrix. To understand the mechanical responses of focal adhesions, here we develop a stochastic-elasticity model of a periodic array of adhesion clusters between two dissimilar elastic media subjected to an inclined tensile stress, in which stochastic descriptions of molecular bonds and elastic descriptions of interfacial traction are unified in a single modeling framework. We first establish a fundamental scaling law of interfacial traction distribution and derive a stress concentration index that governs the transition between uniform and cracklike singular distributions of the interfacial traction within molecular bonds. Guided by this scaling law, we then perform Monte Carlo simulations to investigate the effects of cluster size, cell/extracellular matrix modulus, and loading direction on lifetime and strength of the adhesion clusters. The results show that intermediate adhesion size, stiff substrate, cytoskeleton stiffening, and low-angle pulling are factors that contribute to the stability of focal adhesions. The predictions of our model provide feasible explanations for a wide range of experimental observations and suggest possible mechanisms by which cells can modulate adhesion and deadhesion via cytoskeletal contractile machinery and sense mechanical properties of their surroundings. © 2009 by the Biophysical Society.en_HK
dc.languageengen_US
dc.publisherCell Press. The Journal's web site is located at http://www.cell.com/biophysj/ en_HK
dc.relation.ispartofBiophysical Journalen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsBiophysical Journal. Copyright © Biophysical Society.-
dc.subject.meshAnimals-
dc.subject.meshBiophysics - methods-
dc.subject.meshCell Adhesion-
dc.subject.meshComputer Simulation-
dc.subject.meshCytoskeleton - metabolism-
dc.titleLifetime and strength of periodic bond clusters between elastic media under inclined loadingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-3495&volume=97&issue=9&spage=2438&epage=2445&date=2009&atitle=Lifetime+and+strength+of+periodic+bond+clusters+between+elastic+media+under+inclined+loading-
dc.identifier.emailLin, Y:ylin@hku.hken_HK
dc.identifier.authorityLin, Y=rp00080en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.bpj.2009.08.027en_HK
dc.identifier.pmid19883586-
dc.identifier.pmcidPMC2770628-
dc.identifier.scopuseid_2-s2.0-72249098845en_HK
dc.identifier.hkuros178075en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-72249098845&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume97en_HK
dc.identifier.issue9en_HK
dc.identifier.spage2438en_HK
dc.identifier.epage2445en_HK
dc.identifier.eissn1542-0086-
dc.identifier.isiWOS:000271454000009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridQian, J=8722548700en_HK
dc.identifier.scopusauthoridWang, J=20735840000en_HK
dc.identifier.scopusauthoridLin, Y=7406585339en_HK
dc.identifier.scopusauthoridGao, H=7402971356en_HK

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